NAD+
Tested in peopleIt has been tested in people, but it is not an approved medicine. The studies are usually small.
Also called NAD / Nicotinamide Adenine Dinucleotide / NAD plus
A cell-fuel molecule, not a peptide. Sold as an IV drip or shot. Tested in people for aging and energy, with mixed results.
Can a doctor prescribe this?
No. Pharmacies are not on record as being allowed to make this into a medicine.
The FDA has not approved this as a medicine.
Not an FDA-approved drug. Sold by some clinics as an IV drip. No doctor can prescribe it as an approved medicine.
Official status: Not on the 503A bulks list. Checked 2026-08-04.
Lab suppliers we list: 16
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In human trials
See source wording
by mouth · twice a day · for 3 months
Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pressure in Patients With Moderate to Severe CKDPHASE2 · NCT04040959
“Each nicotinamide riboside capsule contains 250 mg of nicotinamide riboside chloride mixed with microcrystalline cellulose.”
500 mg
Renewal-NAD+: A Study of Oral NAD+ and Its Multi-omic Impact in a Healthy CohortEARLY_PHASE1 · NCT07336836
“NAD+ 500 mg.”
1000 mg
by mouth · once a day
The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This ResponseEARLY_PHASE1 · NCT06983730
“1000mg once a day orally for two days, once the day before the exercise session, and once the day of the exercise session..”
See source wording
Effects of NR Supplementation on Metabolic Flexibility in Zone 2 TrainingNA · NCT07344636
“600 mg NR.”
5 mg
Small Sample，Unicentric，Randomized, Controlled Clinical Study of Coenzyme I for Injection in the Treatment of Sudden Sensorineural Hearing LossEARLY_PHASE1 · NCT05849519
“Procedure:Coenzyme I for Injection,5mg，im，qd；Nacl，2ml，im，qd..”
1000 mg
by mouth
Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With SepsisPHASE4 · NCT07655791
“Nicotinamide 1000 mg.”
See source wording
by mouth · twice daily · for 40 days
NR Supplementation and ExerciseNA · NCT04907110
“The total dosage of NR per day will be 1000mg.”
See source wording
by mouth · daily · for 1 year
The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in AgingPHASE2 · NCT06208527
“A total of 2000 mg NR is administered daily for 1 year..”
400 mg
by mouth · twice daily
GKT137831 in IPF Patients With Idiopathic Pulmonary FibrosisPHASE2 · NCT03865927
“GKT137831 will be administered orally, at a dose of 400 mg twice daily, for a total of 24 weeks..”
2000 mg
by mouth · daily
Clinical Trial of Niagen to Examine Recovery in People With Persistent Cognitive and Physical Symptoms After COVID-19PHASE4 · NCT04809974
“Supplement: 60 participants will take Niagen 2000mg in the form of capsules daily.”
1000 mg
by mouth · daily
Validation of NAD+ Measurements for Human Clinical StudiesNA · NCT07416786
“All participants will receive NR 1000mg capsules to take by mouth daily for approximately 30 days.”
In animal studies
See source wording
rats ·
Assessment of methylene blue and NAD on LPS-induced acute brain injury: effects on neuroinflammation, oxidative stress, and blood-brain barrier integrity in a rat endotoxemia model.Naunyn-Schmiedeberg's archives of pharmacology · 2026
“Male Sprague-Dawley rats (n = 35) were randomized into five groups: control, LPS (8 mg/kg), LPS + NAD (250 mg/kg), LPS + MET (15 mg/kg), and LPS + NAD + MET.”
185 mg/kg
mice · by mouth · daily · for 10 days
Nicotinamide Riboside Supplementation Protects Against Heat-Induced Skeletal Muscle Injury in Female Mice.Muscles (Basel, Switzerland) · 2026
“Female 6-week-old C57BL/6J mice were orally administered vehicle or NR (185 mg/kg body weight) daily for 10 days.”
20 mg/kg
pigs · into a vein · for 1 hour
Effects and Mechanisms of NAD + on Lung Injury After Cardiac Arrest and Cardiopulmonary Resuscitation in Swine.Shock (Augusta, Ga.) · 2026
“At 5 minutes after successful resuscitation, the CPR + NAD + group received intravenous NAD + (20 mg/kg over 1 hour), while the other groups received a vehicle solution.”
- Oral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial.
Study in people
GeroScience · 2026
- Efficacy and Safety of a Topical Nicotinamide Adenine Dinucleotide Skinbooster for the Treatment of Melasma.
Study in people
Aesthetic plastic surgery · 2026
- Dysregulation of the Glycolytic Entry Gate and Survival Route by Advanced Lipoxidation End Products in Diabetes Mellitus.
Study in people
Journal of ophthalmology · 2026
- Nicotinamide Adenine Dinucleotide as a Potential Biomarker for Graft Viability During Normothermic Machine Perfusion-An Ex Vivo Rodent Study.
Animal study, rats or mice
Artificial organs · 2026
- Placental nicotinamide adenine dinucleotide modulates the timing of labor.
Animal study, rats or mice
Science (New York, N.Y.) · 2026
- Therapeutic effect of intranasal nicotinamide adenine dinucleotide in the restoration of olfactory dysfunction.
Animal study, rats or mice
Experimental & molecular medicine · 2026
- Glucocorticoid excess disrupts NAD+ homeostasis in male and female mice.
Animal study, rats or mice
The Journal of endocrinology · 2026
- Aging disrupts cumulus–oocyte NAD⁺ homeostasis
Animal study, rats or mice
Journal not recorded · 2026
- Assessment of methylene blue and NAD on LPS-induced acute brain injury: effects on neuroinflammation, oxidative stress, and blood-brain barrier integrity in a rat endotoxemia model.
Animal study, rats or mice
Naunyn-Schmiedeberg's archives of pharmacology · 2026
- Ergothioneine attenuates age-related declines in circadian rhythmicity.
Animal study, rats or mice
Biochemical and biophysical research communications · 2026
- Tracing NAD<sup>+</sup> metabolism uncovers adaptive coordination between host and microbiome during colitis.
Animal study, rats or mice
Cell reports · 2026
- Inhibition of CD38 by 78c Enhanced NAD<sup>+</sup> and Alleviated Alveolar Bone Loss in Mice with Experimental Periodontitis.
Animal study, rats or mice
International journal of molecular sciences · 2026
- Nicotinamide Riboside Supplementation Protects Against Heat-Induced Skeletal Muscle Injury in Female Mice.
Animal study, rats or mice
Muscles (Basel, Switzerland) · 2026
- Inhibition of CD38 by 78c Enhanced NAD<sup>+</sup> and Alleviated Alveolar Bone Loss in Mice with Experimental Periodontitis
Animal study, rats or mice
Journal not recorded · 2026
- AMPK senses cellular levels of nicotinamide adenine dinucleotide
Lab dish study
Journal not recorded · 2026
- Targeting the NAD<sup>+</sup> salvage pathway: Identification of bifunctional NAMPT inhibitors and SIRT1 activators through pharmacophore-based virtual screening.
Lab dish study
Bioorganic & medicinal chemistry · 2026
- Restoration of Redox Homeostasis and Endogenous Aldehyde Detoxification by UT-018 Following Acute Ethanol Exposure
Lab dish study
Journal not recorded · 2026
- Multi-module immobilization of Gluconobacter frateurii alcohol dehydrogenase and Lactobacillus brevis NADH oxidase with tethered nicotinamide adenine dinucleotide for D-allulose biosynthesis.
International journal of biological macromolecules · 2026
- Synthesis, Characterization, and Fluorescence Application of Indole-Based Isofunctional NAD<sup>+</sup> Analogs.
Chembiochem : a European journal of chemical biology · 2026
- The Role of Oxidative Stress in Heart Failure: Mechanisms and Therapeutic Targets.
Cureus · 2026
- Autophagy-Related Gene-Set Signals in the Genetic Architecture of Obsessive-Compulsive Disorder: A Hypothesis-Generating Link to Nicotinamide Adenine Dinucleotide-Associated Cellular Maintenance Biology.
Cureus · 2026
- Spatiotemporal biosensor profiling reveals an autonomous mitochondrial NAD <sup>+</sup> /NMN regulatory network centered on NMNAT3
Journal not recorded · 2026
- Laser-Engineered Ag Nanoparticle on Carbon Cloth Electrodes for Enzyme-Free Electrochemical NAD<sup>+</sup> Detection.
Small (Weinheim an der Bergstrasse, Germany) · 2026
- High-titer nicotinamide adenine dinucleotide production via artificially designed pseudo-de novo biosynthesis pathway.
Bioresource technology · 2026
- Starving leukemia: nicotinamide phosphoribosyltransferase-dependent nicotinamide adenine dinucleotide salvage links metabolic vulnerability to therapeutic sensitivity in acute myeloid leukemia.
Translational cancer research · 2026
- Nicotinamide adenine dinucleotide inhibits the production of reactive oxygen species and myocardial cell pyroptosis caused by hypoxia/re-oxygenation injury.
World journal of cardiology · 2026
- Effects and Mechanisms of NAD + on Lung Injury After Cardiac Arrest and Cardiopulmonary Resuscitation in Swine.
Shock (Augusta, Ga.) · 2026
- NAD+ depletion links metabolic stress to drive innate immune priming and selectively control PANoptosis.
Journal of immunology (Baltimore, Md. : 1950) · 2026
- Dual Single-Atom Engineered NADH Oxidase-Mimic Boosts In Situ NAD<sup>+</sup> Biotransformation for Targeted Myocardial Ischemia/Reperfusion Protection.
Advanced materials (Deerfield Beach, Fla.) · 2026
- NAD+ metabolic collapse and arrest of epithelial development in Hirschsprung disease.
World journal of pediatric surgery · 2026
- The <i>E. coli</i> DEAD box ATPase CsdA, is a NAD <sup>+</sup> capped RNA binding protein
Journal not recorded · 2026
- NAD<sup>+</sup> modulates REST isoform expression and its downstream mitophagy in Alzheimer's disease.
Autophagy · 2026
- Rickettsia parkeri subverts nicotinamide adenine dinucleotide (NAD+) metabolic pathway for its survival in endothelial cells.
The FEBS journal · 2026
- Niacin Alleviates Browning in Fresh-Cut Potatoes: Regulation of NADPH/NADH Levels Mediates ROS-Redox Homeostasis and the Ascorbate-Glutathione Cycle.
Foods (Basel, Switzerland) · 2026
- Metabolic Brain Disorders: Prodromes, Symptoms, and Syndromes.
International journal of molecular sciences · 2026
- Application of Organic Small-Molecule Fluorescent Probes for NAD(P)H Imaging and Detection.
Review of earlier work
Chemistry, an Asian journal · 2026
- Role of nicotinamide adenine dinucleotide in cardiovascular disease.
Review of earlier work
Current opinion in cardiology · 2026
- The role of redox state in regulating plant secondary metabolism under stress.
Review of earlier work
Functional plant biology : FPB · 2026
- Intracrine androgen metabolism in the meibomian gland: regulation, circadian control, and implications in dry eye disease.
Review of earlier work
Endocrine journal · 2026
- Virtual Nature, Metaverse, and NAD⁺: A Narrative Review for Health Planning and Healthy Ageing.
Review of earlier work
Health science reports · 2026
- NAD Metabolism in Acute Myeloid Leukaemia: Biological Rationale and Therapeutic Opportunities.
Review of earlier work
Nutrients · 2026
- Micronutrition as a Therapeutic Strategy to Restore Mitochondrial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia
Review of earlier work
Journal not recorded · 2026
- Sirtuins at the Interface of Glucose Metabolism, Diabetes, and Heart Failure: Metabolic Sensing in Cardiometabolic Disease.
Review of earlier work
International journal of molecular sciences · 2026
- Opposing Molecular Programs in Obsessive-Compulsive Disorder and Hoarding: Transcriptome-Wide Association Studies Reveal Distinct Senescence, Complement, and Metabolic Signatures.
Review of earlier work
Cureus · 2026
- Targeting Sirtuin Signaling in Parkinson's Disease and Neurodegeneration: Molecular Insights and Translational Potential.
Review of earlier work
Molecular neurobiology · 2026
- SLC25A51 and mitochondrial NAD⁺ transport in acute myeloid leukemia: mechanisms, therapeutic potential, and translational perspectives.
Review of earlier work
Human cell · 2026
- Symptom-Level Precision Neurology in Amyotrophic Lateral Sclerosis (ALS): Linking Microglial Pruning, Mitochondrial Nicotinamide Adenine Dinucleotide (NAD+) Compensation, and Autophagy Failure Across the Aging Spectrum.
Review of earlier work
Cureus · 2026
- Metabolic Flux Adaptations During GLP-1 Receptor Agonist Therapy: Redox Implications.
Review of earlier work
Current obesity reports · 2026