TB-500
Animal studies onlyAlmost all the research is in animals. We do not know if the same thing happens in people.
Also called Thymosin Beta-4 fragment / TB4 frag 17-23
A fragment of a natural protein studied for wound repair and cell movement, mostly in animals. There is no approved human use.
The basics
- What is it?
- A short piece of a natural body protein called thymosin beta-4, which helps cells move around.
- What do we know?
- In animals, it seems to help cells move into damaged areas, which is part of how wounds close.
- What do we still not know?
- Whether any of that happens in people. Human studies are missing.
Can a doctor prescribe this?
No. It sits on a restricted list, so pharmacies are not allowed to make it.
The FDA has not approved this as a medicine.
Not FDA approved and placed in the restricted category for 503A compounding.
Official status: Category 2 – restricted from compounding. Checked 2026-06-30.
Lab suppliers we list: 16
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In animal studies
These are doses given to animals, usually per kilogram of body weight. They do not convert directly to a human dose.
See source wording
rats · another route
Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.Joint diseases and related surgery · 2026
“Materials and methods Thirty-two male Sprague-Dawley rats, each aged 12 weeks and weighing approximately 330 g, underwent standardized Achilles tendon transection and repair and were randomly assigned to four groups, with eight rats in each group: control, BPC-157 (10 µg/kg/day), TB-500 (60 µg/kg/day), and combined BPC-157 + TB-500 (BPC + TB).”
- Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.
Animal study, rats or mice
Joint diseases and related surgery · 2026
- Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro.
Animal study, rats or mice
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2024
- Adsorption effects of the doping relevant peptides Insulin Lispro, Synachten, TB-500 and GHRP 5.
Analytical biochemistry · 2017
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
Review of earlier work
Journal not recorded · 2026
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Review of earlier work
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
- Thymosin Beta-4 and TB-500 in Tissue Healing, Regeneration, and Musculoskeletal Repair: A Scoping Review
Review of earlier work
Journal not recorded · 2026
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Review of earlier work
Sports medicine (Auckland, N.Z.) · 2026
- Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.
Review of earlier work
Frontiers in aging · 2026
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
Review of earlier work
Journal not recorded · 2025