Sermorelin
Approved, discontinuedGet notified when the evidence changes.
The FDA approved a version of this in the past, but that product is no longer sold. It went through large studies in people.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2024-09-27
Also called GRF 1-29 / Geref / Sermorelin acetate
A shortened copy of a natural hormone that tells the body to make growth hormone. Doctors can prescribe it.
Official status: Pharmacies may compound it · Checked 2024-09-27
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Category 1 — under review, allowed for now
Was FDA-approved as Geref; the brand was discontinued. Pharmacies can still compound it with a prescription.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 13
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
No dosing information has been published in the research indexed here.
- Study in peopleOutcome of growth hormone therapy in children with growth hormone deficiency showing an inadequate response to growth hormone-releasing hormone.
Endocrine · 2001
- Study in peopleOnce daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group.
The Journal of clinical endocrinology and metabolism · 1996
- Data from people, not a trialAnterior cervical osteophyte-related dysphagia in a long-term growth hormone user: a case report.
Frontiers in surgery · 2026
- Animal study, larger animalsEffect of galanin on the growth hormone (GH) response to GH-releasing hormone in patients with Cushing's disease.
Endocrine research · 1993
- Lab dish studyAdvances in the detection of growth hormone releasing hormone synthetic analogs.
Drug testing and analysis · 2021
- Lab test method, not a health studyAnalysis of growth hormone releasing hormone and its analogs in urine using nano liquid chromatography coupled with quadrupole/orbitrap mass spectrometry.
Journal of pharmaceutical and biomedical analysis · 2026
- Testing of products for sale, not a health studyEvaluation of Research Grade Peptides Marketed Directly to Consumers Reveals Extensive Variability in Purity and Measured Abundance
2026
- Lab test method, not a health studyA new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review.
The Journal of sports medicine and physical fitness · 2026
- Lab test method, not a health studyChromatographic-mass spectrometric analysis of peptidic analytes (2-10 kDa) in doping control urine samples.
Journal of mass spectrometry : JMS · 2024
- Lab test method, not a health studyCationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples.
Analytical biochemistry · 2023
- Lab test method, not a health studyOnline large volume sample staking preconcentration and separation of enantiomeric GHRH analogs by capillary electrophoresis.
Electrophoresis · 2023
- Lab test method, not a health studyIn-house standards derived from doping peptides: Enzymatic and serum stability and degradation profile of GHRP and GHRH-related peptides.
Biomedical chromatography : BMC · 2023
- Lab test method, not a health studyAn antibody-free, ultrafiltration-based assay for the detection of growth hormone-releasing hormones in urine at low pg/mL concentrations using nanoLC-HRMS/MS.
Journal of pharmaceutical and biomedical analysis · 2022
- Lab test method, not a health studyProbing for peptidic drugs (2-10 kDa) in doping control blood samples.
Analytical science advances · 2022
- Lab test method, not a health studyComparison of magnetic bead surface functionalities for the immunopurification of growth hormone-releasing hormones prior to liquid chromatography-high resolution mass spectrometry.
Journal of chromatography. A · 2020
- Lab test method, not a health studyGlycine-modified growth hormone secretagogues identified in seized doping material.
Drug testing and analysis · 2019
- Lab test method, not a health studyQualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS.
Analytical and bioanalytical chemistry · 2016
- A potentially effective drug for patients with recurrent glioma: sermorelin.
Annals of translational medicine · 2021
- The negative GH auto-feedback in childhood: effects of rhGH and/or GHRH on the somatotroph response to GHRH or hexarelin, a peptidyl GH secretagogue, in children.
Journal of endocrinological investigation · 2000
- Clonidine pretreatment modifies the growth hormone secretory pattern induced by short-term continuous GRF infusion in normal man.
Clinical endocrinology · 1991
- Lack of effect of muscarinic cholinergic blockade on the GH responses to GRF 1-29 and TRH in acromegalic subjects.
Clinical endocrinology · 1986
- Influence of dopaminergic, adrenergic and cholinergic blockade and TRH administration on GH responses to GRF 1-29.
Clinical endocrinology · 1986
- Stimulation of growth hormone secretion with human growth hormone releasing factors (GRF1-44, GRF1-40, GRF1-29) in normal subjects.
Klinische Wochenschrift · 1984
- Review of earlier workThe emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
Frontiers in endocrinology · 2026
- Review of earlier workSafety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Sports medicine (Auckland, N.Z.) · 2026
- Review of earlier workTherapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
- Review of earlier workBeyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.
Translational andrology and urology · 2020
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What has happened so far
- 21 March 2025503B
FDA lists "Sermorelin Acetate" — the acetate salt, the form pharmacies handle — under 503B Category 1: Bulk Drug Substances Under Evaluation. Category 1 means FDA does not intend to act against an outsourcing facility compounding it while the evaluation continues; it is not the final 503B Bulks List. Read from the FDA 503B category document dated March 21, 2025.