Semax
Tested in peopleIt has been tested in people, but it is not an approved medicine. The studies are usually small.
Also called ACTH 4-10 analogue / Met-Glu-His-Phe-Pro-Gly-Pro / N-Acetyl Semax
Developed in Russia and used there for stroke recovery. Little research exists outside Russia.
Can a doctor prescribe this?
Not yet. An FDA advisory panel said it should be allowed, but the rule is not final, so pharmacies still cannot make it.
The FDA has not approved this as a medicine.
An FDA advisory panel voted 8-5 in favor in July 2026, but the rule isn't final. That usually takes a year or more.
Official status: Recommended, pending FDA rulemaking. Checked 2026-07-24.
Lab suppliers we list: 16
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In animal studies
These are doses given to animals, usually per kilogram of body weight. They do not convert directly to a human dose.
60 nmol/kg
rats · another route · daily
Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.European journal of pharmacology · 2024
“Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII.”
100 mcg/kg
rats ·
Antistress Action of Melanocortin Derivatives Associated with Correction of Gene Expression Patterns in the Hippocampus of Male Rats Following Acute Stress.International journal of molecular sciences · 2021
“Administration of Semax or ACTH(6-9)PGP (100 μg/kg) to rats 30 min before ARS attenuated ARS-induced behavioral alterations.”
- The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons.
Animal study, rats or mice
Bulletin of experimental biology and medicine · 2025
- Effect of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury models (male Sprague Dawley rats)
Animal study, rats or mice
Journal not recorded · 2025
- The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease.
Animal study, rats or mice
Acta naturae · 2025
- Genes That Associated with Action of ACTH-like Peptides with Neuroprotective Potential in Rat Brain Regions with Different Degrees of Ischemic Damage.
Animal study, rats or mice
International journal of molecular sciences · 2025
- ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke.
Animal study, rats or mice
Biomedicines · 2024
- Changes of Transcriptomic Activity in Rat Brain Cells under the Influence of Synthetic Adrenocorticotropic Hormone-Like Peptides.
Animal study, rats or mice
Biochemistry. Biokhimiia · 2024
- Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.
Animal study, rats or mice
European journal of pharmacology · 2024
- Synthetic Adrenocorticotropic Peptides Modulate the Expression Pattern of Immune Genes in Rat Brain following the Early Post-Stroke Period.
Animal study, rats or mice
Genes · 2023
- Insight into Glyproline Peptides' Activity through the Modulation of the Inflammatory and Neurosignaling Genetic Response Following Cerebral Ischemia-Reperfusion.
Animal study, rats or mice
Genes · 2022
- A Mouse Model of Nigrostriatal Dopaminergic Axonal Degeneration As a Tool for Testing Neuroprotectors.
Animal study, rats or mice
Acta naturae · 2021
- Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.
Animal study, rats or mice
Neuropeptides · 2021
- Antistress Action of Melanocortin Derivatives Associated with Correction of Gene Expression Patterns in the Hippocampus of Male Rats Following Acute Stress.
Animal study, rats or mice
International journal of molecular sciences · 2021
- Brain Protein Expression Profile Confirms the Protective Effect of the ACTH<sub>(4-7)</sub>PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion.
Animal study, rats or mice
International journal of molecular sciences · 2021
- Novel Insights into the Protective Properties of ACTH<sub>(4-7)</sub>PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats.
Animal study, rats or mice
Genes · 2020
- The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.
Animal study, rats or mice
BMC genomics · 2014
- [Proteolysis of simple glyprolines by leucine aminopeptidase and enzymes from nasal slime, brain membranes, and rat blood].
Animal study, rats or mice
Bioorganicheskaia khimiia · 2013
- Effect of semax and its C-terminal fragment Pro-Gly-Pro on the expression of VEGF family genes and their receptors in experimental focal ischemia of the rat brain.
Animal study, rats or mice
Journal of molecular neuroscience : MN · 2013
- The effect of Semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study.
Animal study, rats or mice
Journal of molecular neuroscience : MN · 2011
- Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.
Animal study, rats or mice
Neurochemical research · 2005
- Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing.
Lab dish study
Bioinorganic chemistry and applications · 2025
- Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties.
Lab dish study
Journal of inorganic biochemistry · 2016
- Effects of behaviorally active ACTH (4-10) analogue - Semax on rat basal forebrain cholinergic neurons.
Lab dish study
Restorative neurology and neuroscience · 2008
- Digitally Guided Hybrid Maxillary Expansion with Supragingival Mandibular Miniplates for Class III Correction in Late Adolescents: A Pilot Clinical Study.
Journal of clinical medicine · 2026
- [Effect of a combined physiotherapeutic approach on changes in functional parameters after endovitreal surgery of rhegmatogenous retinal detachment with a favorable anatomical outcome].
Vestnik oftalmologii · 2026
- Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models.
ACS chemical neuroscience · 2022
- Investigation of the effect of a modified fragment of neuropeptide Y on memory phases and extrapolation escape of animals.
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti · 2021
- Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of "Social" Stress.
Bulletin of experimental biology and medicine · 2019
- Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology.
Beilstein journal of nanotechnology · 2017
- [Proteolysis of semax analogues with different N-terminal amino acids by aminopeptidases].
Bioorganicheskaia khimiia · 2011
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Review of earlier work
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
- Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.
Review of earlier work
Frontiers in aging · 2026
- Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.
Review of earlier work
British journal of pharmacology · 2025
- Modulation of neuropathological pathways by bioactive peptides and proteins/polypeptides: Targeting oxidative stress in neurodegenerative diseases.
Review of earlier work
Neuropeptides · 2025