Selank

In animal studies

These are doses given to animals, usually per kilogram of body weight. They do not convert directly to a human dose.

• See source wording

  rats · another route

  Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.Bulletin of experimental biology and medicine · 2022

  “Single intraperitoneal injection of Selank in an anxiolytic dose of 0.3 mg/kg reduced the total index of morphine withdrawal syndrome by 39.6%, significantly (р<0.0001) attenuated convulsive reactions, ptosis, and posture disorders, and 9-fold increased the tactile sensitivity threshold in morphine-dependent rats in comparison with the group of active control; at the same time, Selank was slightly inferior to diazepam in a dose of 2 mg/kg by pharmacological activity (the decrease in total index of morphine withdrawal syndrome by 49.3% and 13-fold increase in sensitivity threshold).”

• 100 mcg/kg/day

  rats · another route · for 20 days

  The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.Current reviews in clinical and experimental pharmacology · 2021

  “Laboratory animals were divided into 3 groups: a group of intact males, a group of animals that were subjected to stress (sensory contact) for 20 days and a group that received intraperitoneally Selank at a dose of 100 mcg/kg/day under conditions of 20-day stress.”

• 750 mcg/kg

  rats · another route

  Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank.Bulletin of experimental biology and medicine · 2020

  “Selank was injected intraperitoneally in doses of 80, 250, and 750 μg/kg 15 min before stress exposure.”

• See source wording

  rats · another route

  Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.Bulletin of experimental biology and medicine · 2019

  “Selank was injected intraperitoneally in doses of 100, 300 and 1000 μg/kg 15 min before each stress session.”

• 750 mcg/kg

  rats · another route

  State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment.Bulletin of experimental biology and medicine · 2019

  “Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure.”

• See source wording

  rats · another route

  Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.Bulletin of experimental biology and medicine · 2017

  “We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.”

• 100 ng

  mice ·

  Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells.Bulletin of experimental biology and medicine · 2017

  “Analysis of differentiation of embryonic stem cells into GABA + neurons showed that Selank, thyroliberin (100 μM), and NGF (100 ng/ml) decrease the ratio of these cells by 61, 58, and 87%, respectively, in comparison with the control.”

• See source wording

  mice · another route · single dose

  Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice.Bulletin of experimental biology and medicine · 2016

  “Selank that enhances activity of the endogenous opioid system (0.3 mg/kg, intraperitoneally), similar to the nonselective opiate receptor blocker naloxone (1.0 mg/kg, intraperitoneally), prevented the development of ethanol-induced (2.0 g/kg intraperitoneally) hyperlocomotion, in contrast to σ1-receptors agonist Afobazole (1.0 mg/kg, intraperitoneally) that did not inhibit ethanol-induced behavioral stimulation.”

• 300 mcg/kg/day

  mice · nasal spray · for 5 days

  [COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.]Eksperimental'naia i klinicheskaia farmakologiia · 2016

  “Pharmacological effects of intraperitoneal (i.p.) and intranasal (i.n.) administration of heptapeptide selank (300 μg/kg/day for 5 days), known to possess anxiolytic and nootropic properties, were compared by studying the elevated-plus-maze behavior of inbred BALB/c and C57BL/6 mice and measuring the binding of markers to NMDA and GABA receptors of brain.”

• 300 mcg/kg

  rats ·

  Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.Frontiers in pharmacology · 2016

  “We analyzed the expression of 84 genes involved in neurotransmission (e.g., major subunit of the GABA receptor, transporters, ion channels, dopamine, and serotonin receptors) in the frontal cortex of rats 1 and 3 h after the administration of Selank or GABA (300 μg/kg) using real-time PCR method.”

• 100 mcg/kg

  mice · another route

  The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action.Molecular immunology · 2014

  “In this work we studied the effect of Selank and its short fragment Gly-Pro on the temporary dynamics of C3, Casp1, Il2rg, and Xcr1 genes expression in mouse spleen after single intraperitoneal injection (100 μg/kg) of peptides using real-time PCR method.”

• See source wording

  rats · another route · daily · for 24 weeks

  Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation.Bulletin of experimental biology and medicine · 2014

  “In alcohol-preferring animals (mean daily ethanol intake >5.0 g/kg) allowed free choice between 10 % ethanol and water, single intraperitoneal injection of selank in a dose of 0.3 mg/kg eliminated anxiety induced by ethanol withdrawal in tests elevated plus maze and social interaction tests and prevented the formation of mechanical allodynia without affecting ethanol consumption.”

• See source wording

  rats ·

  [Protective effect of selank on the model of mnestic function violation induced by pharmacological blockade of protein synthesis].Eksperimental'naia i klinicheskaia farmakologiia · 2013

  “Selank (0.5 mg/kg, i.p.) prevented or compensated for actinomycin D (250 mg/kg, i.p.) induced violation of the process of acquisition, improvement, and consolidation of memory trace during the development of a complex site reflex.”

• See source wording

  mice ·

  [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank].Eksperimental'naia i klinicheskaia farmakologiia · 2012

  “Selank (0.25 mg/kg, i.p.) per se exhibited anxiolytic effect in BALB/C mice by increasing the general locomotor activity, with no effects on the behavior of C57BL/6 mice in the OF test.”

• 100 mcg/kg

  rats · another route

  Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank.Regulatory peptides · 2011

  “We analyzed the expression of 84 genes involved in processes of inflammation (e.g., chemokines, cytokines, and its receptors) in mouse spleen 6 and 24 h after Selank single intraperitoneal injection (100 μg/kg) using real-time PCR method.”

• 0.3 mg/kg

  rats · another route · for 30 weeks

  Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.Bulletin of experimental biology and medicine · 2019

  “In the object recognition test, Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol (p<0.05) and prevented the formation of ethanol-induced memory and attention disturbances (p<0.01) developing during alcohol withdrawal.”