Retatrutide
Tested in peopleGet notified when the evidence changes.
It has been tested in people, but it is not an approved medicine. The studies are usually small.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-08-04
Also called LY3437943 / Triple G / GGG tri-agonist
Hits three different hormone targets at once for weight loss. In late-stage human trials, not yet approved.
Watch: what the research shows
Retatrutide: What The Research Actually Shows
Real trials in the best medical journals. Zero approvals anywhere. Everyone taking it is buying grey market.
Official status: Not nominated for 503A compounding · Checked 2026-08-04
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Still an investigational drug in clinical trials. Not approved and not legal to compound.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 4
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Study in peopleEfficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial.
Lancet (London, England) · 2026
- Study in peopleRationale, design and baseline characteristics of the TRANSCEND-CKD trial of retatrutide in patients with chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
- Study in peopleRetatrutide And Lipid And Metabolite Profiles In Participants With Obesity With Or Without Type 2 Diabetes.
The Journal of clinical endocrinology and metabolism · 2026
- Study in peopleRetatrutide-Associated Improvements in Cardiovascular Risk Biomarkers in Adults With Obesity With or Without Type 2 Diabetes.
Diabetes, obesity & metabolism · 2026
- Study in peopleEffects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial.
The lancet. Diabetes & endocrinology · 2025
- Study in peoplePerceived benefits of treatment for obesity with retatrutide: A qualitative study of patients in a phase 2 clinical trial.
Obesity pillars · 2025
- Study in peopleAppetite, eating attitudes, and eating behaviours during treatment with retatrutide in adults with type 2 diabetes: Results of a phase 2 study.
Diabetes, obesity & metabolism · 2025
- Study in peopleTriple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial.
Nature medicine · 2024
- Study in peopleTriple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial.
The New England journal of medicine · 2023
- Study in peopleRetatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA.
Lancet (London, England) · 2023
- Study in peopleLY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial.
Lancet (London, England) · 2022
- Data from people, not a trialSelf-Reported Side Effects Among Reddit Users Taking Nonapproved Retatrutide
2026
- Data from people, not a trialAccelerating Use of Unapproved Retatrutide Is Associated with Weaker Weight Loss and Increased Cardiovascular Symptoms
2026
- Data from people, not a trialIncretin-based therapies for the treatment of obesity-related diseases.
npj metabolic health and disease · 2024
- Animal study, rats or miceCagrilintide and retatrutide combination therapy enhances weight loss and metabolic outcomes in obese male rats.
Nature metabolism · 2026
- Animal study, rats or miceEffects of retatrutide on learning and memory in streptozotocin-induced male diabetic rats.
Behavioural brain research · 2026
- Animal study, rats or miceRetatrutide Treatment in Streptozotocin-Induced Diabetic Rats: Renal Inflammatory Cytokines, HIF‑1α Signalling, and Histopathological Injury Profile
2026
- Animal study, rats or miceRetatrutide effects on diabetic rats' cognition.
Lab animal · 2026
- Animal study, rats or miceMulti-omic profiling reveals Retatrutide alleviates adipose tissue fibrosis via metabolic reprogramming and tissue repair.
Diabetology & metabolic syndrome · 2026
- Animal study, rats or miceRetatrutide Shows Multiple Metabolic Benefits in Diet-Induced Obese MASH Mouse and Hamster Models.
Obesity (Silver Spring, Md.) · 2026
- Animal study, rats or miceGIPR:GCGR co-agonism restores normal weight in obese rodents.
Molecular metabolism · 2026
- Animal study, rats or miceEfficacy of GLP-1 analog peptides, semaglutide, tirzepatide, and retatrutide on MC4R deficient obesity and their comparison.
International journal of obesity (2005) · 2026
- Animal study, rats or miceComparative effects of semaglutide tirzepatide and retatrutide on renal fibrosis in UUO and aged mice.
iScience · 2026
- Animal study, rats or miceKynurenic acid mediates epicardial fat-induced lymphatic metabolic dysfunction in atrial fibrillation.
Nature communications · 2026
- Animal study, rats or miceIncretin triple agonist retatrutide (LY3437943) alleviates obesity-associated cancer progression.
npj metabolic health and disease · 2025
- Animal study, rats or miceRetatrutide improves steatohepatitis in an accelerated mouse model of diet-induced steatohepatitis with a fructose binge.
American journal of physiology. Gastrointestinal and liver physiology · 2025
- Human tissue in a dish, not peopleInotropic effects of retatrutide in isolated human atrial preparations.
Naunyn-Schmiedeberg's archives of pharmacology · 2026
- Lab dish studyDecreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids.
Diabetes, obesity & metabolism · 2025
- Lab test method, not a health studyDetection and Excretion Profile of Retatrutide in Human Plasma and Urine by LC-HRMS: Implications for Antidoping Analysis.
Rapid communications in mass spectrometry : RCM · 2026
- Testing of products for sale, not a health studyComposition and Labelling Accuracy of Products Sold as Retatrutide in Australia.
Drug and alcohol review · 2026
- Chemistry or materials paper, not a health studyA Hydrophobic Tag-Assisted Liquid-Phase Strategy for the Synthesis of Retatrutide.
Organic letters · 2026
- No abstract available, not yet classifiedRetatrutide fact check: Has a man died after taking the unapproved weight loss jab?
BMJ (Clinical research ed.) · 2026
- No abstract available, not yet classifiedRetatrutide and the urinary tract infection signal: Is the answer hidden in timing?
European journal of internal medicine · 2026
- Triple Hormone Receptor Agonism: The Role of Retatrutide in Addressing Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Comprehensive Review.
Cardiology in review · 2026
- No abstract available, not yet classifiedRetatrutide: Obesity drug opens to "compassionate use" in US after speculation Trump took it.
BMJ (Clinical research ed.) · 2026
- Pharmacological management of obesity: Current landscape and emerging therapies.
Indian journal of pharmacology · 2026
- The role of GLP-1 and GIP receptor agonists in the treatment of diabetes and obesity.
Pharmacological research · 2026
- Online-Sourced Retatrutide Complicating Impending Diabetic Ketoacidosis in a Patient With Type 1 Diabetes and Concurrent Shigella Gastroenteritis.
Cureus · 2026
- No abstract available, not yet classifiedRetatrutide: Triple acting jab for type 2 diabetes lowers blood sugar and boosts weight loss, trial reports.
BMJ (Clinical research ed.) · 2026
- Sustained weight loss exceeding 100 kg with sequential incretin-based therapy in Prader-Willi syndrome.
JCEM case reports · 2026
- No abstract available, not yet classifiedStructural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide.
Cell discovery · 2024
- No abstract available, not yet classifiedRetatrutide.
Clinical diabetes : a publication of the American Diabetes Association · 2024
- Unleashing the power of retatrutide: A possible triumph over obesity and overweight: A correspondence.
Health science reports · 2024
- Review of earlier workRetatrutide in type 2 diabetes mellitus and obesity: an overview.
Expert review of clinical pharmacology · 2026
- Review of earlier workThe Triple-Agonist Revolution: Retatrutide and the Paradigm Shift in Multi-Hormonal Pharmacotherapy for Obesity and Cardiometabolic Comorbidities.
Clinical pharmacology in drug development · 2026
- Review of earlier workEffect of Retatrutide, a Novel Triple Receptor Agonist, on Blood Pressure and Lipid Levels: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
- Review of earlier workComparative Efficacy and Safety of Glucagon Receptor Agonists on Metabolic Outcomes: A Network Meta-Analysis of Randomised Controlled Trials.
Endocrinology, diabetes & metabolism · 2026
- Review of earlier workDo GLP-1 Receptor Agonists Sabotage Fat Grafts? : A Scoping Review of GLP-1 Receptor Agonist Effects on Adipocyte Biology and Implications for Autologous Fat Transfer.
Aesthetic surgery journal · 2026
- Review of earlier workGLP-1 Agonists in Adolescent Obesity: A Narrative Review of Single, Dual, and Triple Agonists.
Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
- Review of earlier workEvolution of incretin-based therapies: From GLP-1 monotherapy to dual and triple agonists: A new era in metabolic therapy.
The Indian journal of medical research · 2026
- Review of earlier workEfficacy and Safety of Dual and Triple Glucagon-Like Peptide-1-Based Polyagonists in Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis: A Systematic Review and Meta-Analysis.
Cureus · 2026
- Review of earlier workEngineered nutrient-stimulated hormonal multi-agonists for precision targeting of obesity and metabolic disorders.
Clinical and molecular hepatology · 2026
- Review of earlier workComparative efficacy and safety of glucagon-like peptide 1 based drugs for weight loss in adults with overweight or obesity without diabetes: network meta-analysis of randomised controlled trials.
BMJ medicine · 2026
- Review of earlier workDangers of Injectable Peptides and Other Unregulated "Biohacking" Drugs.
Missouri medicine · 2026
- Review of earlier workEfficacy and Safety of Retatrutide in the Treatment of Diabetes and/or Obesity Comorbid with Chronic Kidney disease: a Systematic Review and Meta-Analysis.
Maedica · 2025
- Review of earlier workEfficacy and safety of triple hormone receptor agonist retatrutide for the management of obesity: a systematic review and meta-analysis.
Expert review of clinical pharmacology · 2025
- Review of earlier workTriple Agonism Based Therapies for Obesity.
Current cardiovascular risk reports · 2025
- Review of earlier workEfficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials.
Proceedings (Baylor University. Medical Center) · 2025
- Review of earlier workThe "Weight" for a New Agent Is Almost Over: A Commentary on the Novel Triagonist Retatrutide for Obesity.
The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2024
- Review of earlier workApproved and Emerging Hormone-Based Anti-Obesity Medications: A Review Article.
Indian journal of endocrinology and metabolism · 2024
- Review of earlier workIs retatrutide (LY3437943), a GLP-1, GIP, and glucagon receptor agonist a step forward in the treatment of diabetes and obesity?
Expert opinion on investigational drugs · 2023
- Review of earlier workRetatrutide showing promise in obesity (and type 2 diabetes).
Expert opinion on investigational drugs · 2023
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