PT-141
Approved medicineThe FDA has approved a version of this as a medicine, so it has been through large studies in people.
Also called Bremelanotide / Vyleesi / Melanocortin agonist
A medicine acting on brain signals linked to sexual desire, approved for low desire in premenopausal women.
The basics
- What is it?
- An approved medicine that acts on brain signals tied to sexual desire.
- What do we know?
- In studies in women with low sexual desire, some reported improvement. It is approved for that use.
- What do we still not know?
- How large the benefit really is day to day, and how well it works for anyone else.
Can a doctor prescribe this?
Yes. Pharmacies are allowed to make it, so a doctor can write a prescription for it.
The FDA has approved a version of this as a medicine.
FDA approved as bremelanotide for hypoactive sexual desire disorder in premenopausal women.
Official status: On the 503A bulks list. Checked 2026-06-05.
Lab suppliers we list: 14
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
No dosing information has been published in the research indexed here.
- An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist.
Study in people
The journal of sexual medicine · 2006
- The Synthetic Melanocortin Agonist NDP-MSH Ameliorates THSD7A-Associated Membranous Nephropathy in an Active Immunization Mouse Model.
Animal study, rats or mice
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
- PT-141: a melanocortin agonist for the treatment of sexual dysfunction.
Animal study, rats or mice
Annals of the New York Academy of Sciences · 2003
- Evaluation of Research Grade Peptides Marketed Directly to Consumers Reveals Extensive Variability in Purity and Measured Abundance
Journal not recorded · 2026
- PT-141 Palatin.
Current opinion in investigational drugs (London, England : 2000) · 2004