PEG-MGF
Animal studies onlyGet notified when the evidence changes.
Almost all the research is in animals. We do not know if the same thing happens in people.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-04-15
Also called Pegylated Mechano Growth Factor / IGF-1Ec
A variant of a growth factor that muscle releases after damage. Only animal data exists.
Official status: 503A Category 2 – significant safety risk · Checked 2026-04-15
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Still restricted. The FDA has said it plans to review this one by February 2027.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 8
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
No dosing information has been published in the research indexed here.
- Study in peoplePharmacological hypogonadism impairs molecular transducers of exercise-induced muscle growth in humans.
Journal of cachexia, sarcopenia and muscle · 2022
- Study in peopleEffect of growth hormone on aging connective tissue in muscle and tendon: gene expression, morphology, and function following immobilization and rehabilitation.
Journal of applied physiology (Bethesda, Md. : 1985) · 2014
- Data from people, not a trialImmunohistochemical expression of insulin-like growth factor-1Ec in primary endometrial carcinoma: Association with PTEN, p53 and survivin expression.
Oncology letters · 2020
- Animal study, rats or miceIntrinsic exercise capacity is associated with skeletal muscle clock gene and IGF-1 signaling in aged low- and high-running capacity rats.
Frontiers in physiology · 2026
- Animal study, rats or miceIdentification of the IGF-1 processing product human Ec/rodent Eb peptide in various tissues: Evidence for its differential regulation after exercise-induced muscle damage in humans.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2017
- Animal study, rats or miceThe human Ec peptide: the active core of a progression growth factor with species-specific mode of action.
Hormones (Athens, Greece) · 2016
- Lab dish studyAnti-PEc: Development of a novel monoclonal antibody against prostate cancer.
British journal of cancer · 2024
- Lab dish studyExpression of mechano-growth factor (MGF) in refractory overactive bladder
2023
- Lab dish studyMIR retroposon exonization promotes evolutionary variability and generates species-specific expression of IGF-1 splice variants.
Biochimica et biophysica acta · 2016
- Lab dish studyOncogenic Role of the Ec Peptide of the IGF-1Ec Isoform in Prostate Cancer.
Molecular medicine (Cambridge, Mass.) · 2015
- Lab dish studyBiological activity of the e domain of the IGF-1Ec as addressed by synthetic peptides.
Hormones (Athens, Greece) · 2014
- Lab test method, not a health studyMass spectrometric characterization of a biotechnologically produced full-length mechano growth factor (MGF) relevant for doping controls.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2014
- Hypothesis, not a tested studyThe COOH-terminus of the IGF-1Ec Isoform Enhances the Proliferation and Migration of Human MCF-7 Breast Cancer Cells.
Anticancer research · 2017
- Hypothesis, not a tested studyIGF-IEc expression is increased in secondary compared to primary foci in neuroendocrine neoplasms.
Oncotarget · 2017
- Hypothesis, not a tested studyPossible role of the Ec peptide of IGF‑1Ec in cartilage repair.
Molecular medicine reports · 2016
- Fluorescence-Based Multiplex Western Blot to Simultaneously Detect the Insulin-Like Growth Factor-1 (IGF-1) Isoforms.
Electrophoresis · 2025
- Differential Expression of Insulin Growth Factor 1 (IGF-1) Isoforms in Different Types of Endometriosis: Preliminary Results of a Single-Center Study.
Biomolecules · 2023
- Increased expression of IGF-1Ec with increasing colonic polyp dysplasia and colorectal cancer.
Journal of cancer research and clinical oncology · 2020
- Effect of different muscle contraction mode on the expression of Myostatin, IGF-1, and PGC-1 alpha family members in human Vastus Lateralis muscle.
Molecular biology reports · 2020
- Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men.
Journal of cachexia, sarcopenia and muscle · 2019
- IL-6 is associated to IGF-1Ec upregulation and Ec peptide secretion, from prostate tumors.
Molecular medicine (Cambridge, Mass.) · 2018
- Blunted satellite cell response is associated with dysregulated IGF-1 expression after exercise with age.
European journal of applied physiology · 2018
- The intrinsically disordered E-domains regulate the IGF-1 prohormones stability, subcellular localisation and secretion.
Scientific reports · 2018
- Effects of High-Intensity Interval Exercise Training on Skeletal Myopathy of Chronic Heart Failure.
Journal of cardiac failure · 2017
- Review of earlier workThe emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
Frontiers in endocrinology · 2026
- Review of earlier workInsulin-like Growth Factor 1 (IGF1) and Its Isoforms: Insights into the Mechanisms of Endometrial Cancer.
Cancers · 2025
- Review of earlier workDecoding the Role of Insulin-like Growth Factor 1 and Its Isoforms in Breast Cancer.
International journal of molecular sciences · 2024
- Review of earlier workThe role of the IGF-1 Ec in myoskeletal system and osteosarcoma pathophysiology.
Critical reviews in oncology/hematology · 2016
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