P21
Animal studies onlyAlmost all the research is in animals. We do not know if the same thing happens in people.
Also called P021 / Ciliary neurotrophic factor peptide
A small piece of a nerve growth factor. Studied in mice for memory and brain cell growth.
Can a doctor prescribe this?
No. Pharmacies are not on record as being allowed to make this into a medicine.
The FDA has not approved this as a medicine.
Not approved and not on the compounding list.
Official status: Not on the 503A bulks list. Checked 2026-08-04.
Lab suppliers we list: 2
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In human trials
400 mg
Phase I Study of Gene Induction Mediated by Sequential Decitabine/Depsipeptide Infusion With or Without Concurrent Celecoxib in Subjects With Pulmonary and Pleural MalignanciesPHASE1 · NCT00037817
“400mg PO BID on days 4 through 34 of each cycle.”
400 mg
by mouth · once daily · for 7-10 days
A Clinical Trial to Validate Molecular Targets of Vorinostat in Patients With Aerodigestive Tract CancerNA · NCT00735826
“Subjects will receive vorinostat 400 mg once daily on a continuous daily basis for 7 to 10 days prior to surgical resection.”
See source wording
every 28 days
Clinical Research for Azacitidine Combined With Low-dose Dasatinib in Maintenance Therapy of Acute Myeloid LeukemiaNA · NCT05042531
“Azacitidine, 75mg/m2,d1-7;Treatment cycles every 28 days.”
See source wording
by mouth · three times per week
Panobinostat (LBH589) Plus Everolimus (RAD001) in Patients With Relapsed and Refractory LymphomaPHASE1, PHASE2 · NCT00967044
“Starting dose of 10 mg by mouth per day, self-administered (by patients), three times per week.”
In animal studies
See source wording
mice ·
Screening and Activity Profiling of Antisenescence Peptides from Silkworm Pupa Protein Hydrolysate: Discovery of a Bioactive Hexapeptide FKVPNM.Journal of agricultural and food chemistry · 2026
“In d-galactose-induced senescent PC-12 cells, SPPH (1 mg/mL) increased cell viability from 73.5 ± 1.1% (model) to 101.2 ± 0.4% (p < 0.01) and reduced SA-β-gal-positive cells.”
3.541 mmol
mice ·
Genetic haploinsufficiency of POM121 exacerbates ischemia reperfusion injury induced acute kidney injury by promoting p53/p21-mediated cellular senescence.Tissue & cell · 2026
“44.513 ± 3.541 mmol/L), and KIM-1 expression (approximately 1-2-fold increase).”
See source wording
mice ·
Exposure to high doses of tyre antioxidant 6PPD causes senescence to induce unexplained miscarriage by suppressing BAZ1B-mediated ubiquitination degradation of P21.EBioMedicine · 2026
“6PPD-exposed mouse model further confirms that exposure to high doses of 6PPD causes placental senescence (≥12 mg/kg/d) to induce mouse miscarriage (≥36 mg/kg/d).”
- LRRK2-G2019S couples metabolic stress to astrocytic senescence through DDB1-mediated p21 stabilization in Parkinson's disease
Animal study, rats or mice
Journal not recorded · 2026
- Coal Dust-Mimetic Carbon Nanoparticles Induce Colonic Epithelial Cell Senescence via p16/p21 Dual Pathways and Promote Colonic Inflammatory Response.
Animal study, rats or mice
Journal of gastroenterology and hepatology · 2026
- Ubiquitin-specific protease 11 promotes tubular cell senescence via inhibiting p53 ubiquitin degradation during renal fibrosis.
Animal study, rats or mice
Cellular signalling · 2026
- Screening and Activity Profiling of Antisenescence Peptides from Silkworm Pupa Protein Hydrolysate: Discovery of a Bioactive Hexapeptide FKVPNM.
Animal study, rats or mice
Journal of agricultural and food chemistry · 2026
- Genetic haploinsufficiency of POM121 exacerbates ischemia reperfusion injury induced acute kidney injury by promoting p53/p21-mediated cellular senescence.
Animal study, rats or mice
Tissue & cell · 2026
- TERT drives liver tumorigenesis beyond telomere elongation.
Animal study, rats or mice
Life science alliance · 2026
- Dacarbazine Resistance in Melanoma Is Driven by Cell Cycle Dysregulation Stemming from Altered Cyclin D1, GSK-3β, and p21 Expression.
Animal study, rats or mice
Anticancer research · 2026
- AMD1-mediated polyamine metabolism governs tubular repair fate by restraining senescence after kidney injury.
Animal study, rats or mice
Renal failure · 2026
- Targeting p21-High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus.
Animal study, rats or mice
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
- p21-activated kinase 4 drives hepatic stellate cell activation and liver fibrosis through the phosphorylation of YAP at T428.
Animal study, rats or mice
Signal transduction and targeted therapy · 2026
- Pro-Xylane alleviates ultraviolet-induced skin senescence through SGK1-mediated p21 ubiquitination and subcellular translocation.
Animal study, rats or mice
Mechanisms of ageing and development · 2026
- Single-Cell and Multiomics Characterization of p21 in Cancer Progression and Therapeutic Sensitivity.
Lab dish study
Human mutation · 2026
- Exposure to high doses of tyre antioxidant 6PPD causes senescence to induce unexplained miscarriage by suppressing BAZ1B-mediated ubiquitination degradation of P21.
Lab dish study
EBioMedicine · 2026
- p53 and p21 Status Influences Cellular Response to Metformin in <i>KRAS</i>-Mutant HCT116 Colorectal Cancer Cells.
Lab dish study
Current issues in molecular biology · 2026
- Intravesical Delivery of P21 mRNA-Loaded Lipid Nanoparticles as a Tumor Suppressor Replacement Therapy for Bladder Cancer.
Lab dish study
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
- Synthesis and growth inhibitory activity of sinomenine derivatives against cervical cancer SiHa cells through targeting the AKT-CyclinD1-p21/p27 pathway.
Lab dish study
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
- Hepatic Cellular Senescence Is Attenuated by Filbertone via Modulation of the p53-p21 Pathway in AML12 Hepatocytes.
Lab dish study
Nutrients · 2026
- CRISPR/Cas9-mediated miR-155 knockout suppresses glioblastoma cell proliferation through TP53INP1/p53/p21 activation
Lab dish study
Journal not recorded · 2026
- Quercetagetin-rich flavonoids from marigold induce apoptosis inhibit metastasis of non-small cell lung cancer via the p53/p21 signaling pathway.
Lab dish study
Frontiers in oncology · 2026
- Sodium butyrate attenuates D-galactose-induced cellular senescence in WI-38 fibroblasts <i>in vitro</i> via modulation of HDAC activity, Nrf2/ARE pathway, and p53/p21/p16 signaling.
Lab dish study
Frontiers in physiology · 2026
- Regulatory effects of transcription factor PAX3 on human dental pulp stem cells.
Lab dish study
BMC oral health · 2026
- Dihydroxyacetone nanoparticles ameliorate osteoarthritis via P21-mediated regulation of chondrocyte repair.
Journal of nanobiotechnology · 2026
- Single-cell transcriptomics identifies a p21-activated kinase important for survival of the zoonotic parasite <i>Fasciola hepatica</i>.
iScience · 2026
- CASK promotes non-small cell lung cancer growth through coordinated regulation of EGFR expression, trafficking, and p21 expression.
Journal of biomedical science · 2026
- Genomic Disruption of CAMKMT by t(2;11)(p21;q23) Reveals a Glycolytic Reprogramming Mechanism in Acute Myeloid Leukemia.
Current medicinal chemistry · 2026
- CRISPR/Cas9 system-mediated p21 knockout impairs the MITF signaling pathway.
Journal of biotechnology · 2026
- Ubiquitin-dependent degradation of p27Kip1 and p21Waf1/Cip1 by AMBRA1 ensures G1 and S phase progression and limits replication stress.
Nucleic acids research · 2026
- Structural basis for a p21-activated kinase 4 and nicotinamide phosphoribosyltransferase dual inhibitor.
Acta crystallographica. Section D, Structural biology · 2026
- Invasive-Front P21 Expression Is Associated With Tumor Aggressiveness in Head and Neck Squamous Cell Carcinoma.
Anticancer research · 2026
- Transcription-independent induction of rapid-onset senescence is integral to healing.
Nature cell biology · 2026
- Zfp36l1 Inhibits DNA Damage by Regulating p21-E2F1-Rad51 Signaling During Myogenic Differentiation.
International journal of molecular sciences · 2026
- Multiplexed P21/MCM-2 Detection Predicts Relapse and May Identify Tyrosine Kinase Inhibitor-Resistant Patients in Clear Cell Renal Cell Carcinoma.
Cancer research communications · 2026
- Subcellular compartmentalization dependent dichotomy of p21 in cancer.
Review of earlier work
Molecular biology reports · 2026
- CDKN1A/p21 Influences the Survival and Expansion of Breast Cancer Stem Cells after Oxidative Damage.
Review of earlier work
Oncology research · 2026