Oxytocin

In human trials

• See source wording

  into a vein

  Oxytocin, Carbetocin and Misopristol for Treatment of Postpartum Hemorrhage: A Multicentric Randomized TrialNA · NCT01600612

  “10 ug of carbetocin will be given intravenously to patients with atonic postpartum hemorrhage.”

• 24 IU

  nasal spray

  The Influence of Oxytocin on the Processing of Social ContactPHASE1 · NCT01939639

  “24 IU Oxytocin, intranasal application 45 min prior to the experiment.”

• See source wording

  nasal spray

  The Interaction Between Oxytocin and SerotoninNA · NCT03577457

  “intranasal administration of oxytocin (24 IU).”

• 1.9 mg

  single dose

  Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study)NA · NCT05319301

  “A single dose of melatonin (1.9 mg).”

• See source wording

  nasal spray

  Dose-dependent Effects of Oxytocin on the Amygdala and Reward SystemPHASE1 · NCT03846739

  “Oxytocin & Placebo, 6 IU.”

• See source wording

  nasal spray · three times per day · for 56 week

  Phase 3 Study of Intranasal Carbetocin (LV-101) in Patients With Prader-Willi SyndromePHASE3 · NCT03649477

  “3.2 mg intranasal carbetocin.”

• See source wording

  into a vein

  The Role of Oxytocin in Regulating Blood GlucoseNA · NCT06334172

  “Oxytocin 0.1 IU/min.”

• See source wording

  by mouth · for 8 weeks

  Bryophyllum Versus Placebo for Overactive BladderPHASE2 · NCT01127126

  “Comparison Bryophyllum (2100mg/d) against Placebo (2100mg/d) regarding effectivity and safety.”

• 24 IU

  nasal spray · for 5 days

  Intranasal Oxytocin and Learning in AutismPHASE2 · NCT01417026

  “Subjects will be randomized to 24 IU intranasal oxytocin or placebo for a 5 day period with concomitant game play of computer games, which are designed to enhance face perception skills.”

• See source wording

  into a vein

  Effects Of Intravenous Oxytocin On Peripheral Sensory Afferents Using MicroneurographyPHASE2 · NCT07409753

  “Intravenous oxytocin, 20 IU will be administered via two 30-minute infusions separated by 30 minutes.”

• 100 mcg

  for 2 hours

  Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human MyometriumNA · NCT06285409

  “Carbetocin first bolus 10-8 M (equivalent to 100 mcg) will be added to the muscle bath to create ex-vivo environment similar to Cesarean delivery, and after 20 minutes the baths will be washed three time with physiological salt solution (PSS)..”

• See source wording

  nasal spray · twice daily · for 7 days

  Intranasal Oxytocin for Methamphetamine Withdrawal in WomenNA · NCT05760807

  “Participants will receive oxytocin by intranasal spray under clinician supervision (1 insufflation equating to an active dose of 24 IU) twice daily (i.e., 48 IU per day), delivered over 7 days of a residential inpatient withdrawal admission.”

• 5 IU

  into a vein · single dose

  Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by OxytocinPHASE3 · NCT01099280

  “SYNPITAN FORT 5 IU.”

• See source wording

  into a vein

  The Effect of Neuraxial Analgesia on Maternal BreastfeedingNA · NCT01074190

  “Breakthrough pain in all groups will be managed using anesthesiologist administered boluses of bupivacaine 1.25 mg/mL without fentanyl..”

• 1000 mcg

  into a vein

  Effect of Misoprostol in Reducing Post Partum Hemorrhage After Labor Induction by OxytocinNA · NCT02983591

  “Patients will receive 1000 mcg Misoprostol per rectum.”

• 40 IU

  nasal spray · for 13 months

  The Efficacy of a Single Dose of Intranasal Oxytocin in the Prevention of Post Traumatic Stress Disorder (PTSD)NA · NCT01039766

  “A single intranasal administration of 40 IU of oxytocin will be given to patients up to 6 hours after a traumatic event, with consecutive follow up for 13 months..”

• 40 IU

  nasal spray

  Prolonged Exposure and OxytocinPHASE2 · NCT03238924

  “40 IU oxytocin nasal spray, self-administered.”

• See source wording

  nasal spray

  The Interaction Between Oxytocin and SerotoninNA · NCT03426176

  “intranasal administration of oxytocin (24 IU).”

• See source wording

  into a vein

  Carbetocin Versus Oxytocin and Ergometrine for the Prevention of Postpartum Haemorrhage Following Caesarean SectionPHASE4 · NCT02101567

  “Pabal 100 mcg iv infusion over 1 minute given after delivery of fetal head.”

• 40 IU

  nasal spray · for 14 days

  Benefits of Oxytocin in Obstructive Sleep Apnea (OSA) Patients Using Continuous Positive Airway Pressure (CPAP) MachinePHASE1 · NCT03860233

  “40 IU administered intranasal, within 1 hour prior to sleeping for 14 days.”

• See source wording

  nasal spray

  Neuropeptides and Social BehaviorEARLY_PHASE1 · NCT01680718

  “Through the use of 1oz bottles attached with metered nasal pumps (1 puff = .1ml), participants will self-administer 24 IU oxytocin (Syntocinon, Novartis Pharmaceuticals).”

• See source wording

  Carbetocin at Elective Cesarean DeliveryNA · NCT01262742

  “80mcg carbetocin, IV, over 1 minute following delivery of the fetal head..”

• 20 mg

  by mouth

  Does Oral Propranolol Accelerate Labor Induction/Augmentation With Oxytocin in Nulliparous Women in Abakaliki?NA · NCT05251610

  “20mg oral propranolol and oxytocin.”

• 40 IU

  nasal spray

  Oxytocin to Treat PTSDPHASE2 · NCT04228289

  “40 IU intranasal spray.”

• See source wording

  into a vein

  Oxytocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With BMI ≥ 40kg/m2NA · NCT03957083

  “Oxytocin 0.5IU.”

• 4 IU

  nasal spray · every other day

  Evaluation of Tolerance, Suckling and Food Intake After Repeated Nasals Administrations of Oxytocin in PWS InfantsPHASE1, PHASE2 · NCT02205034

  “4IU of oxytocin every other day.”

• See source wording

  by mouth

  Effects of MDMA Co-administration on the Response to LSD in Healthy SubjectsPHASE1 · NCT04516902

  “A moderate dose of 100 μg LSD will be administered..”

• 10 IU

  into a vein

  PK Sampling After IV Oxytocin and Effects on Sensory Function in Healthy VolunteersPHASE4 · NCT03929367

  “Oxytocin (Pitocin®), 10 IU.”

• See source wording

  nasal spray

  Deciphering the Role of Oxytocin in Motivation: an fMRI StudyPHASE2 · NCT01722071

  “Oxytocin intranasal administration, 24 IU, 3 puffs per nostril at 4 IU per puff delivered approximately 30 minutes prior to scanning session..”

• See source wording

  nasal spray

  A Pharmaco-imaging Approach to Predicting Social Functioning and Clinical Responses to Oxytocin Administration in SchizophreniaPHASE2 · NCT03900754

  “Dosages of oxytocin: 20IU or 40IU..”

• See source wording

  by mouth

  Circulating Oxytocin Changes in Response to the Oxytocin System Stimulator MDMA in Patients With Diabetes Insipidus and Healthy ControlsNA · NCT04648137

  “single administration of MDMA (100mg): 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) will be prepared as gelatin capsules with mannitol as the filler.”

• 24 IU

  nasal spray

  Oxytocin's Effects on Emotional Processing and Its Acting RoutesNA · NCT07425938

  “intranasal administration of placebo (24 IU).”

• See source wording

  nasal spray

  Evaluating Intranasal Oxytocin (TNX-1900) for Pain Relief and Recovery After Pituitary SurgeryPHASE2 · NCT07730294

  “The dosage for low -dose intranasal oxytocin is set at 6 International Units (IU) per day, divided into two administrations of 3IU each per nostril.”

• 84 IU

  nasal spray

  Target Engagement for Oxytocin: Dose Ranging StudyNA · NCT02498236

  “Oxytocin 6-84 IU.”

• 40 IU

  nasal spray

  Oxytocin MEG StudyEARLY_PHASE1 · NCT02568709

  “40 IU of the oxytocin will be administered intranasally for a one time dose at the beginning of the visit..”