Orforglipron
Tested in peopleGet notified when the evidence changes.
It has been tested in people, but it is not an approved medicine. The studies are usually small.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-08-04
Also called LY3502970
A once-a-day pill being tested in large human studies for weight loss and type 2 diabetes.
The basics
- What is it?
- Orforglipron is a small molecule that acts on the same receptor as GLP-1 drugs like semaglutide, but it can be swallowed instead of injected. It has been through late-stage human trials.
Official status: Not nominated for 503A compounding · Checked 2026-08-04
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Not FDA approved and not on the U.S. compounding list. A doctor cannot prescribe it.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 3
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Study in peoplePredicting the Long-Term Risk of Type 2 Diabetes and Cardiovascular Disease With Orforglipron in People With Overweight or Obesity: A Post Hoc Analysis of the ATTAIN-1 Trial.
Diabetes, obesity & metabolism · 2026
- Study in peopleOrforglipron Added to Titrated Insulin Glargine in Type 2 Diabetes: The ACHIEVE-5 Randomized Clinical Trial.
JAMA · 2026
- Study in peopleOrforglipron for the treatment of moderate-to-severe obstructive sleep apnea in adults with obesity or overweight: Study design and baseline characteristics of ATTAIN-OSA, a phase 3 trial.
Contemporary clinical trials communications · 2026
- Study in peopleOrforglipron compared with dapagliflozin in adults with type 2 diabetes and inadequate glycaemic control with metformin (ACHIEVE-2): a multicentre, randomised, non-inferiority, open-label, phase 3 trial.
Lancet (London, England) · 2026
- Study in peoplePharmacokinetic Bioequivalence of Orforglipron Tablets and Capsules in Healthy Participants With Obesity or Overweight.
Diabetes, obesity & metabolism · 2026
- Study in peopleOrforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial.
Nature medicine · 2026
- Study in peopleEfficacy and safety of once-daily oral orforglipron compared with oral semaglutide in adults with type 2 diabetes (ACHIEVE-3): a multinational, multicentre, non-inferiority, open-label, randomised, phase 3 trial.
Lancet (London, England) · 2026
- Study in peopleA phase 1 single and multiple ascending dose study of orforglipron in Japanese participants with type 2 diabetes.
Journal of diabetes investigation · 2026
- Study in peopleLong-term safety of oral orforglipron in Japanese participants with type 2 diabetes (ACHIEVE-J): a multicentre, randomised, open-label, parallel-group phase 3 trial.
The lancet. Diabetes & endocrinology · 2026
- Study in peopleOrforglipron for obesity treatment in older patients ≥65 years with or without type 2 diabetes: A post hoc subgroup analysis of the ATTAIN-1 and ATTAIN-2 trials.
Obesity pillars · 2026
- Study in peopleOrforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, randomised, multicentre, placebo-controlled trial.
Lancet (London, England) · 2026
- Study in peopleDisposition and Absolute Bioavailability of Orally Administered Orforglipron in Healthy Participants.
Clinical pharmacology in drug development · 2026
- Study in peopleOrforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment.
The New England journal of medicine · 2025
- Study in peopleOrforglipron, an oral non-peptide glucagon-like peptide-1 receptor agonist, improves markers of β-cell function and insulin sensitivity in type 2 diabetes.
Diabetes, obesity & metabolism · 2025
- Study in peopleOrforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes.
The New England journal of medicine · 2025
- Study in peopleTreatment with orforglipron, an oral glucagon like peptide-1 receptor agonist, is associated with improvements of CV risk biomarkers in participants with type 2 diabetes or obesity without diabetes.
Cardiovascular diabetology · 2025
- Study in peopleEffect of Food Consumption on the Pharmacokinetics, Safety, and Tolerability of Once-Daily Orally Administered Orforglipron (LY3502970), a Non-peptide GLP-1 Receptor Agonist.
Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024
- Study in peopleOrforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: A Phase 1b, multicentre, blinded, placebo-controlled, randomized, multiple-ascending-dose study in people with type 2 diabetes.
Diabetes, obesity & metabolism · 2024
- Study in peopleOrforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: A Phase 1b, multicentre, blinded, placebo-controlled, randomized, multiple-ascending-dose study in people with type 2 diabetes.
Diabetes, obesity & metabolism · 2023
- Study in peopleOrforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: A Phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study in healthy participants.
Diabetes, obesity & metabolism · 2023
- Study in peopleDaily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity.
The New England journal of medicine · 2023
- Study in peopleEfficacy and safety of oral orforglipron in patients with type 2 diabetes: a multicentre, randomised, dose-response, phase 2 study.
Lancet (London, England) · 2023
- Animal study, rats or miceOrforglipron alleviates aortic aneurysm and dissection via inhibiting WNT5A noncanonical signaling.
Biochemical pharmacology · 2026
- Animal study, rats or miceGeneration and characterisation of a humanised GLP-1 receptor mouse model for translational drug development.
EBioMedicine · 2026
- Animal study, rats or miceDiscovery of Small-Molecule GLP‑1 Receptor Agonists with Improved Oral Pharmacokinetics Based on Orforglipron.
ACS medicinal chemistry letters · 2026
- Animal study, rats or miceThe pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron.
Science translational medicine · 2024
- Animal study, rats or miceStructural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist.
Proceedings of the National Academy of Sciences of the United States of America · 2020
- Lab dish studyOrforglipron, a Small-Molecule Glucagon-like Peptide-1 Receptor Agonist (GLP-1RA), Has Neuroprotective and Anti-Inflammatory Effects.
Cells · 2026
- Drug information page, not a studyOrforglipron
2012
- Drug information page, not a studyOrforglipron
2006
- No abstract available, not yet classifiedKeeping the weight off: can oral orforglipron maintain all the weight loss following glucagon-like peptide-1 receptor agonist (GLP-1 RA) discontinuation?
Expert review of clinical pharmacology · 2026
- Orforglipron: A Comprehensive Review of an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity and Type 2 Diabetes.
International journal of molecular sciences · 2026
- Orforglipron: First Approval.
Drugs · 2026
- Hepatic Safety of Orforglipron in Adults With Obesity or Overweight and/or Type 2 Diabetes: A Pooled Analysis of the Orforglipron Phase 3 Clinical Trials.
Diabetes, obesity & metabolism · 2026
- Clinical Characterization of Enzyme and Transporter Precipitants to Evaluate Drug-Drug Interactions for Orforglipron, a Small Molecule Glucagon-Like Peptide-1 Receptor Agonist.
Clinical pharmacology and therapeutics · 2026
- Oral Semaglutide 25 mg Versus Orforglipron 36 mg in Obesity: A Population-Adjusted Indirect Treatment Comparison.
Diabetes, obesity & metabolism · 2026
- Variant-specific pharmacophoric shifts in glucagon-like peptide-1 receptor-orforglipron complexes revealed by Boltz-2 co-folding and membrane molecular dynamics.
International journal of biological macromolecules · 2026
- In T2D inadequately controlled with metformin, orforglipron reduced HbA<sub>1c</sub> more than oral semaglutide at 52 wk.
Annals of internal medicine · 2026
- No abstract available, not yet classifiedMazdutide and Orforglipron-New Evidence in Obesity and Diabetes.
JAMA · 2026
- No abstract available, not yet classifiedOrforglipron Added to Titrated Insulin Glargine in Type 2 Diabetes: Research Summary.
JAMA · 2026
- No abstract available, not yet classifiedOrforglipron Calcium.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2026
- No abstract available, not yet classifiedOrforglipron (Foundayo) for adults with obesity.
Trends in pharmacological sciences · 2026
- No abstract available, not yet classifiedOrforglipron (Foundayo) - a second oral GLP-1 receptor agonist for weight loss.
The Medical letter on drugs and therapeutics · 2026
- No abstract available, not yet classifiedMethodological and statistical inconsistencies compromise the efficacy and safety analyses of orforglipron.
Acta diabetologica · 2026
- No abstract available, not yet classifiedSafety and tolerability of orforglipron in Japanese people with type 2 diabetes.
The lancet. Diabetes & endocrinology · 2026
- No abstract available, not yet classifiedFast-tracked innovation: orforglipron approval under the FDA's National Priority Voucher program.
Annals of medicine and surgery (2012) · 2026
- The role of GLP-1 and GIP receptor agonists in the treatment of diabetes and obesity.
Pharmacological research · 2026
- Orforglipron and the Kidney: A Promise or Disappointment? The Need for Trials Examining Renal Outcomes.
American journal of nephrology · 2026
- Orforglipron: An Oral GLP-1 Receptor Agonist for Obesity Treatment.
The Annals of pharmacotherapy · 2026
- Orforglipron: A Novel Oral GLP-1 Agonist for the Treatment of Obesity and Diabetes.
Cardiology in review · 2025
- In early T2D inadequately controlled with diet and exercise, once-daily orforglipron reduced HbA<sub>1c</sub> vs. placebo at 40 wk.
Annals of internal medicine · 2025
- Review of earlier workOral small-molecule GLP-1 receptor agonists: a new Frontier in cardiometabolic medicine.
Frontiers in pharmacology · 2026
- Review of earlier workComparative Efficacy and Safety of Different Orforglipron Doses in Patients With Type 2 Diabetes Mellitus and Obesity: A Systematic Review and Network Meta-Analysis.
Cureus · 2026
- Review of earlier workEfficacy and safety of orforglipron, an oral small-molecule GLP-1 receptor agonist, on cardiometabolic outcomes: a meta-analysis and systematic review.
Cardiovascular diabetology. Endocrinology reports · 2026
- Review of earlier workExploratory Cardiovascular Risk Modeling of Orforglipron Using the PREVENT Equations Compared with the Pooled Cohort Equations: A Post-Hoc Analysis from a Systematic Review and Meta-analysis.
High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
- Review of earlier workEfficacy and safety of orforglipron in obesity with type 2 diabetes mellitus: a GRADE-assessed meta-analysis of randomized controlled trials.
Diabetology & metabolic syndrome · 2026
- Review of earlier workComparative Positioning of Orforglipron Among Selected GLP-1 Receptor Agonist Benchmarks: A Narrative Review.
Cureus · 2026
- Review of earlier workMetabolic and Glycemic Effects of Orforglipron, a GLP-1 Receptor Agonist, in Adults With or Without Diabetes: A Network Meta-Analysis of Randomised Clinical Trials.
Endocrinology, diabetes & metabolism · 2026
- Review of earlier workOrforglipron and the emergence of oral GLP-1 therapy for obesity: efficacy, safety, and clinical positioning.
Expert opinion on pharmacotherapy · 2026
- Review of earlier workCardiometabolic Profiles of Oral and Subcutaneous Glucagon-Like Peptide-1 Receptor Mono-Agonists in Adults With Overweight or Obesity: A Systematic Review and Network Meta-Analysis.
Diabetes, obesity & metabolism · 2026
- Review of earlier workThe Gastrointestinal Safety of Orforglipron, a GLP-1 Receptor Agonist, in Adults With or Without Type 2 Diabetes: A Network Meta-Analysis of Randomized Controlled Trials.
Endocrinology, diabetes & metabolism · 2026
- Review of earlier workComparative effects of drugs for adults with overweight or obesity: systematic review and network meta-analysis.
BMJ (Clinical research ed.) · 2026
- Review of earlier workEfficacy and Safety of Oral GLP-1 RA Orforglipron on Weight and Glycemic Control According to Diabetes Status: A Systematic Review and Meta-Analysis.
Diabetes technology & therapeutics · 2026
- Review of earlier workRole of Oral Glucagon-Like Peptide-1 Receptor Agonists in Weight Management for Individuals With Overweight or Obesity Without Diabetes: A Network Meta-Analysis of Randomized Controlled Trials.
Obesity science & practice · 2026
- Review of earlier workPotential nephroprotective mechanisms of orforglipron, an oral non-peptide GLP-1 receptor agonist.
Frontiers in pharmacology · 2026
- Review of earlier workEfficacy and safety of incretin-based therapies in patients with type 2 diabetes mellitus: a network meta-analysis based on clinical trials.
Frontiers in pharmacology · 2026
- Review of earlier workOral Incretin-Based Therapies for Weight Management.
Current atherosclerosis reports · 2026
- Review of earlier work<span data-teams="true">Efficacy and Safety of Oral Small-Molecule (Non-Peptide) GLP-1 Receptor Agonists in Type 2 Diabetes and Obesity: A Systematic Review of the Complete Orforglipron and Danuglipron Clinical Development Programs
2026
- Review of earlier workEfficacy and safety of orforglipron 12 mg versus orforglipron 36 mg maintenance dose among patients with obesity with or without diabetes: a systematic review and comprehensive meta-analysis.
BMC endocrine disorders · 2026
- Review of earlier workOrforglipron in type 2 diabetes mellitus and obesity: an overview.
Expert review of clinical pharmacology · 2025
- Review of earlier workEfficacy and Safety of Orforglipron in Obese Adults With or Without Diabetes: A Systematic Review and Meta-Analysis.
Endocrinology, diabetes & metabolism · 2025
- Review of earlier workOrforglipron, a novel non-peptide oral daily glucagon-like peptide-1 receptor agonist as an anti-obesity medicine: A systematic review and meta-analysis.
Obesity science & practice · 2024
- Review of earlier workSafety and efficacy of the new, oral, small-molecule, GLP-1 receptor agonists orforglipron and danuglipron for the treatment of type 2 diabetes and obesity: systematic review and meta-analysis of randomized controlled trials.
Metabolism: clinical and experimental · 2023
Spot an error? corrections@peptidesearch.org