Orexin-B
Animal studies onlyAlmost all the research is in animals. We do not know if the same thing happens in people.
Also called Hypocretin-2
A brain signalling peptide involved in staying awake and in appetite. Animal research.
The basics
- What is it?
- Orexin-B is one of two orexin peptides the brain makes to control wakefulness, appetite and arousal. Loss of orexin signalling is linked to narcolepsy.
Can a doctor prescribe this?
No. Pharmacies are not on record as being allowed to make this into a medicine.
The FDA has not approved this as a medicine.
Not FDA approved and not on the U.S. compounding list. A doctor cannot prescribe it.
Official status: Not on the 503A bulks list. Checked 2026-08-04.
Lab suppliers we list: 2
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In human trials
See source wording
for 8 weeks
Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 TrialPHASE4 · NCT06093126
“Lemborexant 5 MG.”
In animal studies
30 mcg/kg/day
mice · for 7 weeks
Orexin B Reduces Cerebral Aneurysms Through Inhibition of SP-1.CNS neuroscience & therapeutics · 2026
“A murine CA model (elastase-induced) was established using wild-type (WT) and OX2R knockout (OX2R -/- ) mice, with or without Orexin B treatment (30 μg/kg/day for 7 weeks).”
60 mg/kg
rats ·
Exploring the role of orexin B-sirtuin 1-HIF-1α in diabetes-mellitus induced vascular endothelial dysfunction and associated myocardial injury in rats.Life sciences · 2020
“Material and methods Streptozotocin (60 mg/kg) was employed to induce diabetes mellitus in male Wistar albino rats, which were kept for eight weeks.”
5 mg/kg
mice ·
7,8-Dihydroxyflavone reduces sleep during dark phase and suppresses orexin A but not orexin B in mice.Journal of psychiatric research · 2015
“Baseline polysomnograph recording was performed for 24 h followed by treatment with either 5 mg/kg of DHF or vehicle at the beginning of the dark phase.”
See source wording
rats · into a vein
Involvement of Neuropeptide Orexin B in Basolateral Amygdala Mediated Consummatory Behaviour in Male Wistar Albino Rats.Indian journal of physiology and pharmacology · 2015
“Materials and methods Adult male Wistar albino rats were selected and grouped into control, sham operated control and experimental groups (n = 6 each) Orexin was infused in two doses (3 nmol/µl, 30 nmol/ µl) and TCS-OX2-29 (10 µg/µl) was infused in another group.”
- Intermittent High-Fructose Corn Syrup Consumption Induces Hippocampal Degeneration and Orexin Dysregulation Despite Moderate Exercise Training
Animal study, rats or mice
Journal not recorded · 2026
- Orexin B Reduces Cerebral Aneurysms Through Inhibition of SP-1.
Animal study, rats or mice
CNS neuroscience & therapeutics · 2026
- Sexually dimorphic mediation of experimental post-traumatic headache by orexin receptor signaling.
Animal study, rats or mice
Pain · 2026
- The protective effects of orexin B in neuropathic pain by suppressing inflammatory response.
Animal study, rats or mice
Neuropeptides · 2024
- Orexin B protects dopaminergic neurons from 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity associated with reduced extracellular signal-regulated kinase phosphorylation.
Animal study, rats or mice
Molecular biology reports · 2024
- Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development.
Animal study, rats or mice
Peptides · 2023
- Does Orexin B-Binding Receptor 2 for Orexins Regulate Testicular and Epididymal Functions in Normal and Cryptorchid Dogs?
Dog study
Frontiers in veterinary science · 2022
- Orexin-B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor disorders in MPTP parkinsonian mice.
Animal study, rats or mice
Neuroscience letters · 2021
- Exploring the role of orexin B-sirtuin 1-HIF-1α in diabetes-mellitus induced vascular endothelial dysfunction and associated myocardial injury in rats.
Animal study, rats or mice
Life sciences · 2020
- Role of Orexin-B/Orexin 2 receptor in myocardial protection.
Animal study, rats or mice
Clinical science (London, England : 1979) · 2019
- Localization of orexin B and orexin-2 receptor in the rat epididymis.
Animal study, rats or mice
Acta histochemica · 2018
- Orexin-B modulates synaptic transmission of rod bipolar cells in rat retina.
Animal study, rats or mice
Neuropharmacology · 2018
- Orexin B Modulates Spontaneous Excitatory and Inhibitory Transmission in Lamina II Neurons of Adult Rat Spinal Cord.
Animal study, rats or mice
Neuroscience · 2018
- Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection.
Animal study, rats or mice
Clinical science (London, England : 1979) · 2018
- Expression of orexin B and its receptor 2 in rat testis.
Animal study, rats or mice
General and comparative endocrinology · 2017
- 7,8-Dihydroxyflavone reduces sleep during dark phase and suppresses orexin A but not orexin B in mice.
Animal study, rats or mice
Journal of psychiatric research · 2015
- Involvement of Neuropeptide Orexin B in Basolateral Amygdala Mediated Consummatory Behaviour in Male Wistar Albino Rats.
Animal study, rats or mice
Indian journal of physiology and pharmacology · 2015
- The action of orexin B on passive avoidance learning. Involvement of neurotransmitters.
Animal study, rats or mice
Behavioural brain research · 2014
- orexin B alleviates sepsis-associated lung injury through the attenuation of pulmonary endothelial barrier dysfunction by regulating the rho-associated coiled-coil containing protein kinase 2/zonula occludens-1 (ROCK2/ZO-1) axis.
Lab dish study
Biotechnology and applied biochemistry · 2025
- In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B.
Lab dish study
Cellular and molecular life sciences : CMLS · 2024
- Orexin B affects the transcriptome of incubated in vitro porcine endometrial explants from the early-implantation period.
Lab dish study
Reproduction in domestic animals = Zuchthygiene · 2021
- The effect of orexin B on steroidogenic acute regulatory protein, P450 side-chain cleavage enzyme, and 3β-hydroxysteroid dehydrogenase gene expression, and progesterone and androstenedione secretion by the porcine uterus during early pregnancy and the estrous cycle.
Lab dish study
Journal of animal science · 2019
- Orexin A but not orexin B regulates lipid metabolism and leptin secretion in isolated porcine adipocytes.
Lab dish study
Domestic animal endocrinology · 2018
- Crucial role of the orexin-B C-terminus in the induction of OX1 receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis.
Lab dish study
British journal of pharmacology · 2015
- Peripheral orexin system alterations in acute bipolar mania: Associations with clinical features and diagnostic performance.
Measured levels in people, no peptide given
Journal of affective disorders · 2026
- Orexin receptor 2 (OX<sub>2</sub>R) exhibits ligand-dependent spatio-temporal pharmacology through Gα<sub>i</sub>:β-arrestin dynamics in response to Orexin-A and Orexin-B.
Biochemical pharmacology · 2026
- Mass Spectrometry-Based Quantification of Orexin Species in Human Cerebrospinal Fluid Reveals Differential Dynamics Associated with Sleep
Journal not recorded · 2025
- Circular Dichroism Study of Orexin B under Oxidative Stress Conditions.
Molecules (Basel, Switzerland) · 2023
- A photocaged orexin-B for spatiotemporally precise control of orexin signaling.
Cell chemical biology · 2022
- Orexin B inhibits viability and differentiation of stromal cells from swine adipose tissue.
Domestic animal endocrinology · 2021
- Effects of Orexin B on Swine Granulosa and Endothelial Cells.
Animals : an open access journal from MDPI · 2021
- The influence of orexin B on the transcriptome profile of porcine myometrial explants during early implantation.
Theriogenology · 2020
- Orexin-B-like immunoreactivity in pituitary αMSH-producing cells and median eminence GnRH-containing fibres of the flat-tailed house gecko.
Anatomia, histologia, embryologia · 2019
- Effect of orexin B on CYP17A1 and CYP19A3 expression and oestradiol, oestrone and testosterone secretion in the porcine uterus during early pregnancy and the oestrous cycle.
Animal : an international journal of animal bioscience · 2018
- The Subthalamic Neurons are Activated by Both Orexin-A and Orexin-B.
Neuroscience · 2018
- Adiponectin, orexin A and orexin B concentrations in the serum and uterine luminal fluid during early pregnancy of pigs.
Animal reproduction science · 2017
- Localization of orexin B and receptor 2 for orexins in testicular cytotypes of the camelid alpaca (Vicugna pacos).
Reproduction in domestic animals = Zuchthygiene · 2017
- Locomotor activity and the expression of orexin A and orexin B in aged female rhesus macaques.
Neurobiology of aging · 2017
- Localization of orexin A and orexin B in the porcine uterus.
Reproductive biology · 2012
- The orexinergic system in the retina: Expression and physiological impact-A review of the literature.
Review of earlier work
Frontiers in neuroendocrinology · 2026
- The Neural Network of Orexin-A: Implications in Feeding Regulation and Obesity-Anxiety Comorbidity.
Review of earlier work
Brain sciences · 2026
- Lateral hypothalamic orexinergic neurons as central mediators of pain modulation and non-pharmacological analgesia.
Review of earlier work
Frontiers in pharmacology · 2026
- Neuroendocrine Control of the Testis: Focus on Orexinergic Modulation of Spermatogenesis.
Review of earlier work
The Journal of comparative neurology · 2026
- Physiological significance of autocrine orexinergic signaling in extra-hypothalamic tissues.
Review of earlier work
Physiological reports · 2026