MK-677
Tested in peopleIt has been tested in people, but it is not an approved medicine. The studies are usually small.
Also called Ibutamoren / Ibutamoren mesylate / MK-0677 / Nutrobal
A pill, not a peptide. Raises growth hormone and IGF-1. Tested in people but never approved.
Can a doctor prescribe this?
No. Pharmacies are not on record as being allowed to make this into a medicine.
The FDA has not approved this as a medicine.
Reviewed by the FDA's advisory panel in October 2024 and not recommended for the compounding list.
Official status: Not on the 503A bulks list. Checked 2024-10-29.
Lab suppliers we list: 9
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In human trials
25 mg
by mouth · daily
The Impact of Ibutamoren on Nonalcoholic Fatty Liver DiseasePHASE2 · NCT05364684
“Open-label study of oral LUM-201 (ibutamoren mesylate) 25mg daily in otherwise healthy adults with BMI ≥25 kg/m2 and histologic or radiologic diagnosis of NAFLD.”
In animal studies
4 mg/kg
rats · by mouth · for 6 weeks
Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats.Yonsei medical journal · 2018
“Body weight, body length, tibia length, epiphyseal plate width, and serum levels of insulin-like growth factor (IGF)-I were measured after oral administration of 4 mg/kg of MK-677 for 6 weeks to investigate growth-promoting effects.”
- Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial.
Study in people
Neurology · 2008
- Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women.
Study in people
The Journal of clinical endocrinology and metabolism · 2001
- Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group.
Study in people
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 1999
- Discrepancy between serum leptin values and total body fat in response to the oral growth hormone secretagogue MK-677.
Study in people
Clinical endocrinology · 1999
- Treatment of obese subjects with the oral growth hormone secretagogue MK-677 affects serum concentrations of several lipoproteins, but not lipoprotein(a).
Study in people
The Journal of clinical endocrinology and metabolism · 1999
- MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism.
Study in people
The Journal of clinical endocrinology and metabolism · 1998
- Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man.
Study in people
Neuroendocrinology · 1997
- Acute stress suppresses hunger-driven food seeking through PVN activation: Reversal by anxiolytic drug and ghrelin receptor agonist, with anxiolytic-like effects of refeeding.
Animal study, rats or mice
Neuroscience research · 2026
- Brain and kidney GHS-R1a underexpression is associated with changes in renal function and hemodynamics during neurogenic hypertension.
Animal study, rats or mice
Molecular and cellular endocrinology · 2020
- Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats.
Animal study, rats or mice
Yonsei medical journal · 2018
- Reversible Gynecomastia and Hypogonadism Due to Usage of Commercial Performance-Enhancing Supplement Use.
Lab dish study
JCEM case reports · 2024
- Equine metabolism of the growth hormone secretagogue MK-0677 in vitro and in urine and plasma following oral administration.
Lab dish study
Drug testing and analysis · 2022
- Knowing the minimal detectable dose can facilitate the interpretation of a hair test result: II. Case example with ibutamoren (MK-677), a growth hormone secretagogue.
Clinica chimica acta; international journal of clinical chemistry · 2026
- Hepatotoxicity induced by MK-677.
BMJ case reports · 2025
- LGD-4033 and MK-677 use impacts body composition, circulating biomarkers, and skeletal muscle androgenic hormone and receptor content: A case report.
Experimental physiology · 2022
- The Safety and Efficacy of Growth Hormone Secretagogues.
Sexual medicine reviews · 2018
- The effect of treatment with the oral growth hormone (GH) secretagogue MK-677 on GH isoforms.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2003
- Spontaneous Splenic Rupture in a Patient With Recent Use of Performance-Enhancing Compounds: A Case Report and Literature Review.
Review of earlier work
Cureus · 2026