Melanotan II

In animal studies

These are doses given to animals, usually per kilogram of body weight. They do not convert directly to a human dose.

• 60 nmol/kg

  rats · another route · daily

  Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.European journal of pharmacology · 2024

  “Stressed and control male adult Sprague-Dawley rats received daily intraperitoneal injections of saline or a low dose (60 nmol/kg of body weight (BW)) of Semax or MTII.”

• 1 nmol

  mice ·

  Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.Neuropeptides · 2022

  “Methods Male, C57BL/6J mice were microinjected bilaterally into the NAcc (100 nl/side) with the melanocortin receptor 3/4 agonist melanotan-II (MT-II; 0.1, 0.3, and 1 nmol), and ingestive behaviors were examined in both home cage and operant food self-administration experiments.”

• 1 nmol

  mice ·

  Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for foodJournal not recorded · 2022

  “Methods Male, C57BL/6J mice were microinjected bilaterally into the NAcc (100 nl/side) with the melanocortin receptor 3/4 agonist melanotan-II (MT-II; 0.1, 0.3, and 1 nmol), and ingestive behaviors were examined in both home cage and operant food self-administration experiments.”

• 0.26 mg/kg

  mice ·

  Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice.Alcoholism, clinical and experimental research · 2015

  “Results Both NAL and MTII blunt binge-like EtOH drinking and associated blood EtOH levels, and when administered together, a low dose of MTII (0.26 mg/kg) produces a 7.6-fold increase in the effectiveness of NAL in reducing binge-like EtOH drinking.”

• 1 mcg

  mice · into a vein

  The protective effects of the melanocortin receptor (MCR) agonist, melanotan-II (MTII), against binge-like ethanol drinking are facilitated by deletion of the MC3 receptor in mice.Neuropeptides · 2014

  “Wild-type MC3R+/+ and MC3R-/- mice were given intracerebroventricular (i.c.v.) infusion of MTII (0.0, 0.25, 0.50, or 1.0 μg) prior to the onset of a 4-h testing period in which mice were given access to 20% (v/v) ethanol.”

• See source wording

  mice ·

  Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.American journal of physiology. Endocrinology and metabolism · 2012

  “Therefore, we examined the effects of hindbrain administration (4th ventricle) of leptin (1.5, 3, and 6 μg) or the melanocortin 3/4R agonist melanotan II (0.1 and 0.2 nmol) in POMC-Ptp1b(-/-) (KO) and control PTP1B(fl/fl) (WT) mice on food intake, body weight, spontaneous physical activity (SPA), and core temperature (T(C)).”

• See source wording

  rats ·

  5-HT(2C) receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin and melanotan-II in rats.European journal of pharmacology · 2008

  “SB200646 at 10 mg/kg and SB242084 at 3 mg/kg, these doses which completely antagonize penile erections induced by 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP) and (S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-methylethylamine (YM348), significantly inhibited penile erections elicited by apomorphine, oxytocin or MT-II.”

• 2 mg/kg

  rats · single dose

  Effects of melanotan II, a melanocortin agonist, on grooming and exploration in rats after repeated restraint/immobilization.Neuroscience letters · 2008

  “2mg/kg melanotan II (MTII, administered i.p.), a cyclic peptide analog of alpha-melanocyte stimulating hormone, at a single dose increased grooming in naive rats placed in an unfamiliar open-field device without changing locomotion or rearing.”

• 3 mg/kg

  rats · into a vein

  The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat.Pharmacology, biochemistry, and behavior · 2006

  “MT-II (1 and 3 mg/kg) or saline was injected intravenously 10 min before each 30-min paced mating test.”

• 1 mg/kg

  rats ·

  Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized rat.Neuroscience · 2006

  “(0.1, 0.3 and 1 mg/kg) or within the paraventricular nucleus of the hypothalamus (0.1 and 1 microg), melanotan-II exerted a dose-dependent inducer activity on erection by eliciting erectile events and shortening latency of the first erectile event to occur.”

• 1 mg/kg

  rats · into a vein

  The use of telemetry technology to test the proerectile effect of melanotan-II (MT-II) in conscious rats.European urology · 2005

  “Methods Adult rats were implanted in the corpus cavernosum with a pressure sensor which permitted telemetric monitoring of ICP in freely moving animals following MT-II (0.1, 0.3 and 1 mg/kg) or saline i.v.”

• 225 ng

  mice · into a vein

  Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice.Diabetologia · 2005

  “Methods Over a period of 24 h, 225 ng of MTII was injected in three aliquots into the left lateral ventricle of male C57Bl/6 mice.”