Matrixyl
Tested in peopleIt has been tested in people, but it is not an approved medicine. The studies are usually small.
Also called Palmitoyl Pentapeptide-4 / Pal-KTTKS / Matrixyl 3000
A skincare ingredient studied for boosting collagen. Found in many over-the-counter creams.
Can a doctor prescribe this?
No. Pharmacies are not on record as being allowed to make this into a medicine.
The FDA has not approved this as a medicine.
Sold as a cosmetic ingredient, which is regulated differently from drugs.
Official status: Not on the 503A bulks list. Checked 2026-08-04.
Lab suppliers we list: 3
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
No dosing information has been published in the research indexed here.
- Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet.
Study in people
The Journal of clinical and aesthetic dermatology · 2023
- Self-Assembly and Wound Healing Activity of Biomimetic Cycloalkane-Based Lipopeptides.
Animal study, rats or mice
ACS applied materials & interfaces · 2024
- N-Terminal Acetylation and C-Terminal Amidation of <i>Spirulina platensis</i>-Derived Hexapeptide: Anti-Photoaging Activity and Proteomic Analysis.
Animal study, rats or mice
Marine drugs · 2019
- Synergistic Effects of Injectable Platelet-Rich Fibrin and Bioactive Peptides on Dermal Fibroblast Viability and Extracellular Matrix Gene Expression: An In Vitro Study.
Lab dish study
Molecules (Basel, Switzerland) · 2025
- Dually functionalized dendrimer for stimuli-responsive release of active ingredients into the skin.
Lab dish study
Acta biomaterialia · 2025
- Boosting Cosmeceutical Peptides: Coupling Imidazolium-Based Ionic Liquids to Pentapeptide-4 Originates New Leads with Antimicrobial and Collagenesis-Inducing Activities.
Lab dish study
Microbiology spectrum · 2022
- The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic Activity.
Lab dish study
Molecules (Basel, Switzerland) · 2019
- Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis.
Cureus · 2026
- Constrained Evolutionary Design of Matrixyl Analogs: Balancing Permeability and Functional Preservation Through Computational Optimization
Journal not recorded · 2026
- Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides.
Journal of peptide science : an official publication of the European Peptide Society · 2026
- Matrixyl Patch vs Matrixyl Cream: A Comparative In Vivo Investigation of Matrixyl (MTI) Effect on Wound Healing.
ACS omega · 2022
- Turning a Collagenesis-Inducing Peptide Into a Potent Antibacterial and Antibiofilm Agent Against Multidrug-Resistant Gram-Negative Bacteria.
Frontiers in microbiology · 2019
- A framework for the safety evaluation of peptides in cosmetics.
Review of earlier work
Current research in toxicology · 2026