Liraglutide
Approved medicineGet notified when the evidence changes.
The FDA has approved a version of this as a medicine, so it has been through large studies in people.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-04-30
Also called Saxenda / Victoza / NN2211
An approved daily injection for weight loss and type 2 diabetes.
Official status: Not nominated for 503A compounding · Checked 2026-04-30
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Approved and prescription-only. In April 2026 the FDA proposed removing it from the list large-scale compounders may use.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
This is a sample, not the whole literature.
About 21,000 papers mentioning this compound have been published. We show a selected sample of 110 of them, not the full literature. How we choose them · count checked 2026-08-23
- Study in peopleAppetite Suppression by GLP-1 Receptor Agonists: Role of Delayed Gastric Emptying.
Obesity (Silver Spring, Md.) · 2026
- Study in peopleEffects of liraglutide treatment for 35-days on total and regional fat free, lean, and bone mass, and on the Myostatin-Activin-Follistatin-IGF-1 axes: a secondary analysis of a randomized placebo-controlled crossover study.
Diabetes research and clinical practice · 2026
- Study in peopleComparison of the Continuous Glucose Monitoring Profiles of Four Glucose-Lowering Medications in the GRADE Randomized Trial.
Diabetes care · 2026
- Study in peopleProteomic effects of short-term liraglutide vs. placebo in a blinded crossover RCT: Implications for efficacy, safety, and comparison with semaglutide.
Metabolism: clinical and experimental · 2026
- Study in peopleEffects of exercise and liraglutide on vascular health and inflammation during weight loss maintenance: a prespecified secondary analysis of the S-LiTE trial.
Nature metabolism · 2026
- Study in peoplePhysical Fitness with Exercise and GLP-1 Receptor Agonist Treatment Alone or Combined After Diet-Induced Weight Loss: A Secondary Analysis of a Randomized Controlled Trial in Adults with Obesity.
Sports medicine (Auckland, N.Z.) · 2026
- Study in peopleModulation of circulating extracellular vesicles by antihyperglycemic therapies: A pilot randomized controlled trial.
Journal of diabetes and its complications · 2026
- Study in peopleEffects of liraglutide treatment for 18 days on metabolic parameters, regional body composition and the myostatin-activin-follistatin-IGF-1 axis: Results from an exploratory, randomized, placebo-controlled, crossover study.
Diabetes, obesity & metabolism · 2026
- Study in peopleLiraglutide in Acute Minor Ischemic Stroke or High-Risk Transient Ischemic Attack With Type 2 Diabetes: The LAMP Randomized Clinical Trial.
JAMA internal medicine · 2026
- Study in peopleLiraglutide in mild to moderate Alzheimer's disease: a phase 2b clinical trial.
Nature medicine · 2026
- Study in peopleLiraglutide and Recurrent Stroke by Baseline Insulin Resistance: A Post Hoc Analysis of the LAMP Trial.
Stroke · 2026
- Study in peopleSix-month effects of liraglutide and dapagliflozin on lipid profile, cardiovascular risk, and NT-proBNP levels in patients with metabolic dysfunction-associated steatotic liver disease.
Wiadomosci lekarskie (Warsaw, Poland : 1960) · 2026
- Study in peoplePreventive effect of liraglutide on postoperative delirium in elderly patients undergoing cardiac surgery: protocol for a single-centre, randomised, double-blind, placebo-controlled trial.
BMJ open · 2026
- Study in peopleOne Year of Exercise After Weight Loss Increases Postprandial GLP-1 Secretion in Contrast to Usual Activity or GLP-1 Receptor Agonist Treatment.
Obesity (Silver Spring, Md.) · 2026
- Study in peopleDifferential Longitudinal Effects of Glucose-Lowering Medications on Glucagon and C-peptide Responses in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Diabetes care · 2026
- Study in peopleCombination metformin and liraglutide in PCOS: clinical efficacy in women and preclinical insights from gut microbiome modulation in rats.
Frontiers in endocrinology · 2025
- Study in peopleThe influence of the glucagon-like peptide-1 receptor agonist, liraglutide, on dietary patterns and nutrient intakes in patients with obesity and prediabetes: A secondary analysis of a randomized controlled trial.
Diabetes, obesity & metabolism · 2025
- Study in peopleDifferences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-Lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort.
Diabetes care · 2025
- Study in peopleSystemic and gut microbiome changes with metformin and liraglutide in youth-onset type 2 diabetes: the MIGHTY study.
Gut microbes · 2025
- Study in peopleEffect of liraglutide on depressive symptoms in overweight or obese patients with type 2 diabetes: protocol for a pilot randomized controlled trial.
Frontiers in endocrinology · 2025
- Study in peopleA randomized phase I study of BI 1820237, a novel neuropeptide Y receptor type 2 agonist, alone or in combination with low-dose liraglutide in otherwise healthy men with overweight or obesity.
Diabetes, obesity & metabolism · 2025
- Study in peopleDapagliflozin restores odour-induced functional integration of primary olfactory cortex circuit but not olfactory-related regional brain activation in patients with type 2 diabetes: A 16-week randomised comparative study.
Diabetes, obesity & metabolism · 2025
- Study in peopleLiraglutide and Weight Loss Among Suboptimal Responders to Metabolic Bariatric Surgery: A Randomized Clinical Trial.
JAMA network open · 2025
- Study in peopleComparative Efficacy of Endoscopic Sleeve Gastroplasty (Esg) Versus Liraglutide in Weight Loss and Remission Of Obesity-Related Comorbidities: Twelve Months Follow-Up Results.
Obesity surgery · 2025
- Study in peopleAssociation of Hospitalizations With Randomized Glycemia-Lowering Treatment in GRADE.
Diabetes care · 2025
- Study in peopleInsulin DEgludec/LIraglutide versus multiple daily insulin injections in the transition from hospital to outpatient management assessed by continuous glucose monitoring: the DELI transition trial.
Diabetologia · 2025
- Study in peopleFeatures of binge eating disorder in obese or overweight individuals with stable bipolar disorder participating in a weight loss trial - a post hoc analysis.
International journal of psychiatry in clinical practice · 2025
- Study in peopleAnalysis of the Efficacy of Polyenyl Phosphatidylcholine in Combination with Liraglutide in Nonalcoholic Fatty Liver Disease and the Effect of Omentin-1 and Vaspin Expression.
Alternative therapies in health and medicine · 2025
- Study in peopleEvaluating the effects of liraglutide, empagliflozin and linagliptin on mild cognitive impairment remission in patients with type 2 diabetes (LIGHT-MCI): study protocol for a multicentre, randomised controlled trial with an extension phase.
BMJ open · 2025
- Study in peopleLiraglutide improves peripheral perfusion and markers of angiogenesis and inflammation in people with type 2 diabetes and peripheral artery disease: An 18-month follow-up of a randomized clinical trial.
Diabetes, obesity & metabolism · 2025
- Study in peopleWeight Gain Was Associated With Worsening Glycemia and Cardiovascular and Kidney Outcomes in Patients With Type 2 Diabetes Independent of Diabetes Medication in the GRADE Randomized Controlled Trial.
Diabetes care · 2025
- Study in peopleTirzepatide on ingestive behavior in adults with overweight or obesity: a randomized 6-week phase 1 trial.
Nature medicine · 2025
- Study in peopleDiet strategies for maintaining substantial therapeutic weight loss: 78-week mixed methods randomised trial.
Clinical nutrition (Edinburgh, Scotland) · 2025
- Study in peopleWeight Loss Induces Changes in Vitamin D Status in Women With Obesity But Not in Men: A Randomized Clinical Trial.
The Journal of clinical endocrinology and metabolism · 2025
- Study in peopleGenetic and physiological insights into satiation variability predict responses to obesity treatment.
Cell metabolism · 2025
- Study in peoplePhase 3 efficacy and safety trial of proposed liraglutide biosimilar for reduction of glycosylated hemoglobin (HbA1c) in patients with Type 2 diabetes mellitus.
Diabetes research and clinical practice · 2024
- Study in peopleLiraglutide enhances insulin secretion and prolongs the remission period in adults with newly diagnosed type 1 diabetes (the NewLira study): A randomized, double-blind, placebo-controlled trial.
Diabetes, obesity & metabolism · 2024
- Study in peopleEffect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial.
JAMA · 2022
- Study in peopleA phase I study comparing the pharmacokinetics of the biosimilar (RD12014) with liraglutide (Victoza) in healthy Chinese male subjects.
Clinical and translational science · 2022
- Study in peopleHealthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined.
The New England journal of medicine · 2021
- Study in peopleA Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity.
The New England journal of medicine · 2020
- Study in peopleEfficacy and safety of once-weekly semaglutide 1.0mg vs once-daily liraglutide 1.2mg as add-on to 1-3 oral antidiabetic drugs in subjects with type 2 diabetes (SUSTAIN 10).
Diabetes & metabolism · 2020
- Study in peopleLiraglutide in Children and Adolescents with Type 2 Diabetes.
The New England journal of medicine · 2019
- Study in peopleOral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomised, double-blind, phase 3a trial.
Lancet (London, England) · 2019
- Study in peopleEfficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial.
Lancet (London, England) · 2018
- Study in people3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial.
Lancet (London, England) · 2017
- Study in peopleEffect of liraglutide, a glucagon-like peptide-1 analogue, on left ventricular function in stable chronic heart failure patients with and without diabetes (LIVE)-a multicentre, double-blind, randomised, placebo-controlled trial.
European journal of heart failure · 2017
- Study in peopleLiraglutide and Renal Outcomes in Type 2 Diabetes.
The New England journal of medicine · 2017
- Study in peopleLiraglutide and Cardiovascular Outcomes in Type 2 Diabetes.
The New England journal of medicine · 2016
- Study in peopleEffects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial.
JAMA · 2016
- Study in peopleEffect of liraglutide 3.0 mg in individuals with obesity and moderate or severe obstructive sleep apnea: the SCALE Sleep Apnea randomized clinical trial.
International journal of obesity (2005) · 2016
- Study in peopleLiraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study.
Lancet (London, England) · 2016
- Study in peopleGlucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis.
Journal of hepatology · 2016
- Study in peopleA Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management.
The New England journal of medicine · 2015
- Study in peopleEfficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes: The SCALE Diabetes Randomized Clinical Trial.
JAMA · 2015
- Study in peopleEffects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults.
International journal of obesity (2005) · 2014
- Study in peopleOnce-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial.
Lancet (London, England) · 2014
- Study in peopleExenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study.
Lancet (London, England) · 2013
- Study in peopleWeight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: the SCALE Maintenance randomized study.
International journal of obesity (2005) · 2013
- Study in peopleSafety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide.
International journal of obesity (2005) · 2012
- Study in peopleLiraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial.
Lancet (London, England) · 2010
- Study in peopleLiraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial.
Lancet (London, England) · 2009
- Study in peopleLiraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial.
Diabetologia · 2009
- Study in peopleLiraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6).
Lancet (London, England) · 2009
- Study in peopleEffects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study.
Lancet (London, England) · 2009
- Study in peopleEfficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD).
Diabetes care · 2009
- Study in peopleEfficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study.
Diabetes care · 2009
- Study in peopleOne week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes.
Diabetes · 2004
- Study in peopleThe pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men.
Diabetologia · 2002
- Data from people, not a trialPatterns of Use for GLP-1 Receptor Agonists in a Weight Management Cohort: A Military Health System Database Analysis of Active Duty Service Members From 2021 to 2025.
Military medicine · 2026
- Data from people, not a trialClinical Characteristics of Users of Weight Loss Drugs: Population-Based Case-Control Study.
Diabetes, obesity & metabolism · 2026
- Data from people, not a trialCommunity Pharmacists' Knowledge and Counseling Competence on GLP-1 Receptor Agonists in Obesity and Type 2 Diabetes Care in Türkiye: A Cross-Sectional Study.
Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
- Data from people, not a trialAssessment of thyroid cancer risk associated with glucagon-like peptide 1 receptor agonist use.
Diabetes, obesity & metabolism · 2026
- Data from people, not a trialSuccessful Reversal of Tamoxifen-Associated Weight Gain and Metabolic Dysfunction with Liraglutide in a Breast Cancer Survivor: A Case Report.
Clinical medicine insights. Case reports · 2026
- Data from people, not a trialPredictors and Characteristics of Hair Loss Among Users of GLP-1 Receptor Agonists: A Cross-Sectional Analysis.
Journal of cosmetic dermatology · 2026
- Data from people, not a trialGLP-1RA Dispensing in Youth With Type 2 Diabetes: 2020 to 2023.
Pediatrics · 2026
- Data from people, not a trialWeight Loss Following Liraglutide Therapy in a Patient With Smith-Magenis Syndrome: A Case Report.
Cureus · 2026
- Data from people, not a trialTrends in glucagon-like peptide-1 receptor agonist utilization and expenditure in Croatia.
The Journal of international medical research · 2026
- Data from people, not a trialClass-Wide Disproportionate Reporting of Impaired Gastric Emptying Across Nine Glucagon-Like Peptide-1 Receptor Agonist Products: A Signal-Detection Analysis of the FDA Adverse Event Reporting System
2026
- Data from people, not a trialReal-world use of liraglutide for weight management according to label in the United Kingdom: A cohort study using the Clinical Practice Research Datalink primary care databases.
Diabetes, obesity & metabolism · 2025
- Data from people, not a trialA comparison of Glucagon-like peptide-1 receptor agonists on weight change, side effects, and quality of life in Kuwait.
Frontiers in nutrition · 2025
- Data from people, not a trialLongitudinal Analysis of Obesity Drug Use and Public Awareness.
JAMA network open · 2025
- Data from people, not a trialReal-World Use of GLP-1 Receptor Agonist Liraglutide in Adolescents with Obesity: A First Longitudinal Single-Center Analysis from Switzerland.
Children (Basel, Switzerland) · 2025
- Data from people, not a trialMortality and Serious Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists: A Pharmacovigilance Study Using the FDA Adverse Event Reporting System.
Cureus · 2024
- Data from people, not a trialReal-world persistence and adherence to glucagon-like peptide-1 receptor agonists among obese commercially insured adults without diabetes.
Journal of managed care & specialty pharmacy · 2024
- Animal study, rats or miceChanges in the Adrenal Cortex Induced by Liraglutide Treatment and Exercise in a Rat Model of Menopausal Transition.
Cells · 2026
- Animal study, rats or miceGlucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation.
Endocrinology · 2010
- Drug information page, not a studyLiraglutide
2006
- Methyl Proton Spin Relaxation (<i>R</i><sub>2</sub>/<i>R</i><sub>1</sub>) Enables Sensitive Detection of pH-Dependent Oligomerization in GLP-1 Analogs.
Analytical chemistry · 2026
- Medication Adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Diabetes care · 2026
- A comprehensive analysis of community pharmacists' practices, barriers, and strategies in patient education on Saxenda®: a qualitative study.
Journal of pharmaceutical health care and sciences · 2026
- A survey of primary care physicians' views on supporting patients who lose insurance coverage for Glucagon-Like Peptide-1-based drugs for weight management.
Obesity pillars · 2026
- Comparative analysis of IDegLira versus insulin glargine in short-term intensive therapy for overweight or obese patients with type 2 diabetes mellitus.
Endocrine · 2026
- From Prescription to Understanding: Medil AI, a Multilingual Mobile Platform for Medication Information, Pill Reminders, Adherence Support, and Between-Visit Communication
2026
- Insights from changes in NDEV biomarkers of metabolism: effects of PPARγ and GLP1 receptor agonists on brain metabolism.
The Journal of clinical endocrinology and metabolism · 2026
- RISING STARS: Effects of a GLP-1 receptor polymorphism on responses to liraglutide.
The Journal of endocrinology · 2025
- GLP-1 receptor agonists in the treatment of type 2 diabetes - state-of-the-art.
Molecular metabolism · 2021
- Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU).
Diabetic medicine : a journal of the British Diabetic Association · 2009
- No abstract available, not yet classifiedLiraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes.
Diabetes care · 2007
- Review of earlier workA Systematic Review and Meta-Analysis of Efficacy and Safety of Liraglutide in Patients with Type 2 Diabetes Mellitus.
Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
- Review of earlier workGLP-1 and GIP class drugs have neuroprotective properties in Alzheimer's and Parkinson's disease.
Frontiers in neuroscience · 2026
- Review of earlier workThe Role of GLP1 Receptor Agonists and Multi-agonist Incretin Therapies for Specific Obesity-related Health Conditions: Evidence and Rationale for Prioritisation.
Current obesity reports · 2026
- Review of earlier workGLP-1 Receptor Agonists for Weight Loss and Risk of Major Safety Outcomes: A Multicentre Cohort Study.
Diabetes, obesity & metabolism · 2026
- Review of earlier workGLP-1 Receptor Agonists and Fertility: What Is Known So Far?
JBRA assisted reproduction · 2026
- Review of earlier workGlucagon-Like Peptide-1 Receptor Agonists in Plastic Surgery: Perioperative Considerations and Safety Protocols.
Cureus · 2025
- Review of earlier workEffects of Glucagon-Like Peptide-1 receptor agonists on bone health in people living with obesity.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
- Review of earlier workAre Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists Central Nervous System (CNS) Penetrant: A Narrative Review.
Neurology and therapy · 2025
- Review of earlier workTreatment of Bile Acid Diarrhea With Glucagon-Like Peptide 1 Receptor Agonists: A Promising Yet Understudied Approach.
Clinical and translational gastroenterology · 2025
- Review of earlier workEconomic Evaluation of Medications in Prevention and Treatment of Obesity: A Systematic Review.
International journal of preventive medicine · 2025
- Review of earlier workClinical studies on anti-obesity medications in Arab countries.
Saudi medical journal · 2025
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