KPV
Animal studies onlyGet notified when the evidence changes.
Almost all the research is in animals. We do not know if the same thing happens in people.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-07-23
Also called Lysine-Proline-Valine / alpha-MSH 11-13
A three-piece fragment of a natural hormone. Studied for calming inflammation in the gut and skin.
Official status: Recommended, pending FDA rulemaking · Checked 2026-07-23
Can a doctor prescribe this?
- Small pharmacy (503A)
- An FDA panel said yes — nothing has changed yet
- Large outsourcing facility (503B)
- Never put forward to FDA
An FDA advisory panel voted 8-6 in favor in July 2026, but the rule isn't final. That usually takes a year or more.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
What FDA actually looked at
FDA reviewed this peptide for Wound healing and inflammatory conditions. That is a narrower question than the uses this peptide is usually marketed for.
What happens next
FDA has not said whether it will move KPV into Category 1 while it decides, and has not started formal rulemaking.
Without a Category 1 placement, nothing changes for pharmacies no matter how the vote went.
The July 2026 vote covered the 503A list only. No 503B review has been scheduled.
503B is the pathway that would allow large-scale supply. It has not moved.
Lab suppliers we list: 14
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Data from people, not a trialNon-contrast-enhanced magnetic resonance urography for measuring split kidney function in pediatric patients with hydronephrosis: comparison with renal scintigraphy.
Pediatric nephrology (Berlin, Germany) · 2024
- Animal study, rats or miceInflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers.
Science advances · 2026
- Animal study, rats or miceNLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development.
Cell death and differentiation · 2026
- Animal study, rats or micePepT1-targeted nanodrug based on co-assembly of anti-inflammatory peptide and immunosuppressant for combined treatment of acute and chronic DSS-induced ColitiS.
Frontiers in pharmacology · 2024
- Animal study, rats or miceVimentin is required for tumor progression and metastasis in a mouse model of non-small cell lung cancer.
Oncogene · 2023
- Animal study, rats or miceA KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon.
Acta biomaterialia · 2022
- Animal study, rats or miceBiomimetic Melanosomes Promote Orientation-Selective Delivery and Melanocyte Pigmentation in the H<sub>2</sub>O<sub>2</sub>-Induced Vitiligo Mouse Model.
ACS nano · 2021
- Animal study, rats or miceA PepT1 mediated medicinal nano-system for targeted delivery of cyclosporine A to alleviate acute severe ulcerative colitis.
Biomaterials science · 2019
- Lab dish studyKPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling.
Tissue & cell · 2026
- Lab dish studyCorrelative evaluation of anticancer effects of a modified methioninase MGL-KPV using 2D and 3D cell models, human cancer xenografts in zebrafish embryos and Balb/c nude mice
2025
- Lab dish studyKPV and RAPA Self-Assembled into Carrier-Free Nanodrugs for Vascular Calcification Therapy.
Advanced healthcare materials · 2024
- Lab test method, not a health studyA new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review.
The Journal of sports medicine and physical fitness · 2026
- Chemistry or materials paper, not a health studyStability-indicating HPLC assay for lysine-proline-valine (KPV) in aqueous solutions and skin homogenates.
Biomedical chromatography : BMC · 2015
- Lysine-proline-valine peptide attenuates hepatic lipid accumulation through ROS-dependent regulation of the PPARγ pathway in HepG2 cells.
Cytotechnology · 2026
- Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway.
Tissue & cell · 2025
- Host defense peptides as a new drug lead to a strategy for inflammatory bowel disease.
Drug discovery today · 2025
- Multicompartmental Hydrogel Microspheres with a Concentric Thin Oil Layer: Protecting and Targeting Therapeutic Agents for Inflammatory Bowel Disease.
ACS applied bio materials · 2025
- A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment.
Bioactive materials · 2024
- Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin.
Journal of pharmaceutical sciences · 2017
- Review of earlier workExploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review.
International journal of medical sciences · 2025
Spot an error? corrections@peptidesearch.org
What has happened so far
- 23 July 2026503A
FDA proposed that KPV NOT be included on the 503A Bulks List. FDA reported no human exposure data for KPV.
FDA briefing documentnot yet verified against primary source
- 23 July 2026503A
The committee voted 8-6 with one abstention to recommend KPV for the 503A Bulks List, against FDA staff's recommendation. Advisory only.
8–6, 1 abstained
Press reportnot yet verified against primary source
- 16 April 2026503A
FDA published a Federal Register notice announcing a Pharmacy Compounding Advisory Committee meeting for July 23-24, 2026 at the White Oak campus, to consider seven peptides for the 503A Bulks List.
Federal Registernot yet verified against primary source