KPV
Animal studies onlyAlmost all the research is in animals. We do not know if the same thing happens in people.
Also called Lysine-Proline-Valine / alpha-MSH 11-13
A three-piece fragment of a natural hormone. Studied for calming inflammation in the gut and skin.
Can a doctor prescribe this?
Not yet. An FDA advisory panel said it should be allowed, but the rule is not final, so pharmacies still cannot make it.
The FDA has not approved this as a medicine.
An FDA advisory panel voted 8-6 in favor in July 2026, but the rule isn't final. That usually takes a year or more.
Official status: Recommended, pending FDA rulemaking. Checked 2026-07-23.
Lab suppliers we list: 14
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
No dosing information has been published in the research indexed here.
- NLRP3 autophagic degradation disruption in melanocytes contributes to vitiligo development.
Animal study, rats or mice
Cell death and differentiation · 2026
- PepT1-targeted nanodrug based on co-assembly of anti-inflammatory peptide and immunosuppressant for combined treatment of acute and chronic DSS-induced ColitiS.
Animal study, rats or mice
Frontiers in pharmacology · 2024
- Vimentin is required for tumor progression and metastasis in a mouse model of non-small cell lung cancer.
Animal study, rats or mice
Oncogene · 2023
- A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon.
Animal study, rats or mice
Acta biomaterialia · 2022
- Biomimetic Melanosomes Promote Orientation-Selective Delivery and Melanocyte Pigmentation in the H<sub>2</sub>O<sub>2</sub>-Induced Vitiligo Mouse Model.
Animal study, rats or mice
ACS nano · 2021
- A PepT1 mediated medicinal nano-system for targeted delivery of cyclosporine A to alleviate acute severe ulcerative colitis.
Animal study, rats or mice
Biomaterials science · 2019
- Correlative evaluation of anticancer effects of a modified methioninase MGL-KPV using 2D and 3D cell models, human cancer xenografts in zebrafish embryos and Balb/c nude mice
Lab dish study
Journal not recorded · 2025
- KPV and RAPA Self-Assembled into Carrier-Free Nanodrugs for Vascular Calcification Therapy.
Lab dish study
Advanced healthcare materials · 2024
- A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review.
The Journal of sports medicine and physical fitness · 2026
- Lysine-proline-valine peptide attenuates hepatic lipid accumulation through ROS-dependent regulation of the PPARγ pathway in HepG2 cells.
Cytotechnology · 2026
- Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway.
Tissue & cell · 2025
- Host defense peptides as a new drug lead to a strategy for inflammatory bowel disease.
Drug discovery today · 2025
- Multicompartmental Hydrogel Microspheres with a Concentric Thin Oil Layer: Protecting and Targeting Therapeutic Agents for Inflammatory Bowel Disease.
ACS applied bio materials · 2025
- A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment.
Bioactive materials · 2024
- Non-contrast-enhanced magnetic resonance urography for measuring split kidney function in pediatric patients with hydronephrosis: comparison with renal scintigraphy.
Pediatric nephrology (Berlin, Germany) · 2024
- Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin.
Journal of pharmaceutical sciences · 2017
- Stability-indicating HPLC assay for lysine-proline-valine (KPV) in aqueous solutions and skin homogenates.
Biomedical chromatography : BMC · 2015
- Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers.
Review of earlier work
Science advances · 2026
- Exploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review.
Review of earlier work
International journal of medical sciences · 2025