Kisspeptin-10
Tested in peopleIt has been tested in people, but it is not an approved medicine. The studies are usually small.
Also called KP-10 / Metastin 45-54 / Kisspeptin
A natural signal that starts the hormone chain controlling reproduction. Studied in people at research centers.
Can a doctor prescribe this?
No. Pharmacies are not on record as being allowed to make this into a medicine.
The FDA has not approved this as a medicine.
Reviewed by the FDA's advisory panel in October 2024 and not recommended for the compounding list.
Official status: Not on the 503A bulks list. Checked 2024-10-29.
Lab suppliers we list: 13
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In animal studies
These are doses given to animals, usually per kilogram of body weight. They do not convert directly to a human dose.
12.5 mcg/kg
monkeys · into a vein · continuous infusion
Dynamic modulation of LH secretion by continuous kisspeptin infusion in healthy men.Hormones (Athens, Greece) · 2026
“Methods Three healthy adult men received a continuous intravenous infusion of kisspeptin-10 at a dose of 12.5 mcg/kg/h for 24 h and underwent frequent blood sampling to characterize the effect on reproductive hormones.”
40 mcg
mice ·
Kisspeptin-10 Promotes Hormone Secretion, Ovarian Follicles Development and Fecundity via PI3K/AKT/ERK Signal Pathway in Mice.Molecular reproduction and development · 2026
“For in-vivo tests, 0, 5, 10, 20, 40 μg/g of KP-10 were injected into 75 mice allocated into control group (CG) and four KP-10 treated groups (including KP-1, KP-2, KP-3, and KP-4 groups).”
25 nmol/kg
mice · another route · daily · for 21 days
Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice.Biomolecules · 2025
“We examined effects of twice-daily intraperitoneal administration of saline vehicle or kisspeptin-10 (25 nmol/kg), for 21 days, on glucose homeostasis, energy balance, circulating hormones as well as the morphology-function of enteroendocrine and islet cells in high-fat diet (HFD) fed female mice, with normal diet (ND) mice as an additional control group.”
See source wording
rats ·
Central administration of p234, kisspeptin antagonist, but not kisspeptin-10, reduces the power of epileptiform activity and slow EEG waves in male rats.Neurological research · 2025
“Methods Thirty-five male Wistar rats were divided into five groups: sham,4-AP (2.5 mg/kg i.p.), kisspeptin-10 post-treatment (200 pmoli.c.v.), p234 post-treatment (1 nmol i.c.v.), and p234 pre-treatment (1 nmol i.c.v.).”
50 nmol
mice · another route
Intraperitoneal kisspeptin-10 administration ameliorates sodium arsenite-induced reproductive toxicity in adult male mice.Andrologia · 2022
“The current study investigated the protective ameliorative effect of intraperitoneally administered kisspeptin-10 (50 nmol/day) against reproductive toxicity in adult male mice challenged with 35 days of exposure to sodium arsenite in drinking water.”
1 mcg
rats · another route · twice daily
Dose-Dependent Degeneration of Leydig Cells Following Kisspeptin-10 Administration: An Ultrastructural Study.Protein and peptide letters · 2022
“Methods We administered a range of kisspeptin-10 doses (1 μg, 1 ηg, and 10 ρg) intraperitoneally to prepubertal male Sprague-Dawley rats (PND 35) twice daily after every 12 hours.”
See source wording
mice · into a vein
Kisspeptin-10 protects against HIV-1 Tat-induced blood-brain barrier dysfunction and neuroinflammation via RhoA/ROCK pathway: Implications for HAND therapy.Neurotoxicology · 2025
“In vivo, one hour after intraperitoneal administration of 50 nmol/kg (DSS)*6-Kp-10, mice were intravenously injected with HIV-1 Tat (100 μg/kg).”
See source wording
cats ·
Role of kisspeptin-10 and betacellulin in control of feline ovarian cell functions.Reproductive biology · 2023
“For this purpose, we examined (1) the effect of the addition of BTC (0, 1, 10, and 100 ng/ml) given alone or in combination with KISS (10 ng/ml) on cultured feline ovarian fragments or granulosa cells.”
- Dynamic modulation of LH secretion by continuous kisspeptin infusion in healthy men.
Study in people
Hormones (Athens, Greece) · 2026
- CHANGES IN IRISIN RELEASE IN RESPONSE TO PERIPHERAL KISSPEPTIN-10 ADMINISTRATION IN HEALTHY AND OBESE ADULT MEN.
Study in people
Acta endocrinologica (Bucharest, Romania : 2005) · 2019
- Kisspeptin-10 Promotes Hormone Secretion, Ovarian Follicles Development and Fecundity via PI3K/AKT/ERK Signal Pathway in Mice.
Animal study, rats or mice
Molecular reproduction and development · 2026
- Dual role of Kisspeptin-10 in modulating neuroinflammation: Downregulation of NLRP3 inflammasome activation and Caspase-1-mediated pyroptosis, and activation of BAG3-dependent aggrephagy in microglial cells.
Animal study, rats or mice
Neuropeptides · 2026
- Kisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats.
Animal study, rats or mice
Acta physiologica (Oxford, England) · 2026
- Kisspeptin-10 Preserves the Blood-Brain Barrier's Integrity Post-Stroke by Augmenting Claudin-10 Expression.
Animal study, rats or mice
Clinical and experimental pharmacology & physiology · 2025
- Kisspeptin-10 Prevents the Development of Cerebral Aneurysms by Reducing the Expression of Egr-1.
Animal study, rats or mice
CNS neuroscience & therapeutics · 2025
- Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice.
Animal study, rats or mice
Biomolecules · 2025
- Kisspeptin-10 Improves Gestational Diabetes Mellitus Symptoms in Rats by Suppressing Insulin Resistance in Placental Trophoblast Cells by Activating the Cyclic AMP/Protein Kinase A Pathway.
Animal study, rats or mice
Chemical biology & drug design · 2025
- Central administration of p234, kisspeptin antagonist, but not kisspeptin-10, reduces the power of epileptiform activity and slow EEG waves in male rats.
Animal study, rats or mice
Neurological research · 2025
- The antidepressant-like effects of kisspeptin-10 are reversed by kisspeptin antagonist peptide 234 in male rats.
Animal study, rats or mice
Cellular and molecular biology (Noisy-le-Grand, France) · 2024
- Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.
Animal study, rats or mice
Nature communications · 2024
- Investigating the detection of the novel doping‐relevant peptide kisspeptin‐10 in urine using liquid chromatography high‐resolution mass spectrometry.
Animal study, rats or mice
Biomedical chromatography : BMC · 2024
- Kisspeptin-10 Improves Testicular Redox Status but Does Not Alter the Unfolded Protein Response (UPR) That Is Downregulated by Hypothyroidism in a Rat Model.
Animal study, rats or mice
International journal of molecular sciences · 2024
- Intraperitoneal administration of mouse kisspeptin-10 to mice during estrus stage induces pseudopregnancy.
Animal study, rats or mice
Genes to cells : devoted to molecular & cellular mechanisms · 2023
- What is the protective effect of preischemic kisspeptin-10 administration against ischemia/reperfusion injury of striatum on mice?
Animal study, rats or mice
Turkish journal of medical sciences · 2022
- Intraperitoneal kisspeptin-10 administration ameliorates sodium arsenite-induced reproductive toxicity in adult male mice.
Animal study, rats or mice
Andrologia · 2022
- Dose-Dependent Degeneration of Leydig Cells Following Kisspeptin-10 Administration: An Ultrastructural Study.
Animal study, rats or mice
Protein and peptide letters · 2022
- Exogenous Kisspeptin-10 inhibits ovarian cancer progression through targeting the SP1-hTERT-ZEB1 regulatory axis.
Lab dish study
Cytotechnology · 2026
- Kisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures.
Lab dish study
Pharmacological reports : PR · 2026
- Kisspeptin-10 attenuates pulmonary arterial hypertension via restoration of mitochondrial function in pulmonary artery smooth muscle cells.
Lab dish study
Neuropeptides · 2026
- Kisspeptin-10 Protects Against TNF-α-Induced Chondrocyte Senescence via the SIRT1/p53/p21 Signaling.
Lab dish study
Journal of biochemical and molecular toxicology · 2025
- Effect of neurokinin B and dynorphin A on kisspeptin-10 secretion from the anterior pituitary cells of pubescent ewes <i>in vitro</i>.
Lab dish study
Journal of veterinary research · 2025
- Kisspeptin 10 Inhibited the Proliferation, Migration, and Stemness of Esophageal Cancer Cells via Regulating the SIX1/Wnt/β-Catetin Signaling.
Lab dish study
Journal of biochemical and molecular toxicology · 2025
- Kisspeptin-10 protects against HIV-1 Tat-induced blood-brain barrier dysfunction and neuroinflammation via RhoA/ROCK pathway: Implications for HAND therapy.
Lab dish study
Neurotoxicology · 2025
- Influence of neurokinin B, dynorphin A and kisspeptin-10 on <i>in vitro</i> gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes.
Lab dish study
Journal of veterinary research · 2025
- Synthesis and characterisation of DOTA-kisspeptin-10 as a potential gallium-68/lutetium-177 pan-tumour radiopharmaceutical.
Lab dish study
Journal of neuroendocrinology · 2025
- Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity.
Lab dish study
Scientific reports · 2023
- Gametogenic and steroidogenic action of kisspeptin-10 in the Asian catfish, Clarias batrachus: Putative underlying mechanistic cascade.
Lab dish study
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2021
- Relationship between kisspeptin-10, neurokinin B and dynorphin A in the course of normal and delayed puberty in ewes.
Journal of veterinary research · 2026
- Integrated transcriptomics and miRNA-mRNA network analysis reveals Kisspeptin-10 mediated regulation of EMT and apoptosis in glioblastoma.
Computational biology and chemistry · 2026
- Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche.
Measured levels in people, no peptide given
Clinica chimica acta; international journal of clinical chemistry · 2026
- Author Correction: Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.
Nature communications · 2024
- Intraperitoneal administration of kisspeptin-10 modulates follicle maturation, gonadal steroids, calcium and metabolites in Sterlet sturgeon, Acipenser ruthenus.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2024
- Role of kisspeptin-10 and betacellulin in control of feline ovarian cell functions.
Reproductive biology · 2023
- Kisspeptin-10 and gonadotropin inhibiting hormone during pregnancy in dairy cows.
Veterinaria italiana · 2022
- Provocative tests with Kisspeptin-10 and GnRH set the scene for determining social status and environmental impacts on reproductive capacity in male African lions (Panthera leo).
General and comparative endocrinology · 2022
- Kisspeptin-10 in cryodiluent improves the post-thaw quality of Nili-Ravi buffalo (Bubalus bubalis) bull spermatozoa.
Andrologia · 2022
- Effects of kisspeptin-10 on the reproductive performance of sows in a fixed-time artificial insemination programme.
Animal : an international journal of animal bioscience · 2022
- Kisspeptin-10 Promotes Progesterone Synthesis in Bovine Ovarian Granulosa Cells via Downregulation of microRNA-1246.
Genes · 2022
- Level of kisspeptin-10 in patients with multiple sclerosis and the association between third ventricle diameter size and vitamin D level.
Measured levels in people, no peptide given
Physiology international · 2021
- Kisspeptin-10 Maintains the Activation of the mTOR Signaling Pathway by Inhibiting SIRT6 to Promote the Synthesis of Milk in Bovine Mammary Epithelial Cells.
Journal of agricultural and food chemistry · 2021
- Maternal plasma kisspeptin-10 level in preeclamptic pregnant women and its relation in changing their reproductive hormones.
Measured levels in people, no peptide given
The journal of obstetrics and gynaecology research · 2020
- The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.
Review of earlier work
Molecular and cellular endocrinology · 2026
- The KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia.
Review of earlier work
International journal of molecular sciences · 2026
- Exogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer.
Review of earlier work
Scientific reports · 2025
- Kisspeptin-10 Mitigates α-Synuclein-Mediated Mitochondrial Apoptosis in SH-SY5Y-Derived Neurons via a Kisspeptin Receptor-Independent Manner.
Review of earlier work
International journal of molecular sciences · 2023
- Kisspeptin-10 Rescues Cholinergic Differentiated SHSY-5Y Cells from α-Synuclein-Induced Toxicity In Vitro.
Review of earlier work
International journal of molecular sciences · 2022