Kisspeptin-10
Tested in peopleGet notified when the evidence changes.
It has been tested in people, but it is not an approved medicine. The studies are usually small.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-05-14
Also called KP-10 / Metastin 45-54 / Kisspeptin
A natural signal that starts the hormone chain controlling reproduction. Studied in people at research centers.
Official status: 503A Category 2 – significant safety risk · Checked 2026-05-14
Can a doctor prescribe this?
- Small pharmacy (503A)
- Category 2 — FDA flagged a safety concern
- Large outsourcing facility (503B)
- Never put forward to FDA
The FDA has "Kisspeptin-10" in Category 2 of the substances put forward for small-pharmacy (503A) compounding: the group it says raises a real safety concern. Pharmacies are not allowed to make it.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 13
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
This is a sample, not the whole literature.
About 8,000 papers mentioning this compound have been published. We show a selected sample of 90 of them, not the full literature. How we choose them · count checked 2026-08-23
- Study in peopleChronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men.
European journal of endocrinology · 2026
- Study in peopleIntravenous kisspeptin 112-121 bolus does not acutely impact circulating vasopressin in humans.
Journal of neuroendocrinology · 2026
- Study in peopleDynamic modulation of LH secretion by continuous kisspeptin infusion in healthy men.
Hormones (Athens, Greece) · 2026
- Study in peopleConcentration-QTc Modeling to Support Clinical Development of Fezolinetant.
Clinical pharmacology in drug development · 2026
- Study in peopleKisspeptin Administration Stimulates Reproductive Hormones but Does Not Affect Anxiety in Humans.
The Journal of clinical endocrinology and metabolism · 2025
- Study in peopleIntranasal kisspeptin administration rapidly stimulates gonadotropin release in humans.
EBioMedicine · 2025
- Study in peopleEffect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study.
Journal of pediatric endocrinology & metabolism : JPEM · 2025
- Study in peopleSex-dependent increases in oxytocin levels in response to intravenous kisspeptin in humans.
European journal of endocrinology · 2025
- Study in peopleKisspeptin expression levels in patients with placenta previa: A randomized trial.
Medicine · 2024
- Study in peopleEndocrine profile of the kisspeptin receptor agonist MVT-602 in healthy premenopausal women with and without ovarian stimulation: results from 2 randomized, placebo-controlled clinical tricals.
Fertility and sterility · 2024
- Study in peopleOral sodium oxybate does not alter plasma kisspeptin levels in healthy male volunteers.
Journal of psychopharmacology (Oxford, England) · 2023
- Study in peopleEffects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.
JAMA network open · 2023
- Study in peopleAcute Effects of Kisspeptin Administration on Bone Metabolism in Healthy Men.
The Journal of clinical endocrinology and metabolism · 2022
- Study in peopleEffects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial.
JAMA network open · 2022
- Study in peopleThe Effects of Kisspeptin on Brain Response to Food Images and Psychometric Parameters of Appetite in Healthy Men.
The Journal of clinical endocrinology and metabolism · 2021
- Study in peopleKisspeptin and neurokinin B interactions in modulating gonadotropin secretion in women with polycystic ovary syndrome.
Human reproduction (Oxford, England) · 2020
- Study in peopleKisspeptin receptor agonist has therapeutic potential for female reproductive disorders.
The Journal of clinical investigation · 2020
- Study in peopleAge-dependent changes in the reproductive axis responsiveness to kisspeptin-10 administration in healthy men.
Andrologia · 2019
- Study in peopleKisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome.
Human reproduction (Oxford, England) · 2019
- Study in peopleCHANGES IN IRISIN RELEASE IN RESPONSE TO PERIPHERAL KISSPEPTIN-10 ADMINISTRATION IN HEALTHY AND OBESE ADULT MEN.
Acta endocrinologica (Bucharest, Romania : 2005) · 2019
- Study in peopleA second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial.
Human reproduction (Oxford, England) · 2017
- Study in peopleInteractions Between Neurokinin B and Kisspeptin in Mediating Estrogen Feedback in Healthy Women.
The Journal of clinical endocrinology and metabolism · 2016
- Study in peopleTwice-daily subcutaneous injection of kisspeptin-54 does not abolish menstrual cyclicity in healthy female volunteers.
The Journal of clinical endocrinology and metabolism · 2013
- Data from people, not a trialKisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche.
Clinica chimica acta; international journal of clinical chemistry · 2027
- Data from people, not a trialGreen tea catechin EGCG could prevent obesity-related precocious puberty through NKB/NK3R signaling pathway.
The Journal of nutritional biochemistry · 2022
- Data from people, not a trialLevel of kisspeptin-10 in patients with multiple sclerosis and the association between third ventricle diameter size and vitamin D level.
Physiology international · 2021
- Data from people, not a trialUsing Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal Delay.
The Journal of clinical endocrinology and metabolism · 2020
- Data from people, not a trialMaternal plasma kisspeptin-10 level in preeclamptic pregnant women and its relation in changing their reproductive hormones.
The journal of obstetrics and gynaecology research · 2020
- Animal study, rats or micePreoptic kisspeptin-nNOS-GnRH (KiNG) neuronal network regulates LH rhythmicity through activation-inhibition in mice.
Nature communications · 2026
- Dog studyEffect of kisspeptin with or without cabergoline on the estrus cycle and reproductive hormones in female dogs.
Theriogenology · 2026
- Animal study, larger animalsEffect of post-mating TAK-683 (Kisspeptin analog) treatment on luteal morphology and function in suckling goats with lactational anestrus.
Animal reproduction science · 2026
- Animal study, larger animalsRelationship between kisspeptin-10, neurokinin B and dynorphin A in the course of normal and delayed puberty in ewes.
Journal of veterinary research · 2026
- Animal study, rats or miceKisspeptin-10 Promotes Hormone Secretion, Ovarian Follicles Development and Fecundity via PI3K/AKT/ERK Signal Pathway in Mice.
Molecular reproduction and development · 2026
- Animal study, rats or miceDual role of Kisspeptin-10 in modulating neuroinflammation: Downregulation of NLRP3 inflammasome activation and Caspase-1-mediated pyroptosis, and activation of BAG3-dependent aggrephagy in microglial cells.
Neuropeptides · 2026
- Animal study, rats or miceKisspeptin Restores Placental mTOR Signaling and Improves Glucose Homeostasis Mediators Disrupted by Maternal Hypothyroidism in Rats.
Acta physiologica (Oxford, England) · 2026
- Animal study, rats or miceKisspeptin System: A Modulator of Neuroinflammation and Behaviour in Temporal Lobe Epileptic Rats.
Molecular neurobiology · 2026
- Animal study, rats or miceStructural basis for Kisspeptin-10 selectivity toward KISS1R: computational insights.
In silico pharmacology · 2026
- Animal study, rats or miceMaternal Kisspeptin-10 Treatment Partially Rescues Fetal and Postnatal Cardiac Programming Disrupted by Maternal Hypothyroidism.
Cardiovascular toxicology · 2026
- Animal study, larger animalsActive immunization with a novel recombinant GnRH vaccine inhibits reproductive function in male goats.
Domestic animal endocrinology · 2025
- Animal study, rats or miceKisspeptin-10 Preserves the Blood-Brain Barrier's Integrity Post-Stroke by Augmenting Claudin-10 Expression.
Clinical and experimental pharmacology & physiology · 2025
- Animal study, rats or miceKisspeptin-10 Prevents the Development of Cerebral Aneurysms by Reducing the Expression of Egr-1.
CNS neuroscience & therapeutics · 2025
- Animal study, larger animalsEffect of neurokinin B and dynorphin A on kisspeptin-10 secretion from the anterior pituitary cells of pubescent ewes <i>in vitro</i>.
Journal of veterinary research · 2025
- Animal study, rats or miceKisspeptin-10 Improves Gestational Diabetes Mellitus Symptoms in Rats by Suppressing Insulin Resistance in Placental Trophoblast Cells by Activating the Cyclic AMP/Protein Kinase A Pathway.
Chemical biology & drug design · 2025
- Animal study, rats or miceCentral administration of p234, kisspeptin antagonist, but not kisspeptin-10, reduces the power of epileptiform activity and slow EEG waves in male rats.
Neurological research · 2025
- Animal study, rats or miceKisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice.
Biomolecules · 2025
- Animal study, larger animalsInfluence of neurokinin B, dynorphin A and kisspeptin-10 on <i>in vitro</i> gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes.
Journal of veterinary research · 2025
- Animal study, rats or miceThe antidepressant-like effects of kisspeptin-10 are reversed by kisspeptin antagonist peptide 234 in male rats.
Cellular and molecular biology (Noisy-le-Grand, France) · 2024
- Animal study, rats or miceKisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.
Nature communications · 2024
- Animal study, rats or miceKisspeptin-10 Improves Testicular Redox Status but Does Not Alter the Unfolded Protein Response (UPR) That Is Downregulated by Hypothyroidism in a Rat Model.
International journal of molecular sciences · 2024
- Animal study, larger animalsActive kisspeptin DNA vaccines oral immunization disrupt mRNA hormone receptors expression in ram lambs.
Animal biotechnology · 2023
- Animal study, larger animalsRole of kisspeptin-10 and betacellulin in control of feline ovarian cell functions.
Reproductive biology · 2023
- Animal study, rats or miceIntraperitoneal administration of mouse kisspeptin-10 to mice during estrus stage induces pseudopregnancy.
Genes to cells : devoted to molecular & cellular mechanisms · 2023
- Animal study, larger animalsResponse to kisspeptin and gonadotropin-releasing hormone agonist administration in Holstein-Friesian dairy heifers with positive or negative genetic merit for fertility traits.
Journal of dairy science · 2022
- Animal study, larger animalsKisspeptin-10 and gonadotropin inhibiting hormone during pregnancy in dairy cows.
Veterinaria italiana · 2022
- Animal study, rats or miceWhat is the protective effect of preischemic kisspeptin-10 administration against ischemia/reperfusion injury of striatum on mice?
Turkish journal of medical sciences · 2022
- Animal study, rats or miceIntraperitoneal kisspeptin-10 administration ameliorates sodium arsenite-induced reproductive toxicity in adult male mice.
Andrologia · 2022
- Animal study, larger animalsKisspeptin-10 Promotes Progesterone Synthesis in Bovine Ovarian Granulosa Cells via Downregulation of microRNA-1246.
Genes · 2022
- Animal study, rats or miceDose-Dependent Degeneration of Leydig Cells Following Kisspeptin-10 Administration: An Ultrastructural Study.
Protein and peptide letters · 2022
- Animal study, larger animalsEffects of kisspeptin-10 on the reproductive performance of sows in a fixed-time artificial insemination programme.
Animal : an international journal of animal bioscience · 2022
- Dog studySafety Evaluation of KP-10 (Metastin 45-54) Following once Daily Intravenous Administration for 14 Days in Dog.
International journal of toxicology · 2021
- Animal study, larger animalsKisspeptin-10 Maintains the Activation of the mTOR Signaling Pathway by Inhibiting SIRT6 to Promote the Synthesis of Milk in Bovine Mammary Epithelial Cells.
Journal of agricultural and food chemistry · 2021
- Animal study, larger animalsProfile of LH release in response to intramuscular treatment with kisspeptin in Bos indicus and Bos taurus prepubertal heifers.
Theriogenology · 2019
- Animal study, larger animalsCharacteristics of stimulation of gonadotropin secretion by kisspeptin-10 in female goats.
Animal reproduction science · 2010
- Lab dish studyExogenous Kisspeptin-10 inhibits ovarian cancer progression through targeting the SP1-hTERT-ZEB1 regulatory axis.
Cytotechnology · 2026
- Lab dish studyKisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures.
Pharmacological reports : PR · 2026
- Lab dish studyThe kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.
Molecular and cellular endocrinology · 2026
- Lab dish studyKisspeptin-10 attenuates pulmonary arterial hypertension via restoration of mitochondrial function in pulmonary artery smooth muscle cells.
Neuropeptides · 2026
- Lab dish studyKisspeptin-10 Protects Against TNF-α-Induced Chondrocyte Senescence via the SIRT1/p53/p21 Signaling.
Journal of biochemical and molecular toxicology · 2025
- Lab dish studyKisspeptin 10 Inhibited the Proliferation, Migration, and Stemness of Esophageal Cancer Cells via Regulating the SIX1/Wnt/β-Catetin Signaling.
Journal of biochemical and molecular toxicology · 2025
- Lab dish studySynthesis and characterisation of DOTA-kisspeptin-10 as a potential gallium-68/lutetium-177 pan-tumour radiopharmaceutical.
Journal of neuroendocrinology · 2025
- Lab dish studyKisspeptin-10 protects against HIV-1 Tat-induced blood-brain barrier dysfunction and neuroinflammation via RhoA/ROCK pathway: Implications for HAND therapy.
Neurotoxicology · 2025
- Lab dish studyKisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity.
Scientific reports · 2023
- Lab dish study[Effects of electroacupuncture on pregnancy outcome in poor ovarian response patients of kidney essence deficiency and undergoing in vitro fertilization-embryo transfer].
Zhen ci yan jiu = Acupuncture research · 2023
- Lab dish studyGametogenic and steroidogenic action of kisspeptin-10 in the Asian catfish, Clarias batrachus: Putative underlying mechanistic cascade.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2021
- Lab test method, not a health studyAnalysis and Characterization of Kisspeptin and Its Analogues in Serum and Urine Samples by Liquid Chromatography-High-Resolution Mass Spectrometry for Doping Control Purposes.
Drug testing and analysis · 2026
- Lab test method, not a health studyInvestigating the detection of the novel doping‐relevant peptide kisspeptin‐10 in urine using liquid chromatography high‐resolution mass spectrometry.
Biomedical chromatography : BMC · 2024
- Integrated transcriptomics and miRNA-mRNA network analysis reveals Kisspeptin-10 mediated regulation of EMT and apoptosis in glioblastoma.
Computational biology and chemistry · 2026
- Intraperitoneal administration of kisspeptin-10 modulates follicle maturation, gonadal steroids, calcium and metabolites in Sterlet sturgeon, Acipenser ruthenus.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2024
- No abstract available, not yet classifiedAuthor Correction: Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.
Nature communications · 2024
- Endocrine and ovarian responses to combined estradiol benzoate-sulpiride in seasonally anovulatory mares treated with kisspeptin.
Animal reproduction science · 2022
- Provocative tests with Kisspeptin-10 and GnRH set the scene for determining social status and environmental impacts on reproductive capacity in male African lions (Panthera leo).
General and comparative endocrinology · 2022
- Kisspeptin-10 in cryodiluent improves the post-thaw quality of Nili-Ravi buffalo (Bubalus bubalis) bull spermatozoa.
Andrologia · 2022
- Reproductive, antioxidant and metabolic responses of Ossimi rams to kisspeptin.
Theriogenology · 2020
- Exploring the pathophysiology of hypogonadism in men with type 2 diabetes: kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism.
Clinical endocrinology · 2013
- Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.
The Journal of clinical endocrinology and metabolism · 2011
- Review of earlier workThe KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia.
International journal of molecular sciences · 2026
- Review of earlier workEmerging peptide and neuroendocrine strategies for TRT-induced reproductive suppression and functional male hypogonadism: a narrative review.
Frontiers in reproductive health · 2026
- Review of earlier workExogenous kisspeptin-10 treatment shows pleiotropy via induction of KISS1 expression, metastasis suppression, and promotes apoptosis in triple-negative breast cancer.
Scientific reports · 2025
- Review of earlier workKisspeptin-10 Mitigates α-Synuclein-Mediated Mitochondrial Apoptosis in SH-SY5Y-Derived Neurons via a Kisspeptin Receptor-Independent Manner.
International journal of molecular sciences · 2023
- Review of earlier workKisspeptin-10 Rescues Cholinergic Differentiated SHSY-5Y Cells from α-Synuclein-Induced Toxicity In Vitro.
International journal of molecular sciences · 2022
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What has happened so far
- 14 May 2026503A
FDA lists "Kisspeptin-10" under 503A Category 2: Bulk Drug Substances that Raise Significant Safety Risks. Read from the FDA 503A category document headed "Updated May 14, 2026".