Ipamorelin
Very early researchThe research is at the earliest stage – mostly cells in a lab dish. It is far too early to say much.
Also called NNC 26-0161 / Growth hormone secretagogue
A lab-made peptide studied for raising the body's own growth hormone. Research stalled early and there is no approved use.
The basics
- What is it?
- A lab-made peptide that nudges the body to release its own growth hormone.
- What do we know?
- In early tests it does raise growth hormone in the blood, without much effect on other hormones.
- What do we still not know?
- Whether raising growth hormone this way changes anything people care about. Development was dropped years ago.
Can a doctor prescribe this?
No. Pharmacies are not on record as being allowed to make this into a medicine.
The FDA has not approved this as a medicine.
Not FDA approved and not on the 503A bulks list, so there is no legal compounding pathway.
Official status: Not on the 503A bulks list. Checked 2026-06-12.
Lab suppliers we list: 16
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In human trials
See source wording
into a vein
Safety and Efficacy of Ipamorelin Compared to Placebo for the Recovery of Gastrointestinal FunctionPHASE2 · NCT01280344
“0.03 mg/kg BID.”
In animal studies
See source wording
rats · by mouth
Design, Biological Characterization, and Discovery of Capromorelin Derivatives as Oral Growth Hormone Secretagogue Receptor Type 1a Agonist for the Treatment of Growth Hormone Deficiency.Journal of medicinal chemistry · 2025
“Starting from capromorelin, we designed, synthesized, and characterized a novel orally active GHSR-1a agonist, compound 4b (hGHSR-1a EC 50 = 0.49 nM), which effectively stimulates endogenous GH release in rats at oral doses as low as 0.1 mg/kg─100-fold more potent than ibutamoren (10 mg/kg).”
See source wording
fish · by mouth
“Experimental diets containing sAG (ranging from 0.001 to 13.04 µg/g) were prepared and fed to carp at 2.0 % of body weight (BW) in single-shot trials.”
1280 mcg/kg
mice · under the skin
Novel insights into the effects of JMV2894, a growth hormone secretagogue, in Duchenne muscular dystrophy: A preclinical study in the D2-mdx mouse model.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
“JMV2894 was administered subcutaneously at 640 or 1280 µg/kg for six weeks to 4-week-old D2-mdx mice, showing good tolerability.”
- Activation of the nucleus nuclear factor erythroid 2-related factor 2ghrelin/growth hormone secretagogue receptor 1a signaling by Yueju pill confers cardioprotective and antidepressant effects.
Animal study, rats or mice
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026
- Striosomal ghrelin receptor activity controls reward-cost integration
Animal study, rats or mice
Journal not recorded · 2026
- Sleeve Gastrectomy Is Associated with Improved Systemic Redox Homeostasis in T2DM Through Ghrelin-GHSR Attenuation, POMC Neuronal Modulation, and CD4<sup>+</sup> T Cell Metabolic Reprogramming.
Animal study, rats or mice
Antioxidants & redox signaling · 2026
- The Ghrelin/GHSR-1a Axis Attenuates Preeclampsia-like Features with Decidual Macrophage Reprogramming and Improved Placental Remodeling.
Animal study, rats or mice
Biomolecules · 2026
- Ghrelin-induced food intake in male mice requires peripheral extrahepatic GHR signaling.
Animal study, rats or mice
Endocrinology · 2026
- The endogenous ghrelin antagonist, LEAP2, accelerates puberty onset in conditions of early obesity.
Animal study, rats or mice
Metabolism: clinical and experimental · 2026
- Age-related shifts in ghrelin responsiveness of dorsomedial and ventromedial hypothalamic neurons in rats.
Animal study, rats or mice
Brain research · 2026
- Additive effect of leptin and palm-LEAP2(1-14) ameliorates obesity-induced metabolic stress in ob/ob mice.
Animal study, rats or mice
European journal of pharmacology · 2026
- Liraglutide induces enhanced suppression of food intake in mice lacking the growth hormone secretagogue receptor.
Animal study, rats or mice
Molecular and cellular endocrinology · 2025
- Design, Biological Characterization, and Discovery of Capromorelin Derivatives as Oral Growth Hormone Secretagogue Receptor Type 1a Agonist for the Treatment of Growth Hormone Deficiency.
Animal study, rats or mice
Journal of medicinal chemistry · 2025
- Ghrelin attenuates skeletal-muscle atrophy by regulating muscle protein degradation and lung inflammation in aged male mice with lipopolysaccharide-induced lung injury.
Lab dish study
Peptides · 2026
- Ghrelin's modulation of growth hormone secretagogue receptors in primary glioblastoma and meningioma: A comprehensive in-vitro study.
Lab dish study
Biochemical and biophysical research communications · 2025
- A Secondary, Subgroup Analysis of Alcohol Cue-Exposure Craving in Response to Pharmacological Inhibition of the Growth Hormone Secretagogue Receptor With PF-5190457.
Alcohol, clinical & experimental research · 2026
- Knowing the minimal detectable dose can facilitate the interpretation of a hair test result: II. Case example with ibutamoren (MK-677), a growth hormone secretagogue.
Clinica chimica acta; international journal of clinical chemistry · 2026
- Evaluation of Research Grade Peptides Marketed Directly to Consumers Reveals Extensive Variability in Purity and Measured Abundance
Journal not recorded · 2026
- Hexarelin promotes the survival of retinal ganglion cells after optic nerve transection.
Indian journal of pharmacology · 2026
- A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review.
The Journal of sports medicine and physical fitness · 2026
- GHSR-Targeted PET Imaging Probe.
ACS medicinal chemistry letters · 2026
- Oral salmon acylated ghrelin increases food intake in common carp (Cyprinus carpio) via ghrelin receptors, likely through sensory nerves rather than systemic absorption.
Peptides · 2026
- Rare variant in intracellular loop-2 alters the spatial distribution and transducer coupling selectivity of the ghrelin receptor.
Molecular pharmacology · 2026
- Molecular recognition of two approved drugs Macimorelin and Anamorelin by the growth hormone secretagogue receptor.
Acta pharmacologica Sinica · 2025
- Immunolocalization and immunoexpression levels of sibling peptides nesfatin-1 and ghrelin, and their potentially shared receptor in the gastrointestinal tract of Holstein-Friesian bulls.
Polish journal of veterinary sciences · 2025
- The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism.
Physiology & behavior · 2024
- Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.
Review of earlier work
Frontiers in aging · 2026
- Norisoboldine inhibits endoplasmic reticulum stress and alleviates depressive behaviors in CUMS mice by activating growth hormone secretagogue receptor type 1a in the hippocampus.
Review of earlier work
European journal of pharmacology · 2026
- Spontaneous Splenic Rupture in a Patient With Recent Use of Performance-Enhancing Compounds: A Case Report and Literature Review.
Review of earlier work
Cureus · 2026
- The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
Review of earlier work
Frontiers in endocrinology · 2026
- Neurobiological mechanisms of second-generation antipsychotic-induced obesity: Interactions between ghrelin signaling and neurotransmitter systems.
Review of earlier work
Brain research bulletin · 2026
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
Review of earlier work
Sports medicine (Auckland, N.Z.) · 2026
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
Review of earlier work
Journal not recorded · 2026
- Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.
Review of earlier work
The American journal of sports medicine · 2026
- Injectable Peptides in Sports Medicine: A Structured Narrative Review of Evidence, Safety, and Antidoping Implications.
Review of earlier work
JBJS reviews · 2026
- Ghrelin as a candidate molecule in translational pharmacology: Physiopharmacological actions, therapeutic pros and cons, and delivery challenges.
Review of earlier work
Toxicology and applied pharmacology · 2026
- Targeting GHSR-1α with silibinin to enhance mitophagy and prevent tubular injury in diabetic kidney disease.
Review of earlier work
Biochimica et biophysica acta. Molecular basis of disease · 2026
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Review of earlier work
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
- Dopamine D2 Receptor Isoform Heteroreceptor Complexes with the Growth Hormone Secretagogue Receptor 1a Reveals Isoform-Specific Interaction Interface Dynamics.
Review of earlier work
Journal of chemical information and modeling · 2026
- LEAP2 as a therapeutic target in obesity and cardiometabolic disorders.
Review of earlier work
Reviews in endocrine & metabolic disorders · 2026
- Edinger-Westphal Neurons Contribute to Emergence from Desflurane and Sevoflurane Anesthesia in Mice.
Review of earlier work
The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
- Novel insights into the effects of JMV2894, a growth hormone secretagogue, in Duchenne muscular dystrophy: A preclinical study in the D2-mdx mouse model.
Review of earlier work
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance
Review of earlier work
Journal not recorded · 2025
- Beyond Hunger: Structure, Signaling and Systemic Roles of Ghrelin
Review of earlier work
Journal not recorded · 2025