IGF-1 LR3
Animal studies onlyGet notified when the evidence changes.
Almost all the research is in animals. We do not know if the same thing happens in people.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-08-04
Also called Long R3 IGF-1 / Insulin-like Growth Factor 1 Long R3
A modified growth factor that lasts longer in the body. Sold mainly as a cell-culture reagent.
Official status: Not nominated for 503A compounding · Checked 2026-08-04
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Not approved and not on the compounding list. Widely sold as a laboratory reagent.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 12
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Animal study, rats or miceRevolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration.
International journal of biological macromolecules · 2025
- Animal study, larger animalsIGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.
American journal of physiology. Endocrinology and metabolism · 2025
- Animal study, larger animalsAttenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.
Journal of developmental origins of health and disease · 2023
- Animal study, larger animalsReduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.
American journal of physiology. Endocrinology and metabolism · 2021
- Animal study, larger animalsCoronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
- Animal study, larger animalsExtracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes.
American journal of physiology. Regulatory, integrative and comparative physiology · 2003
- Lab dish studyIGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype.
The American journal of pathology · 2011
- Lab dish studyNovel insulin-like growth factor-methotrexate covalent conjugate inhibits tumor growth in vivo at lower dosage than methotrexate alone.
Translational research : the journal of laboratory and clinical medicine · 2009
- Studied in plants, bacteria or fungi, not animalsRecombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris.
Applied microbiology and biotechnology · 2023
- Review of earlier workThe emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
Frontiers in endocrinology · 2026
- Review of earlier workN-Linked Glycosylation in Chinese Hamster Ovary Cells Is Critical for Insulin-like Growth Factor 1 Signaling.
International journal of molecular sciences · 2022
Spot an error? corrections@peptidesearch.org