IGF-1 LR3
Animal studies onlyAlmost all the research is in animals. We do not know if the same thing happens in people.
Also called Long R3 IGF-1 / Insulin-like Growth Factor 1 Long R3
A modified growth factor that lasts longer in the body. Sold mainly as a cell-culture reagent.
Can a doctor prescribe this?
No. Pharmacies are not on record as being allowed to make this into a medicine.
The FDA has not approved this as a medicine.
Not approved and not on the compounding list. Widely sold as a laboratory reagent.
Official status: Not on the 503A bulks list. Checked 2026-08-04.
Lab suppliers we list: 12
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In animal studies
These are doses given to animals, usually per kilogram of body weight. They do not convert directly to a human dose.
See source wording
sheep · into a vein
IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.American journal of physiology. Endocrinology and metabolism · 2025
“We previously demonstrated that a 1-wk infusion of IGF-1 LR3, an IGF-1 analog with low affinity for IGF-binding proteins and high affinity for the IGF-1 receptor, at 6.6 µg·kg -1 ·h -1 into normal fetal sheep increased body weight but lowered insulin concentrations and GSIS.”
- Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration.
Animal study, rats or mice
International journal of biological macromolecules · 2025
- Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.
Lab dish study
Journal of developmental origins of health and disease · 2023
- Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.
Lab dish study
American journal of physiology. Endocrinology and metabolism · 2021
- IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype.
Lab dish study
The American journal of pathology · 2011
- Novel insulin-like growth factor-methotrexate covalent conjugate inhibits tumor growth in vivo at lower dosage than methotrexate alone.
Lab dish study
Translational research : the journal of laboratory and clinical medicine · 2009
- Extracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes.
Lab dish study
American journal of physiology. Regulatory, integrative and comparative physiology · 2003
- IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.
American journal of physiology. Endocrinology and metabolism · 2025
- Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris.
Applied microbiology and biotechnology · 2023
- Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
- The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
Review of earlier work
Frontiers in endocrinology · 2026
- N-Linked Glycosylation in Chinese Hamster Ovary Cells Is Critical for Insulin-like Growth Factor 1 Signaling.
Review of earlier work
International journal of molecular sciences · 2022