Humanin

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into a vein

Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal TransplantationNA · NCT07678073

“Anesthesia induction will include preoxygenation with 100% oxygen for 3-5 minutes, followed by intravenous propofol (1.5-2.5 mg/kg), fentanyl (1-2 µg/kg), and rocuronium bromide (0.6 mg/kg).”

2.08 nmol

IVF Outcome in Polycystic Ovary Syndrome PatientsNot stated · NCT04104958

“clinical and/or biochemical signs of hyperandrogenism (\> 2.08 nmol/l), 3.”

2 mg/kg

rats ·

Renoprotective Effect of S14G-Humanin on Renal Ischemia/Reperfusion Injury by Activation of STAT3 and ERK 1/2 Signal Transduction Pathways in RatsJournal not recorded · 2026

“Humanin G (HNG) (2 mg/kg, iv) was administered 10 minutes before reperfusion.”

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rats · another route · twice a week

Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons RatsJournal not recorded · 2026

“Starting at postnatal day 21, RCS rats received twice a week intraperitoneal injection of either Low Dose HNG (0.4 mg/kg), High Dose HNG (4mg/kg), or sham-saline for 1 or 4 weeks.”

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rats · another route · twice a week

Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons RatsJournal not recorded · 2026

“Starting at postnatal day 21 (p21), RCS rats received twice a week intraperitoneal injections of either Low Dose HNG (0.4 mg/kg), High Dose HNG (4mg/kg), or sham-saline for 1 or 4 weeks.”

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mice · another route · for 15 days

Humanin ameliorates diabetes-induced testicular damage in a streptozotocin-induced mouse model.Experimental physiology · 2026

“Diabetes was induced via intraperitoneal administration of STZ (150 mg/kg).”

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rats · another route · twice a week

Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats.Scientific reports · 2026

“Starting at postnatal day 21, RCS rats received twice a week intraperitoneal injection of either Low Dose HNG (0.4 mg/kg), High Dose HNG (4 mg/kg), or sham-saline for 1 or 4 weeks.”

4 mg/kg

mice · daily

Repeated Humanin Treatment Attenuates Oxidative Stress, Inflammation, and Apoptosis in Diabetic Cardiac Tissue.Biology · 2026

“HN (4 mg/kg) was administered daily for 15 consecutive days.”

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rats · under the skin

Humanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats.Reproductive biology · 2026

“In Phase 1, fifty rats were randomized into control, sham, paroxetine (20 mg/kg/day via oral gavage), humanin (1 mg/kg/day via subcutaneous infusion), and paroxetine + humanin groups (n = 10/group) to evaluate sexual behavior, sperm quality, serum hormones, and dopaminergic activity within the nucleus accumbens (NAc) and medial preoptic area (MPOA).”

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mice ·

S14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis.European journal of pharmacology · 2026

“S14G-humanin (HNG), a potent analog of humanin, exerts protective effects in various diseases, but its role in DN remains unexplored.”

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mice · another route

Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice.Metabolites · 2026

“Materials and Methods : Forty male mice were randomly assigned to four groups ( n = 10 for each group): control, HN (4 mg/kg/day), STZ (150 mg/kg), and STZ + HN.”

35 mg/kg

rats ·

Potential Role of High-Intensity Interval Training-Induced Increase in Humanin Levels for the Management of Type 2 Diabetes.Journal of cellular and molecular medicine · 2025

“After diabetes induction (2-month high-fat diet and injection of 35 mg/kg streptozotocin), the animals in the EX and T2D + EX groups underwent an 8-week HIIT protocol (4-10, interval of 80%-100% of maximum speed).”

14 G

mice ·

S14G-Humanin ameliorates ovarian dysfunction in a cyclophosphamide-induced premature ovarian insufficiency mouse model.Molecular human reproduction · 2025

“S14G-Humanin (HNG), a potent analogue of Humanin, exhibits strong antioxidant and anti-apoptotic properties and has demonstrated cytoprotective effects in various tissues, including the ovary.”

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rats · another route

The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.Human reproduction (Oxford, England) · 2023

“S14G-humanin (HNG) is an HNG that has been reported to have a protective effect against myocardial fibrosis.”