Humanin
Very early researchGet notified when the evidence changes.
The research is at the earliest stage – mostly cells in a lab dish. It is far too early to say much.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-08-04
Also called HN / Rattin
Made by mitochondria and studied for protecting cells. Research is early — mostly cells and mice.
Official status: Not nominated for 503A compounding · Checked 2026-08-04
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Not approved and not on the compounding list.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 5
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
This is a sample, not the whole literature.
About 117,000 papers mentioning this compound have been published. We show a selected sample of 54 of them, not the full literature. How we choose them · count checked 2026-08-23
- Study in peoplePreserving brain health in aging: structural and biochemical benefits of water based resistance training, a randomized controlled trial.
BMC geriatrics · 2026
- Study in peopleRedox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes.
Scientific reports · 2025
- Data from people, not a trial[Effects of cardiac rehabilitation and predictive value of Humanin/CRP ratio in patients with acute exacerbation of chronic heart failure].
Zhonghua xin xue guan bing za zhi · 2026
- Data from people, not a trialAltered placental expression of small humanin-like peptides in gestational diabetes mellitus.
Upsala journal of medical sciences · 2026
- Data from people, not a trialCirculating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients.
Cardiorenal medicine · 2026
- Data from people, not a trialCirculating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy.
Experimental physiology · 2026
- Data from people, not a trialDihydroquercetin alleviates mitochondrial dysfunction and inhibits NLRP3-mediated pyroptosis in primary hepatocytes from chronic liver failure patients.
American journal of translational research · 2026
- Animal study, rats or miceRenoprotective Effect of S14G-Humanin on Renal Ischemia/Reperfusion Injury by Activation of STAT3 and ERK 1/2 Signal Transduction Pathways in Rats
2026
- Animal study, rats or miceHumanin ameliorates diabetes-induced testicular damage in a streptozotocin-induced mouse model.
Experimental physiology · 2026
- Animal study, larger animalsHumanin as a Molecular Indicator of Semen Quality and Cryotolerance in Crossbred Cattle.
Reproduction in domestic animals = Zuchthygiene · 2026
- Animal study, rats or miceHumanin analogue promotes metabolic reprogramming to protect the ischemic heart
2026
- Animal study, rats or miceNeuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats.
Scientific reports · 2026
- Animal study, rats or miceRepeated Humanin Treatment Attenuates Oxidative Stress, Inflammation, and Apoptosis in Diabetic Cardiac Tissue.
Biology · 2026
- Animal study, rats or miceHumanin peptide ameliorates reproductive dysfunction and restores neuroendocrine mechanisms in SSRI-treated male rats.
Reproductive biology · 2026
- Animal study, rats or miceHumanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction.
Biomedicines · 2026
- Animal study, rats or miceS14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis.
European journal of pharmacology · 2026
- Animal study, rats or miceHumanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy.
Biochemistry and biophysics reports · 2026
- Animal study, rats or miceHumanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice.
Metabolites · 2026
- Animal study, rats or miceS14G-humanin attenuates renal ischaemia-reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats.
Experimental physiology · 2026
- Animal study, rats or miceS14G-Humanin ameliorates ovarian dysfunction in a cyclophosphamide-induced premature ovarian insufficiency mouse model.
Molecular human reproduction · 2025
- Animal study, rats or miceOligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis.
Andrology · 2025
- Animal study, rats or miceHepatic and Pancreatic Cellular Response to Early Life Nutritional Mismatch.
Endocrinology · 2025
- Animal study, rats or miceHumanin alone and in combination with GnRHa therapy attenuates ovarian dysfunction induced by prepubertal cyclophosphamide chemotherapy in female mice.
Reproductive toxicology (Elmsford, N.Y.) · 2025
- Animal study, rats or miceMyeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling.
Cell reports. Medicine · 2024
- Animal study, rats or miceThe humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.
Human reproduction (Oxford, England) · 2023
- Lab dish studyHumanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells.
American journal of respiratory cell and molecular biology · 2026
- Lab dish studyNetwork Topology and Interactomic Analysis Reveal the Regulatory Framework of the Humanin Protein Family (MTRNR2Lx Class).
Biomolecules · 2026
- Lab dish studyMitochondrial-derived peptide Humanin protects granulosa cells under oxidative conditions.
Reproduction (Cambridge, England) · 2026
- Lab dish studyHumanin reduces nucleus pulposus cells ferroptosis to alleviate intervertebral disc degeneration: An in vitro and in vivo study.
Journal of orthopaedic translation · 2025
- Lab dish studyAmeliorative effects of Gly[14]-humanin on cyclophosphamide-induced premature ovarian insufficiency and underlying mechanisms.
Reproductive biomedicine online · 2025
- Lab dish studyHUMANIN produced by human efferocytic macrophages promotes the resolution of inflammation.
Cell death & disease · 2025
- Lab dish studyHumanin variants aggregate to produce different fibril morphologies.
The Journal of biological chemistry · 2025
- Hypothesis, not a tested studyHumanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway.
Toxicology and industrial health · 2026
- Hypothesis, not a tested studyMediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE; potential role of the Humanin-Nox2 interaction in cardioprotection.
Frontiers in nutrition · 2025
- Hypothesis, not a tested studyPotential Role of High-Intensity Interval Training-Induced Increase in Humanin Levels for the Management of Type 2 Diabetes.
Journal of cellular and molecular medicine · 2025
- Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.
Physiological reports · 2026
- No abstract available, not yet classifiedMitochondrial-derived Peptides and Cytoprotection in ARDS: Emerging Therapeutic Promise of Humanin.
American journal of respiratory cell and molecular biology · 2026
- Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull.
Scientific reports · 2026
- Humanin Mitigates Aβ-Induced Retinal Pigment Epithelium Injury via AMPK-Beclin1-Dependent Mitophagy.
Aging cell · 2026
- Low Dose Ketamine Preconditions Astrocyte Mitochondria to Achieve Antidepressant Efficacy via Adenosine, Humanin, and Melatonin Upregulation and Efflux.
Alpha psychiatry · 2026
- AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition.
Antioxidants (Basel, Switzerland) · 2026
- Enduring Effects of Humanin on Mitochondrial Systems in TBI Pathology.
Biomolecules · 2025
- Mitochondrial-derived peptides, HNG and SHLP3, protect cochlear hair cells against gentamicin.
Cell death discovery · 2024
- [Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6.
Scientific reports · 2024
- Exogenous humanin and MOTS-c function as protective agents against gentamicin-induced hair cell damage.
Biochemical and biophysical research communications · 2023
- Review of earlier workMitochondrial-Derived Peptides as Therapeutics and Biomarkers for Combating Vascular Aging and Associated Cardiovascular Diseases.
Current cardiology reviews · 2026
- Review of earlier workMitochondria-derived peptides in liver disease: Emerging regulators of hepatic metabolism and therapeutic targets.
Hepatology communications · 2026
- Review of earlier workHumanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity.
Free radical biology & medicine · 2026
- Review of earlier workThe MTRNR2L gene family and age-related macular degeneration.
Frontiers in immunology · 2026
- Review of earlier workA Review on the Potential Role of Humanin Peptide and its Analogs in the Regulation of Autophagy Pathways for Therapeutic Application in Metabolic Disorders.
Protein and peptide letters · 2025
- Review of earlier workThe neuroprotective role of Humanin in Alzheimer's disease: The molecular effects.
European journal of pharmacology · 2025
- Review of earlier workInterlaced roles of mitochondrial DNA in colorectal cancer: Liquid-biopsy biomarkers, nuclear mtDNA-driven genomic instability, and mito-encoded micro peptide signaling.
World journal of gastrointestinal oncology · 2025
- Review of earlier workInsights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.
International journal of molecular sciences · 2025
- Review of earlier workNeuroprotective Action of Humanin and Humanin Analogues: Research Findings and Perspectives.
Biology · 2023
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