HNG
Animal studies onlyGet notified when the evidence changes.
Almost all the research is in animals. We do not know if the same thing happens in people.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-08-04
Also called Humanin G / S14G-Humanin
A lab-altered version of Humanin, studied in animals for metabolism and brain protection.
The basics
- What is it?
- HNG is Humanin with one amino acid swapped (serine 14 to glycine), which makes it more active in animal studies. It is a variant of Humanin — see the Humanin page for the natural form.
Official status: Not nominated for 503A compounding · Checked 2026-08-04
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Not FDA approved and not on the U.S. compounding list. A doctor cannot prescribe it.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 2
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Study in peopleMass balance, excretion, and pharmacokinetics of a single oral dose of [<sup>14</sup>C]pixavir marboxil in healthy Chinese male participants.
Frontiers in pharmacology · 2026
- Study in peopleInteraction between midazolam and clarithromycin: comparison with azithromycin.
International journal of clinical pharmacology and therapeutics · 1996
- Animal study, rats or miceS14G-humanin (HNG) ameliorates diabetic nephropathy tubular injury by inhibiting Z-DNA/ZBP1-mediated necroptosis.
European journal of pharmacology · 2026
- Animal study, rats or miceNeuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats.
Scientific reports · 2026
- Animal study, rats or miceHumanin analogue promotes metabolic reprogramming to protect the ischemic heart
2026
- Animal study, rats or miceHumanin improves bone health in a glucocorticoid-treated mouse model of Duchenne muscular dystrophy.
Biochemistry and biophysics reports · 2026
- Animal study, rats or miceRenoprotective Effect of S14G-Humanin on Renal Ischemia/Reperfusion Injury by Activation of STAT3 and ERK 1/2 Signal Transduction Pathways in Rats
2026
- Animal study, rats or miceHumanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction.
Biomedicines · 2026
- Animal study, rats or miceS14G-humanin attenuates renal ischaemia-reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats.
Experimental physiology · 2026
- Animal study, rats or miceS14G-Humanin ameliorates ovarian dysfunction in a cyclophosphamide-induced premature ovarian insufficiency mouse model.
Molecular human reproduction · 2025
- Animal study, rats or miceQuantitative proteomics analysis reveals the protective role of S14G-humanin in septic acute kidney injury using 4D-label-free and PRM Approaches.
Biochemical and biophysical research communications · 2024
- Animal study, rats or miceRational fusion design inspired by cell-penetrating peptide: SS31/S-14 G Humanin hybrid peptide with amplified multimodal efficacy and bio-permeability for the treatment of Alzheimer's disease.
Asian journal of pharmaceutical sciences · 2024
- Animal study, rats or miceS14G-humanin alleviates acute lung injury by inhibiting the activation of NF-κB.
Aging · 2023
- Animal study, rats or miceThe humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.
Human reproduction (Oxford, England) · 2023
- Animal study, rats or miceS14G-Humanin ameliorates ovalbumin-induced airway inflammation in asthma mediated by inhibition of toll-like receptor 4 (TLR4) expression and the nuclear factor κ-B (NF-κB)/early growth response protein-1 (Egr-1) pathway.
Aging · 2023
- Animal study, rats or miceS14G-humanin confers cardioprotective effects against chronic adrenergic and pressure overload-induced heart failure in mice.
Heliyon · 2023
- Animal study, rats or miceEffectiveness of analog of Humanin in ameliorating streptozotocin-induced diabetic nephropathy in Sprague Dawley rats.
Peptides · 2023
- Animal study, rats or miceThe protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis.
Bioengineered · 2022
- Animal study, rats or miceThe protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction.
Bioengineered · 2021
- Lab dish studyHumanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells.
American journal of respiratory cell and molecular biology · 2026
- Lab dish studyA Fully Biodegradable Hybrid Nanogenerator with Mo Nanoparticle-Mediated Dielectric Enhancement for Improved In Vivo Energy Harvesting.
ACS applied materials & interfaces · 2026
- Lab dish studyEffects of Humanin G (HNG) on angiogenesis and neurodegeneration markers in Age-related Macular Degeneration (AMD).
Mitochondrion · 2024
- Lab dish studyHumanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage.
Cell death & disease · 2017
- High-Power Hybrid Nanogenerator With Multi-Degree-of-Freedom Mechanical Coupling for Harvesting Water Wave Energy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
- Mitochondrial-derived peptides MOTS-c and humanin attenuate dexamethasone-induced atrophy in human skeletal muscle cells.
Physiological reports · 2026
- Arsenic Promotes Intracellular Aβ<sub>(1-42)</sub> Accumulation via Enhanced APP but Reduced NEP Expression, and Indirectly Stimulates Extracellular Aβ Aggregation through AChE Induction in Differentiated SH-SY5Y Cells.
Biological trace element research · 2026
- Tunable Synthesis of Multi-Responsive NH-Containing Helical Nanographenes With a Chiroptical Switching Function.
Angewandte Chemie (International ed. in English) · 2026
- A Hybrid Nanogenerator Based on Rotational-Swinging Mechanism for Energy Harvesting and Environmental Monitoring in Intelligent Agriculture.
Sensors (Basel, Switzerland) · 2025
- Early feeding with hydrogel nutrients modifies cecal microbiota, immunity, gene expression, and improves growth performance in ostrich chicks.
Poultry science · 2025
- Stability Determination of Intact Humanin-G with Characterizations of Oxidation and Dimerization Patterns.
Biomolecules · 2023
- The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway.
Bioengineered · 2021
- S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
- The pharmacokinetics of extended-release formulations of calcium antagonists and of amlodipine in subjects with different gastrointestinal transit times.
Journal of clinical pharmacology · 1999
- Review of earlier workResearch Progress of Pyroelectric Nanogenerator and Its Hybrid Nanogenerators.
Materials (Basel, Switzerland) · 2026
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