Hexarelin

In animal studies

These are doses given to animals, usually per kilogram of body weight. They do not convert directly to a human dose.

• 200 mcg/kg

  mice · twice per day

  Hexarelin attenuates abdominal aortic aneurysm formation by inhibiting SMC phenotype switch and inflammasome activation.Microvascular research · 2022

  “The present study determined the effect of hexarelin administration (200 μg/kg twice per day) in a mouse model of elastase-induced abdominal aortic aneurysm.”

• 5 mg/mL

  rats ·

  Effect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats.Acta pharmaceutica Sinica. B · 2021

  “These luminal compositions included two paracellular permeation enhancers, chitosan (5 mg/mL) and ethylenediaminetetraacetate (EDTA, 1 and 5 mg/mL), as well as low luminal tonicity (100 mOsm) with or without lidocaine.”

• 10.56 mcg/day

  mice · into a vein · for 3-4 weeks

  Stimulation of endogenous pulsatile growth hormone secretion by activation of growth hormone secretagogue receptor reduces the fat accumulation and improves the insulin sensitivity in obese mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021

  “Male melanocortin 4 receptor knockout mice (MC4RKO) were pair-fed and received continuous hexarelin (10.56 μg/day) or vehicle infusion by an osmotic pump for 3-4 weeks.”

• See source wording

  rats ·

  Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats.Canadian journal of physiology and pharmacology · 2021

  “A total of 104 Wistar albino male adult rats (weighing approximately 220-240 g) were used in the experiments.”

• 0.3 mg/kg/day

  mice · for 21 days

  Hexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in a mouse model of myocardial ischemia-reperfusion.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020

  “Myocardial ischemia was induced by transient ligation of the left descending coronary artery (tLAD) in C57BL/6 J mice followed by HEX (0.3 mg/kg/day; n = 20) or vehicle (VEH) (n = 18) administration for 21 days, first administered immediately prior-to reperfusion.”

• 100 mcg/kg

  mice · for 3 months

  Hexarelin attenuates atherosclerosis via inhibiting LOX-1-NF-κB signaling pathway-mediated macrophage ox-LDL uptake in ApoE^-/- mice.Peptides · 2019

  “Mice were treated either with hexarelin (100 μg/kg s.c., q.d.”

• 100 mcg/kg

  rats · under the skin · twice a day · for 30 days

  Modulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in ratsTurkish journal of medical sciences · 2019

  “The rats were treated with subcutaneous injection of hexarelin (100 μg/kg) in the treatment group or saline in the other groups twice a day for 30 days.”

• See source wording

  rats · daily

  Enhanced Pulsatile Growth Hormone Secretion and Altered Metabolic Hormones by in Vivo Hexarelin Treatment in Streptozotocin-Induced Diabetic Rats.International journal of molecular sciences · 2018

  “Thus, we aim to investigate the effect of hexarelin, a synthetic GH secretagogue (GHS), on GH secretion in streptozotocin (STZ, 65 mg/kg)-induced diabetic rats.”

• See source wording

  rats · daily · for 2 weeks

  Improvement of cardiomyocyte function by in vivo hexarelin treatment in streptozotocin-induced diabetic rats.Physiological reports · 2018

  “Streptozotocin (STZ, 65 mg/kg)-induced diabetic rat model was employed with vehicle injection group as control.”

• See source wording

  rats · under the skin · twice daily · for 7 days

  The Growth Hormone Secretagogue Hexarelin Protects Rat Cardiomyocytes From in vivo Ischemia/Reperfusion Injury Through Interleukin-1 Signaling Pathway.International heart journal · 2017

  “The rats were then treated subcutaneously twice daily with hexarelin [100 μg/kg·day], ghrelin [400 μg/ kg·day], or saline for 7 days.”

• 200 mcg/kg

  mice · another route · twice daily · for 12 days

  Hexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice.Endocrinology · 2017

  “In this study, the effects of twice daily intraperitoneal injections of hexarelin (200 μg/kg body weight) were examined in nonobese insulin-resistant MKR mice and corresponding wild-type FVB mice for 12 days.”

• See source wording

  rats · by mouth

  The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin.Pharmaceutics · 2020

  “The objective of this single-pass perfusion study in rat was to investigate the effect of SDS at 5 mg/mL and of caprate administered at different luminal concentrations (5, 10, and 20 mg/mL) and pH (6.5 and 7.4).”

• 100 mcg/kg/day

  rats · for 7 days

  Hexarelin alleviates apoptosis on ischemic acute kidney injury via MDM2/p53 pathway.European journal of medical research · 2023

  “In the I/R-induced AKI model, rats were pretreated with Hexarelin at 100 μg/kg/d for 7 days before being sacrificed 24 h post-IRI.”