Hexarelin
Tested in peopleGet notified when the evidence changes.
It has been tested in people, but it is not an approved medicine. The studies are usually small.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-08-04
Also called Examorelin / EP-23905
Studied for raising growth hormone. Also looked at for effects on the heart.
Official status: Not nominated for 503A compounding · Checked 2026-08-04
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Never approved anywhere. Not on the 503A list.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 8
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Study in peopleHexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers.
Psychoneuroendocrinology · 2004
- Study in peopleEffects of glucose, free fatty acids or arginine load on the GH-releasing activity of ghrelin in humans.
Clinical endocrinology · 2002
- Study in peopleImpact of two or three daily subcutaneous injections of hexarelin, a synthetic growth hormone (GH) secretagogue, on 24-h GH, prolactin, adrenocorticotropin and cortisol secretion in humans.
European journal of endocrinology · 2002
- Study in peopleThe effect of an opiate antagonist on the hormonal changes induced by hexarelin.
Clinical endocrinology · 1995
- Study in peopleArginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of hexarelin in elderly subjects.
The Journal of clinical endocrinology and metabolism · 1994
- Study in peopleGrowth hormone-releasing activity of hexarelin in humans. A dose-response study.
European journal of clinical pharmacology · 1994
- Data from people, not a trialEffects of cortistatin-14 and somatostatin-14 on the endocrine response to hexarelin in humans.
Journal of endocrinological investigation · 2003
- Animal study, rats or miceHistopathological and immunohistochemical characterization of MPTP-associated pancreatic injury and its attenuation by Hexarelin in mice.
Journal of molecular histology · 2026
- Animal study, rats or miceProtective and restorative effects of hexarelin on MPTP-induced lung injury in mice.
Journal of basic and clinical physiology and pharmacology · 2026
- Animal study, rats or micePharmacological targeting of the hyper-inflammatory response to SARS-CoV-2-infected K18-hACE2 mice using a cluster of differentiation 36 receptor modulator.
Frontiers in pharmacology · 2024
- Animal study, rats or miceHexarelin attenuates abdominal aortic aneurysm formation by inhibiting SMC phenotype switch and inflammasome activation.
Microvascular research · 2022
- Animal study, rats or miceUsing Synchrotron Radiation Imaging Techniques to Elucidate the Actions of Hexarelin in the Heart of Small Animal Models.
Frontiers in physiology · 2021
- Animal study, rats or miceEffect of paracellular permeation enhancers on intestinal permeability of two peptide drugs, enalaprilat and hexarelin, in rats.
Acta pharmaceutica Sinica. B · 2021
- Animal study, rats or miceStimulation of endogenous pulsatile growth hormone secretion by activation of growth hormone secretagogue receptor reduces the fat accumulation and improves the insulin sensitivity in obese mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
- Animal study, rats or miceGhrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats.
Canadian journal of physiology and pharmacology · 2021
- Animal study, rats or miceHexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in a mouse model of myocardial ischemia-reperfusion.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020
- Animal study, rats or miceHexarelin attenuates atherosclerosis via inhibiting LOX-1-NF-κB signaling pathway-mediated macrophage ox-LDL uptake in ApoE<sup>-/-</sup> mice.
Peptides · 2019
- Animal study, rats or miceModulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in rats
Turkish journal of medical sciences · 2019
- Animal study, rats or miceEnhanced Pulsatile Growth Hormone Secretion and Altered Metabolic Hormones by in Vivo Hexarelin Treatment in Streptozotocin-Induced Diabetic Rats.
International journal of molecular sciences · 2018
- Animal study, rats or miceImprovement of cardiomyocyte function by in vivo hexarelin treatment in streptozotocin-induced diabetic rats.
Physiological reports · 2018
- Animal study, rats or miceThe Growth Hormone Secretagogue Hexarelin Protects Rat Cardiomyocytes From in vivo Ischemia/Reperfusion Injury Through Interleukin-1 Signaling Pathway.
International heart journal · 2017
- Animal study, rats or miceHexarelin, a Growth Hormone Secretagogue, Improves Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice.
Endocrinology · 2017
- Animal study, rats or miceGrowth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia.
Scientific reports · 2017
- Animal study, rats or miceGrowth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia.
Journal of cachexia, sarcopenia and muscle · 2017
- Animal study, rats or miceEndocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone.
The Journal of clinical endocrinology and metabolism · 2001
- Studied in worms or fishZebrafish (Danio rerio) water tank model for the investigation of drug metabolism: Progress, outlook, and challenges.
Drug testing and analysis · 2018
- Lab dish studyProtective Effects of Hexarelin and JMV2894 in a Human Neuroblastoma Cell Line Expressing the SOD1-G93A Mutated Protein.
International journal of molecular sciences · 2023
- Lab dish studyHexarelin Modulation of MAPK and PI3K/Akt Pathways in Neuro-2A Cells Inhibits Hydrogen Peroxide-Induced Apoptotic Toxicity.
Pharmaceuticals (Basel, Switzerland) · 2021
- Lab dish studyThe In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin.
Pharmaceutics · 2020
- Lab dish studyHexarelin exerts neuroprotective and antioxidant effects against hydrogen peroxide-induced toxicity through the modulation of MAPK and PI3K/Akt patways in Neuro-2A cells
2020
- Lab test method, not a health studyIdentification of alexamorelin consumption biomarkers using human hepatocyte incubations and high-resolution mass spectrometry.
Journal of analytical toxicology · 2025
- Hypothesis, not a tested studyHexarelin protects cardiac H9C2 cells from angiotensin II-induced hypertrophy <i>via</i> the regulation of autophagy.
Die Pharmazie · 2019
- Hexarelin promotes the survival of retinal ganglion cells after optic nerve transection.
Indian journal of pharmacology · 2026
- Revealing the interaction between peptide drugs and permeation enhancers in the presence of intestinal bile salts.
Nanoscale · 2023
- No abstract available, not yet classifiedHexarelin modulates lung mechanics, inflammation, and fibrosis in acute lung injury.
Drug target insights · 2021
- SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) - A drug repurposing study.
Heliyon · 2020
- The CD36-PPARγ Pathway in Metabolic Disorders.
International journal of molecular sciences · 2018
- Age-related differences in growth hormone (GH) regulation during strenuous exercise.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2004
- GHRP-6 is able to stimulate cortisol and ACTH release in patients with Cushing's disease: comparison with DDAVP.
Journal of endocrinological investigation · 2003
- Effects of acute hexarelin administration on cardiac performance in patients with coronary artery disease during by-pass surgery.
European journal of pharmacology · 2002
- Recombinant human IGF-I does not modify the ACTH and cortisol responses to hCRH and hexarelin, a peptidyl GH secretagogue, in humans.
Journal of endocrinological investigation · 2001
- Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans.
The Journal of clinical endocrinology and metabolism · 2001
- Growth hormone-independent cardiotropic activities of growth hormone-releasing peptides in normal subjects, in patients with growth hormone deficiency, and in patients with idiopathic or ischemic dilated cardiomyopathy.
Endocrine · 2001
- Desmopressin and hexarelin tests in alcohol-induced pseudo-Cushing's syndrome.
Journal of internal medicine · 2000
- The negative GH auto-feedback in childhood: effects of rhGH and/or GHRH on the somatotroph response to GHRH or hexarelin, a peptidyl GH secretagogue, in children.
Journal of endocrinological investigation · 2000
- Role of food intake in the modulation of hexarelin-induced growth hormone release in normal human subjects.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2000
- Interaction between glucagon and hexarelin, a peptidyl GH secretagogue, on somatotroph and corticotroph secretion in humans.
European journal of endocrinology · 2000
- The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin.
The Journal of clinical endocrinology and metabolism · 1999
- Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humans.
Journal of endocrinological investigation · 1999
- Tyr-Ala-Hexarelin, a synthetic octapeptide, possesses the same endocrine activities of Hexarelin and GHRP-2 in humans.
Journal of endocrinological investigation · 1999
- The effect of chronic hexarelin administration on the pituitary-adrenal axis and prolactin.
Clinical endocrinology · 1999
- Cardiac effects of hexarelin in hypopituitary adults.
European journal of pharmacology · 1999
- Effects of alprazolam, a benzodiazepine, on the ACTH-, GH- and PRL-releasing activity of hexarelin, a synthetic peptidyl GH secretagogue (GHS), in patients with simple obesity and in patients with Cushing's disease.
Pituitary · 1999
- The effects of dose, nutrition, and age on hexarelin-induced anterior pituitary hormone secretion in adult patients on maintenance hemodialysis.
The Journal of clinical endocrinology and metabolism · 1999
- Corticotropin-releasing effect of hexarelin, a peptidyl GH secretagogue, in normal subjects pretreated with metyrapone or RU-486, a glucocorticoid receptor antagonist, and in patients with Addison's disease.
Neuroendocrinology · 1999
- Does desensitization to hexarelin occur?
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 1998
- Effects of dexamethasone and alprazolam, a benzodiazepine, on the stimulatory effect of hexarelin, a synthetic GHRP, on ACTH, cortisol and GH secretion in humans.
Neuroendocrinology · 1998
- The growth hormone response to hexarelin in patients with different hypothalamic-pituitary abnormalities.
The Journal of clinical endocrinology and metabolism · 1998
- Lack of effect of hexarelin on TRH-induced TSH response in normal adult man.
Journal of endocrinological investigation · 1998
- Growth hormone response to hexarelin, growth hormone-releasing hormone plus pyridostigmine and arginine plus estrogen in prepubertal and early pubertal short children.
Minerva endocrinologica · 1998
- Growth hormone status during long-term hexarelin therapy.
The Journal of clinical endocrinology and metabolism · 1998
- Interaction of the growth hormone releasing peptide hexarelin with somatostatin.
Clinical endocrinology · 1997
- Hexarelin, a synthetic growth-hormone releasing peptide, shows no interaction with corticotropin-releasing hormone and vasopressin on adrenocorticotropin and cortisol secretion in humans.
Neuroendocrinology · 1997
- Hexarelin is a stronger GH-releasing peptide than GHRH in normal cycling women but not in anorexia nervosa.
Journal of endocrinological investigation · 1997
- Acute administration of hexarelin stimulates GH secretion during day and night in normal men.
Clinical endocrinology · 1997
- Low hexarelin dose and pyridostigmine have additive effect and potentiate to the same extent the GHRH-induced GH response in man.
Clinical endocrinology · 1997
- Mechanisms underlying the negative growth hormone (GH) autofeedback on the GH-releasing effect of hexarelin in man.
Metabolism: clinical and experimental · 1997
- Non-parametric deconvolution provides an objective assessment of GH responsiveness to GH-releasing stimuli in normal subjects.
Clinical endocrinology · 1997
- Growth hormone release by the novel GH releasing peptide hexarelin in patients with homozygous beta-thalassemia.
Journal of pediatric endocrinology & metabolism : JPEM · 1997
- Hexarelin-induced growth hormone, cortisol, and prolactin release: a dose-response study.
The Journal of clinical endocrinology and metabolism · 1996
- The sequential administration of growth hormone-releasing hormone followed 120 minutes later by hexarelin, as an effective test to assess the pituitary GH reserve in man.
Clinical endocrinology · 1996
- The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity.
Clinical endocrinology · 1996
- Influence of beta-adrenergic agonists and antagonists on the GH-releasing effect of Hexarelin in man.
Journal of endocrinological investigation · 1996
- Hexarelin, a synthetic growth hormone releasing peptide, stimulates prolactin secretion in acromegalic but not in hyperprolactinaemic patients.
Clinical endocrinology · 1996
- Hexarelin induced growth hormone release is influenced by exogenous growth hormone.
Clinical endocrinology · 1995
- GH responsiveness to repeated GHRH or hexarelin administration in normal adults.
Journal of endocrinological investigation · 1995
- Comparison of the effects of growth hormone-releasing hormone and hexarelin, a novel growth hormone-releasing peptide-6 analog, on growth hormone secretion in humans with or without glucocorticoid excess.
The Journal of endocrinology · 1995
- Review of earlier workThe emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
Frontiers in endocrinology · 2026
- Review of earlier workHexarelin alleviates apoptosis on ischemic acute kidney injury via MDM2/p53 pathway.
European journal of medical research · 2023
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