HCG
Approved medicineThe FDA has approved a version of this as a medicine, so it has been through large studies in people.
Also called Human Chorionic Gonadotropin / Pregnyl / Ovidrel / Novarel
An approved fertility drug. Also used alongside testosterone therapy. Not approved for weight loss.
Can a doctor prescribe this?
Yes. Pharmacies are allowed to make it, so a doctor can write a prescription for it.
The FDA has approved a version of this as a medicine.
Approved for fertility uses and prescription-only. The FDA requires labeling stating it is not effective for weight loss.
Official status: On the 503A bulks list. Checked 2026-08-04.
Lab suppliers we list: 2
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In human trials
500 IU
Intrauterine Injection of Human Chorionic Gonadotrophin and Pregnancy Rate in ICSINA · NCT03445910
“intrauterine injected of 500 IU of hCG on the day of ovum pick-up and.”
150 IU/day
Non-FSH vs FSH-priming in Cycles With CAPA-IVM TreatmentNA · NCT05600972
“Patients who are randomized into the FSH priming arm will receive two days of FSH injections of 150 IU/day.”
See source wording
twice daily
Progesterone Versus Progesterone Plus Dydrogesterone in FETNA · NCT03998761
“Patients will receive micronized progesterone (Cyclogest® 400mg; Actavis) at the dose of 400mg twice daily (morning and evening).”
150 IU
daily
Severe LH Suppressed Patients After Administration of a GnRH AntagonistPHASE4 · NCT01936077
“150 IU recombinant LH daily..”
See source wording
Low Dose Human Chorionic Gonadotropin: Influence on the EndometriumPHASE4 · NCT00976651
“200 IU per day in the late follicular phase.”
See source wording
by mouth
A Method to Evaluate Glucose-Dependent Insulin Secretion in Healthy Males (MK-0431-179)PHASE1 · NCT00888238
“Single oral dose of sitagliptin 100 mg (2 x 50 mg) tablets followed by the hyperglycemic clamp procedure and meal tolerance test..”
See source wording
under the skin
“administration of r-LH 150 IU/day subcutaneously , from S1 to r-hCG administration day (treatment day 10 to 14).”
See source wording
Use of Low Dose of HCG During Ovulation Induction With CC in Women With CC Resistant PCOSPHASE4 · NCT02436226
“Women will receive clomiphene citrate (150 mg/day for 5 consecutive days from day 2 of cycle) and HCG (200 IU/day SC from day 7 of cycle).”
See source wording
daily · for 8 weeks
hCG Priming in Women With Low Ovarian ReservePHASE4 · NCT04643925
“Control cycle: A standard IVF/ICSI cycle in the fixed GnRH-antagonist protocol using a daily dose of 300 IU rFSH initiated from cd 2-3 and the GnRH antagonist (Fyremadel 0.25 mg) from stimulation day 5-6 followed by blastocyst culture and a freeze-all strategy.”
See source wording
Follicle Size and Oocyte DevelopmentNA · NCT03660813
“Ovitrelle ( Hcg 250 mcg).”
See source wording
under the skin
GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FETPHASE3 · NCT04064840
“When at least three follicles reach 18 mm in diameter, recombinant hCG 0.25mg and decapeptyl 0.2mg will be injected subcutaneously..”
See source wording
Low Dose hCG in the Late Follicular PhasePHASE4 · NCT00750100
“hCG 200IU in the late follicular phase.”
- Can β-Human Chorionic Gonadotropin in Uterine Cavity Lavage Serve as a Differential Diagnostic Tool for Pregnancies of Unknown Location? Insights from a Prospective Study.
Study in people
Gynecologic and obstetric investigation · 2026
- Human chorionic gonadotropin alpha and beta levels are associated with maternal demographic characteristics and psychosocial measures of stress and discrimination.
Study in people
Psychoneuroendocrinology · 2026
- Avelumab Plus Methotrexate for Gestational Trophoblastic Tumors: The TROPHAMET Phase 1/2 Nonrandomized Clinical Trial.
Study in people
JAMA oncology · 2026
- Trigger-day hCG effects on DNA methylation and neurodevelopment in ART offspring.
Animal study, rats or mice
Nature communications · 2026
- Predicting in vitro fertilization success: establishing human chorionic gonadotropin cutoffs after frozen embryo transfers for untested and preimplantation genetic tested embryos.
Lab dish study
Journal of assisted reproduction and genetics · 2026
- Impact of Deoxynivalenol, Cytokines, and Particulate Matter on Human Trophoblast Cells.
Lab dish study
International journal of molecular sciences · 2026
- Association of estradiol and progesterone levels on human chorionic gonadotropin day with pregnancy outcomes in IVF/ICSI fresh embryo transfer.
Lab dish study
Frontiers in endocrinology · 2026
- A retrospective cohort study on the impact of gonadotropin dose on embryo quality and pregnancy outcome: identification of optimal dose range.
Lab dish study
Frontiers in medicine · 2026
- Reverse-Phase High-Performance Liquid Chromatography/Mass Spectrometry (RP-LC-MS/MS, Label-Free Method) for Component Analysis of Gonadotropin Drugs.
Journal of mass spectrometry : JMS · 2026
- Association of human chorionic gonadotropin and post-pregnancy persistent enhanced myometrial vascularity.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
- Analysis of human chorionic gonadotropin glycoforms by nano-liquid chromatography-mass spectrometry: novel strategies based on mobile phase additive and adduct dissociation.
Analytical and bioanalytical chemistry · 2026
- Serum hCG reference values in menopausal women across four immunoassay platforms: implications of renal function for clinical interpretation.
Clinical chemistry and laboratory medicine · 2026
- Pituitary Axis Impacts and Effectiveness of Clomiphene and Human Chorionic Gonadotropin in Treating Hypogonadism: Cohort Study.
The world journal of men's health · 2026
- Elevated beta-human chorionic gonadotropin levels in a patient with end-stage renal disease awaiting kidney transplantation: a case report.
Journal of medical case reports · 2026
- Chronic Ectopic Pregnancy Presenting as a Complex Adnexal Mass With Negative Beta-Human Chorionic Gonadotropin Mimicking Ovarian Malignancy: A Case Report.
Cureus · 2026
- Therapeutic benefits of gonadotropins in male hypogonadotropic hypogonadism: a focus on spermatogenesis and fertility.
Reproduction & fertility · 2026
- Prognostic utility of serum beta human chorionic gonadotropin level following single euploid embryo transfer for live birth.
Fertility and sterility · 2026
- Combined triple screening and BMI models for gestational diabetes prediction.
Turkish journal of obstetrics and gynecology · 2026
- Au-IDE/LFA biosensor: an integrated sensing platform with lateral flow immunoassay for quantitative detection of hCG hormone using non-faradaic continuous FFT-admittance voltammetry.
BMC biotechnology · 2026
- Spontaneous Conception During Ovarian Stimulation Complicated by Severe Ovarian Hyperstimulation Syndrome (OHSS) With Atypical β-Human Chorionic Gonadotropin (β-hCG) Trends: A Case Report.
Cureus · 2026
- Unexpected elevation of β-hCG in EGFR-mutant lung adenocarcinoma: a case study and implications for clinical practice.
BMC pulmonary medicine · 2026
- Peak LH/FSH ratio is associated with hCG response in prepubertal boys with micropenis
Journal not recorded · 2026
- Gestational Trophoblastic Neoplasia With Intracardiac Metastatic Masses.
JACC. Case reports · 2026
- Gestational Trophoblastic Disease in a Resource-Limited Setting: A Prospective Study of Molar Pregnancy at a Teaching Hospital in Northeast India.
Cureus · 2026
- Analyte-containing dilution extends the functional range of clinical immunoassays for volume-limited specimens.
Clinica chimica acta; international journal of clinical chemistry · 2026
- Locally Advanced Invasive Mole in the Presence of Low Serum β-hCG: A Case Report.
International journal of women's health · 2026
- Abdominal complete hydatidiform mole following uterine evacuation: a case report.
Frontiers in oncology · 2026
- Evaluation of Leydig cell activity using single-dose hCG stimulation in prepubertal children suspected of hypogonadism: experience from a tertiary institution.
Annals of pediatric endocrinology & metabolism · 2026
- Metastatic Epithelioid Trophoblastic Tumor Following Incomplete Methotrexate Therapy for Ectopic Pregnancy: A Case Report and Multimodal Management.
Cureus · 2026
- Non-gestational choriocarcinoma presenting as cervical lymphadenopathy in a male patient: a case report.
Frontiers in oncology · 2026
- When Methotrexate Is Not Enough: Hysteroscopic Management of an Angular Pregnancy With Discordant Beta-Human Chorionic Gonadotropin (b-hCG) and Ultrasound Findings.
Cureus · 2026
- Predicting live birth following single euploid frozen-embryo transfer via β-hCG dynamics: iHOPE prognostic model with external validation.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
- Application of transvaginal color doppler ultrasound in early diagnosis of threatened abortion and its correlation with serum levels of β - hCG and CA125.
Frontiers in endocrinology · 2026
- Gestational choriocarcinoma following an ectopic pregnancy: A diagnostic dilemma in low-resource settings.
Radiology case reports · 2026
- Abdominal ectopic pregnancy - misdiagnosed upper abdominal pain: A case report.
Medicine · 2026
- Risk factors of Intrauterine Pregnancy Loss Following Surgical of Heterotopic Pregnancy:A Retrospective Analysis of 102 Cases from a Single Center
Journal not recorded · 2026
- Unilateral unruptured twin tubal ectopic pregnancy: a case report.
Journal of medical case reports · 2026
- ACOG Clinical Consensus No. 11: Management of Positive Human Chorionic Gonadotropin Test Results in Nonpregnant Patients Without Gynecologic Malignancy.
Obstetrics and gynecology · 2026
- Chronic tubal ectopic pregnancy with undetectable serum β-hCG mimicking a large ovarian endometrioma: A case report.
Case reports in women's health · 2026
- Giant testicular seminoma with atypical painful presentation and delayed diagnosis: a case report.
Journal of surgical case reports · 2026
- Diagnostic challenges of epithelioid trophoblastic tumor in a patient with elevated beta-human chorionic gonadotropin (β-hCG) levels: a case description.
Quantitative imaging in medicine and surgery · 2026
- False-positive point-of-care urine beta human chorionic gonadotropin testing: Insights from two clinical cases.
Annals of clinical biochemistry · 2026
- An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development
Journal not recorded · 2026
- Predictive Value of Day 1–4 β-hCG Change for Single-Dose Methotrexate Failure in Tubal Ectopic Pregnancy
Journal not recorded · 2026
- Serum human chorionic gonadotropin can predict live birth 7 days after frozen-thawed blastocyst transfer.
F&S reports · 2025
- Intrauterine human chorionic gonadotropin administration before embryo transfer (IHABT): an individual participant data meta-analysis of randomized controlled trials.
Review of earlier work
Human reproduction update · 2026
- Treatment Selection Based on Dominant Tumor Biology in Endometrial Carcinoma with Choriocarcinomatous Differentiation: A Case-Based Review.
Review of earlier work
Current oncology (Toronto, Ont.) · 2026