Gonadorelin
Approved medicineThe FDA has approved a version of this as a medicine, so it has been through large studies in people.
Also called GnRH / LHRH / Factrel / Lutrelef
A natural hormone signal. Often prescribed alongside testosterone therapy to keep the body's own production going.
Can a doctor prescribe this?
Yes. Pharmacies are allowed to make it, so a doctor can write a prescription for it.
The FDA has approved a version of this as a medicine.
Historically FDA-approved. Widely compounded with a prescription.
Official status: On the 503A bulks list. Checked 2026-08-04.
Lab suppliers we list: 5
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In human trials
See source wording
for 10 days
A Phase II Study Evaluating Intravenous Melphalan With Autologous Whole Blood Stem Cell Transplantation Over Three Cycles In Patients With Castration-Resistant Prostate Cancer (MEL-CAP)PHASE2, PHASE3 · NCT01907009
“Patients will receive Melphalan in three cycles In the first cycle they recieve 60mg/m2 and then 40mg/m2 in the next two cycles..”
In animal studies
See source wording
cats · once daily
Stress-related cortisol and progesterone concentrations influence the success of ovulation induction in estrous cats.Theriogenology · 2026
“This study aimed to investigate the stress and hormone related factors influencing ovulatory success in 78 queens induced to ovulate by vaginal stimulation (VS), GnRH (50 μg gonadorelin), and human chorionic gonadotropin (hCG, 250 IU) in domestic cats.”
See source wording
cats · every 3 weeks
Ovarian remnant syndrome in a 2-year-old cat with inconclusive diagnostics.JFMS open reports · 2026
“On evaluation at a referral hospital, serum anti-Müllerian hormone (AMH) concentration was 0.14 ng/ml, consistent with a spayed female, and serum progesterone concentration was 1.3 ng/ml, which is not consistent with the presence of active luteal tissue.”
60 mcg
fish ·
Effects of gonadorelin on gonadotropin expression, plasma sex steroid concentrations and ovarian follicle dynamics in mature tambaqui (Colossoma macropomum).Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2025
“Gonadorelin at 60 μg kg -1 body weight had no statistical effect on lhβ expression, but decreased fshβ expression in females (p = 0.021).”
See source wording
rabbits ·
Effects of Kisspeptin on rabbit ovulation: a comprehensive study of ovulatory, endocrine and histological response.Theriogenology · 2025
“Multiparous New Zealand White × California does were assigned to three groups: control group (0.5 % saline solution, i.v.), GnRH group (20 μg gonadorelin, i.m.), and Kp10 group (250 μg Kp10, i.v.).”
See source wording
pigs · twice daily · for 4 days
Pregnancy and lambing rates following direct transfer of vitrified embryos in field ewes of Bangladesh.Journal of advanced veterinary and animal research · 2025
“Superovulation was induced with 25 mg porcine follicle-stimulating hormone per donor twice daily for 4 days.”
- Increasing gonadorelin hydrochloride dose at the first GnRH of breeding Ovsynch enhances luteinizing hormone release, ovulatory response, and pregnancy in first-service lactating dairy cows.
Journal of dairy science · 2026
- Diagnostic performance of a simplified GnRH stimulation test in central precocious puberty: a multicentre study
Journal not recorded · 2026
- Reproductive efficiency of Bos indicus cows under different estradiol-free ovulation synchronization protocols.
Theriogenology · 2026
- Estradiol treatment and double dose of GnRH for resynchronization protocols and timed artificial insemination in lactating dairy cows.
Theriogenology · 2026
- Stress-related cortisol and progesterone concentrations influence the success of ovulation induction in estrous cats.
Theriogenology · 2026
- A new cetrorelix-based estrogen-free ovarian synchronization protocol for fixed-time artificial insemination in beef cattle.
Theriogenology · 2026
- Ovarian remnant syndrome in a 2-year-old cat with inconclusive diagnostics.
JFMS open reports · 2026
- Diagnostic accuracy of the triptorelin stimulation test for central precocious puberty in girls.
Endocrine connections · 2025
- Effects of gonadorelin on gonadotropin expression, plasma sex steroid concentrations and ovarian follicle dynamics in mature tambaqui (Colossoma macropomum).
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2025
- Is the triptorelin stimulation test comparable to the gonadorelin stimulation test in diagnosing central precocious puberty in boys?
Annals of pediatric endocrinology & metabolism · 2025
- Buserelin shortens the estrus-to-ovulation interval and improves the pregnancy outcomes in gilts treated with a fixed-time artificial insemination.
Frontiers in veterinary science · 2025
- Ovarian response in water buffaloes induced to ovulate outside the breeding season
Journal not recorded · 2025
- Economics of Using GnRH on Day 5 After Timed Artificial Insemination in a Modified Double-Ovsynch Protocol at a Low-Fertility Dairy Farm.
Veterinary sciences · 2025
- Effects of Kisspeptin on rabbit ovulation: a comprehensive study of ovulatory, endocrine and histological response.
Theriogenology · 2025
- Pregnancy and lambing rates following direct transfer of vitrified embryos in field ewes of Bangladesh.
Journal of advanced veterinary and animal research · 2025
- Effect of 200 μg of gonadorelin hydrochloride at the first GnRH of a CO-Synch program on ovulation rate and pregnancies per artificial insemination in Holstein heifers.
Journal of dairy science · 2024