Glutathione

500 mg

by mouth · twice daily · for 1 month

Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized PeriodontitisPHASE1, PHASE2 · NCT03533972

“subjects will be provided with Ashwagandha capsules 500 mg twice daily, after meals with plain water for 1 month.”

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by mouth · twice daily

Effects of Selenium and Melatonin on Ocular Ischemic SyndromeEARLY_PHASE1 · NCT04005222

“The patients in this group were supplemented with oral selenium at 0.1mg/kg doses twice daily for one month.”

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by mouth · for 2 days

Glutathione Levels and CompulsivityNA · NCT02794389

“1200mg for 2 days 2400mg for 7 days.”

900 mg

by mouth · for 28 weeks

N-Acetyl-Cysteine (NAC) in Early Phase Schizophrenia Spectrum PsychosisPHASE2 · NCT01354132

“900 mg effervescent PharmaNAC tablet in water or juice: two tablets in the AM, one tablet in PM.”

50 mg

for 10 months

The Impact of Zinc Supplementation on Left Ventricular Function in Nonischemic CardiomyopathyPHASE1 · NCT00696410

“Zinc acetate 50 mg po TID for 10 months.”

75 mcg/Kg

under the skin · every 3 days

Treating Oxidative Stress in Children With AutismNA · NCT00692315

“75 ug/Kg methylB12 every 3 days by subcutaneous injection.”

121 mg

Cysteine Supplementation in Critically Ill NeonatesPHASE2, PHASE3 · NCT00254176

“cysteine-HCl supplementation 121 mg per kg per day.”

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Glutathione and Its Precursors in HIV-Infected PatientsPHASE2 · NCT00910442

“Dietary supplement:N-acetylcysteine 1g/day and Glutamine 20g/day for 7 consecutive days.”

900 mg

daily · for 8 weeks

GWICTIC: NAC Mechanistic Study in Gulf War VeteransEARLY_PHASE1 · NCT04987775

“900mg 2x daily.”

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by mouth · twice per day

Efficacy of N-Acetylcysteine in Treatment of Overt Diabetic NephropathyPHASE2, PHASE3 · NCT00556465

“600 mg of effervescent N-acetylcysteine tablet twice per day for three months.”

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for 14 days

Effect of the Combination of Pterostilbene Cocrystal With Silybin and Nicotinamide Riboside on Exercise-Induced Oxidative StressNA · NCT07024966

“Participants will take 2 sachets, each containing 340 mg of ccPT, silybin and nicotinamide riboside, and 1.91 g of excipients..”

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by mouth · for 12 weeks

Black Seed Oil in ADHDPHASE2 · NCT06542887

“Participants will continue receiving their treatment with atomoxetine at a dose of 0.5-1.4 mg/kg/day.”

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by mouth

A Study of Glutathione in Children With Autism Spectrum DisorderPHASE4 · NCT05954052

“The proposed dose range for Glutathione in this study will be 1000mg-3000mg/day based on the subject's weight.”

65 mg/kg/day

by mouth

The Role of Oral Glutathione on Growth Parameters in Children With Cystic FibrosisPHASE2 · NCT03020719

“Oral Glutathione oral powder at 65mg/kg/day.”

See source wording

into a vein

Treatment of Severe Alcoholic Hepatitis With Corticoids Plus N Acetyl Cysteine Versus Corticoids AlonePHASE3 · NCT00863785

“40 mg/d prednisolone N Acetyl Cysteine infusion 150mg/kg in 30 minutes then 50 mg/kg in 4 h then 100mg/kg in 16 h and finally 100mg/d2 to d5.”

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rats · by mouth · for 7 days

Redox-Associated Renal and Male Reproductive Alterations Following Dexamethasone Exposure in Male Rats: Histopathological and Spermatological Evaluations.Journal of applied toxicology : JAT · 2026

“Thirty-five adult male Wistar rats were divided into five groups (n = 7): control, DEX (7 mg/kg/day, intraperitoneally, for 7 days), GSH (0.2 g/kg/day, oral gavage, for 7 days), co-administration (DEX + GSH for 7 days; DG7), and extended treatment (DEX + GSH for 7 days followed by seven additional days of GSH; DG14).”

100 mg

rats · another route · for 8 weeks

[Paeoniflorin alleviates osteoarthritis by inhibiting chondrocyte ferroptosis via Nrf2/GPX4 signaling pathway].Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica · 2026

“In vivo, 60 SD rats were randomly divided into control, model, Fer-1, and paeoniflorin low-, medium-, and high-dose(25, 50, and 100 mg·kg~(-1)) groups.”

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rats · into a muscle

Cardioprotective effects of acetate supplementation against fructose-induced cardiac injury in pregnant Wistar rats.Current research in physiology · 2026

“Methods Thirty female Wistar rats with a mean weight of 135 ± 15g were divided into pregnant (P) and non-pregnant (NP) cohorts (n = 15 each).”

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rats · for 14 days

The Protective Effect of Galangin on Histopathological Lesions, Immunohistochemical Findings and Spermatological Parameters in Phthalate-Induced Testicular Damage in Rats.Anatomia, histologia, embryologia · 2026

“For this purpose, experimental groups were designed as follows: (Control: no treatment applied, Solvent: 5 mL/kg/day corn oil applied, Phthalate (PHT): 2 g/kg DEHP applied, Galangin GL-5, GL-10 and GL-15: galangin applied at doses of 5, 10 and 15 mg/kg, respectively, PHT + GL-5, PHT + GL-10 and PHT + GL-15: galangin applied at doses of 5, 10 and 15 mg/kg, respectively, 1 h after 2 g/kg DEHP dissolved in 5 mL/kg corn oil).”

50 mg/kg

mice · by mouth

Efficient pulmonary-targeted therapy and mechanistic insights of a novel glutathione dry powder inhaler in a model of radiation-induced lung injury.Toxicology and applied pharmacology · 2026

“In a murine RILI model, GSH-DPI (50 mg/kg, intrapulmonary administration) demonstrated superior efficacy in alleviating histopathological damage, restoring immune homeostasis, and reducing oxidative stress and pro-inflammatory cytokine expression compared to equimolar liquid GSH or high-dose oral administration.”

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mice · another route

In vivo evaluation of the neuroprotective effects of melittin on doxorubicin-induced acute and chronic neurotoxicity in mice.Brain research · 2026

“Melittin was administered at doses of 0.1, 0.2, and 0.4 mg/kg.”

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mice · by mouth · for 30 days

Naringenin Attenuates Cisplatin-Induced Hepatotoxicity and Nephrotoxicity by Restoring Glutathione Homeostasis and Suppressing Lipid Peroxidation in a Murine ModelJournal not recorded · 2026

“The present study investigated whether oral naringenin supplementation (50 mg/kg body weight/day for 30 days) could mitigate cisplatin-induced oxidative injury to the liver and kidney in male Swiss albino mice.”

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rats · under the skin

Algerian bee Venom attenuates formaldehyde-induced acute inflammation and oxidative stress in male rats.Environmental analysis, health and toxicology · 2026

“One hour later, rats received either subcutaneous bee venom (0.76 mg/kg) or oral diclofenac sodium (10 mg/kg) as a reference drug.”

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rats · by mouth

Hepatotoxic and nephrotoxic effects of etoxazole in rats: dose-response relationships, oxidative stress mechanisms, and provisional NOAEL/LOAEL estimates.Toxicology mechanisms and methods · 2026

“Six groups of seven female rats each received normal control (NC) or ETX at 25, 100, 250, 500, or 750 mg/kg/day by gavage for 28 consecutive days.”

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rats · for 30 days

Protective effects of L-theanine against bisphenol A-induced oxidative stress and gut microbiota disruption in Wistar rats.Molecular biology reports · 2026

“Methods and results In the present study, female Wistar albino rats were randomly allocated into three groups: control, BPA (50 mg/kg/day), and BPA + LTN (100 mg/kg/day) and treated for 30 days.”

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rats · for 6 months

Long-Term Low-Dose of Nitrate Administration Improves Antioxidant Defence System in Insulin-Sensitive Tissues of Type 2 Diabetic Rats.Endocrinology, diabetes & metabolism · 2026

“T2D was induced using a high-fat diet followed by a low dose of streptozotocin (30 mg/kg).”

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pigs · weekly

Effect of S-abscisic acid supplementation on the growth performance and antioxidant status of nursery pigs.Translational animal science · 2026

“Treatments included a conventional nursery diet (Control) and 3 diets which used the Control formulation with increasing S-ABA (0.5, 1.0 and 5.0 mg/kg).”

15 g

cats · by mouth · for 3 months

Metabolic and Antioxidant Status, Telomere Lengths of Individuals With Prediabetes in Context of 3 Months of Insoluble Dietary Fibre Intake During the SARS-CoV2 Pandemic.Endocrinology, diabetes & metabolism · 2026

“Methods The study included 29 adults with impaired fasting glucose (IFG) who received 15 g/day of IF for 3 months.”

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chickens · another route · daily

The Effects of Reduced Glutathione on Growth Performance, Intestinal Inflammation, and Gut Microbiota in Immune-Stressed Broiler Chickens.Animals : an open access journal from MDPI · 2026

“One-day-old broilers were randomly assigned to five groups: group K (control), group L (lipopolysaccharide), and three glutathione supplementation groups, Y1 (50 mg/kg), Y2 (100 mg/kg), and Y3 (200 mg/kg).”

25 mg/kg

rats ·

Antioxidant Properties of Novel Lipophilic Fluoroquinolone Compounds Against Oxidative Stress Induced by Acetaminophen and Carbon Tetrachloride in Male Wistar Rats.Biomolecules · 2026

“FQ compounds (25 mg/kg) were administered six hours after CCl 4 or APAP administration.”