GHRP-2
Tested in peopleGet notified when the evidence changes.
It has been tested in people, but it is not an approved medicine. The studies are usually small.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-05-14
Also called Pralmorelin / KP-102 / Growth Hormone Releasing Peptide 2
Triggers a burst of growth hormone. Approved in Japan as a diagnostic test, not as a treatment.
Official status: 503A Category 3 – nominated without adequate support · Checked 2026-05-14
Can a doctor prescribe this?
- Small pharmacy (503A)
- Category 3 — not enough evidence sent in
- Large outsourcing facility (503B)
- Category 1 — under review, allowed for nowall routes except injection and nasal use
FDA entry: “GHRP-2 (except for injectable and nasal routes of administration)” · document dated 2025-03-21
Category 2 — FDA flagged a safety concerninjection and nasal use onlyFDA entry: “GHRP-2 (for injectable and nasal routes of administration)” · document dated 2025-03-21
The FDA has "GHRP-2" in Category 3 of the substances put forward for small-pharmacy (503A) compounding: someone did put it forward, but what was sent in did not include enough evidence for the FDA to judge it. The separate list for large outsourcing facilities (503B) splits it by route, and that split is recorded on the timeline rather than as one flat category.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
About the 503B list: FDA states it does not intend to place bulk drug substances nominated on or after 7 January 2025 into these categories. The category document is therefore not updated for new nominations — an older document date reflects a frozen process, not a lapsed one.
Lab suppliers we list: 7
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Study in peopleAssessment of anterior pituitary reserve capacity based on growth hormone response to growth hormone-releasing peptide-2 test in the elderly.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2023
- Study in peopleEstradiol regulates GH-releasing peptide's interactions with GH-releasing hormone and somatostatin in postmenopausal women.
European journal of endocrinology · 2014
- Study in peopleDifferential pulsatile secretagogue control of GH secretion in healthy men.
American journal of physiology. Regulatory, integrative and comparative physiology · 2013
- Study in peopleGender, sex-steroid, and secretagogue-selective recovery from growth hormone-induced feedback in older women and men.
The Journal of clinical endocrinology and metabolism · 2011
- Study in peopleComplex regulation of GH autofeedback under dual-peptide drive: studies under a pharmacological GH and sex steroid clamp.
American journal of physiology. Endocrinology and metabolism · 2011
- Study in peoplePre- versus postmenopausal age, estradiol, and peptide-secretagogue type determine pulsatile growth hormone secretion in healthy women: studies using submaximal agonist drive and an estrogen clamp.
The Journal of clinical endocrinology and metabolism · 2010
- Study in peopleSecretagogue type, sex-steroid milieu, and abdominal visceral adiposity individually determine secretagogue-stimulated cortisol secretion.
European journal of endocrinology · 2010
- Study in peopleDeterminants of GH-releasing hormone and GH-releasing peptide synergy in men.
American journal of physiology. Endocrinology and metabolism · 2009
- Study in peoplePreservation of GHRH and GH-releasing peptide-2 efficacy in young men with experimentally induced hypogonadism.
European journal of endocrinology · 2009
- Study in peopleGonadal status and body mass index jointly determine growth hormone (GH)-releasing hormone/GH-releasing peptide synergy in healthy men.
The Journal of clinical endocrinology and metabolism · 2008
- Study in peopleEstimation of the size and shape of GH secretory bursts in healthy women using a physiological estradiol clamp and variable-waveform deconvolution model.
American journal of physiology. Regulatory, integrative and comparative physiology · 2007
- Study in peoplePeripheral estrogen receptor-alpha selectively modulates the waveform of GH secretory bursts in healthy women.
American journal of physiology. Regulatory, integrative and comparative physiology · 2007
- Study in peopleObese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intake.
Obesity (Silver Spring, Md.) · 2006
- Study in peopleShort-term testosterone supplementation does not activate GH and IGF-I production in postmenopausal women.
Clinical endocrinology · 2005
- Study in peopleJoint mechanisms of impaired growth-hormone pulse renewal in aging men.
The Journal of clinical endocrinology and metabolism · 2005
- Study in peopleTestosterone supplementation in healthy older men drives GH and IGF-I secretion without potentiating peptidyl secretagogue efficacy.
European journal of endocrinology · 2005
- Study in peopleThe combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone.
Clinical endocrinology · 2002
- Study in peopleSynergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise.
American journal of physiology. Regulatory, integrative and comparative physiology · 2000
- Study in peoplePharmacokinetics and pharmacodynamics of growth hormone-releasing peptide-2: a phase I study in children.
The Journal of clinical endocrinology and metabolism · 1998
- Study in peopleDiagnostic studies with intravenous and intranasal growth hormone-releasing peptide-2 in children of short stature.
The Journal of clinical endocrinology and metabolism · 1995
- Data from people, not a trialDifferentiating hypothalamic from pituitary adrenal insufficiency: underlying causes and diagnostic utility of the corticotropin-releasing hormone and growth hormone-releasing peptide-2 stimulation tests.
Endocrine journal · 2026
- Data from people, not a trialAssociation between overweight and growth hormone secretion in patients with non-functioning pituitary tumors.
PloS one · 2022
- Data from people, not a trialInvestigation of the clinical significance of the growth hormone-releasing peptide-2 test for the diagnosis of secondary adrenal failure.
Endocrine journal · 2016
- Data from people, not a trialIdentification of the growth-hormone-releasing peptide-2 (GHRP-2) in a nutritional supplement.
Drug testing and analysis · 2010
- Animal study, larger animalsDiurnal and Daily Variations in Growth Hormone and Growth Hormone Stimulation Test in Male Cynomolgus Monkeys.
In vivo (Athens, Greece) · 2026
- Animal study, rats or miceGrowth Hormone-Releasing Peptide 2 May Be Associated With Decreased M1 Macrophage Production and Increased Histologic and Biomechanical Tendon-Bone Healing Properties in a Rat Rotator Cuff Tear Model.
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association · 2025
- Animal study, rats or miceGhrelin receptor agonist, GHRP-2, produces antinociceptive effects at the supraspinal level via the opioid receptor in mice.
Peptides · 2014
- Animal study, rats or miceGHRP-2 attenuates burn-induced dysfunctions in rodents.
Advances in experimental medicine and biology · 2009
- Animal study, rats or miceACTH releasing activity of KP-102 (GHRP-2) in rats is mediated mainly by release of CRF.
Naunyn-Schmiedeberg's archives of pharmacology · 2005
- Animal study, larger animalsGeneral pharmacology of KP-102 (GHRP-2), a potent growth hormone-releasing peptide.
Arzneimittel-Forschung · 2004
- Animal study, rats or miceE2 supplementation selectively relieves GH's autonegative feedback on GH-releasing peptide-2-stimulated GH secretion.
The Journal of clinical endocrinology and metabolism · 2001
- Lab dish studyBenchmark for Setting ACTH Cell Dosage in Clinical Regenerative Medicine for Post-Operative Hypopituitarism.
Diseases (Basel, Switzerland) · 2025
- Lab dish studyPharmacological characteristics of KP-102 (GHRP-2), a potent growth hormone-releasing peptide.
Arzneimittel-Forschung · 2004
- Lab test method, not a health studyDetermination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin.
Drug testing and analysis · 2015
- Lab test method, not a health studyDetection of GHRP-2 and GHRP-6 in urine samples from athletes.
Drug testing and analysis · 2015
- Lab test method, not a health studyIdentification and quantification of the doping agent GHRP-2 in seized unlabelled vials by NMR and MS: a case-report.
Drug testing and analysis · 2014
- Lab test method, not a health studyDetermination of growth hormone secretagogue pralmorelin (GHRP-2) and its metabolite in human urine by liquid chromatography/electrospray ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM · 2010
- Hypothesis, not a tested studyPreservation of growth hormone secretion in response to growth hormone-releasing peptide-2 during prednisone therapy.
Metabolism: clinical and experimental · 1999
- Unveiling the Role of Melatonin in Coronary Heart Disease: Identification and Experimental Validation of Novel Biomarkers
2026
- One Case of Sudden Isolated Adrenocorticotropic Hormone (ACTH) Deficiency Diagnosed Based on Repeated Hypoglycemic Attacks.
Cureus · 2025
- On the road of dried blood spot sampling for antidoping tests: Detection of GHRP-2 abuse.
Drug testing and analysis · 2021
- Identification of a novel growth hormone releasing peptide (a glycine analogue of GHRP-2) in a seized injection vial.
Drug testing and analysis · 2019
- Laparoscopic Sleeve Gastrectomy Resolves Low GHRP-2-Stimulated Growth Hormone Levels in Obese Patients.
Obesity surgery · 2017
- Effects of GHRP-2 and Cysteamine Administration on Growth Performance, Somatotropic Axis Hormone and Muscle Protein Deposition in Yaks (Bos grunniens) with Growth Retardation.
PloS one · 2016
- The arginine and GHRP-2 tests as alternatives to the insulin tolerance test for the diagnosis of adult GH deficiency in Japanese patients: a comparison.
Endocrine journal · 2013
- Concordant and discordant adrenocorticotropin (ACTH) responses induced by growth hormone-releasing peptide-2 (GHRP-2), corticotropin-releasing hormone (CRH) and insulin-induced hypoglycemia in patients with hypothalamopituitary disorders: evidence for direct ACTH releasing activity of GHRP-2.
Endocrine journal · 2010
- Is there an undiscovered neurocircuit for regulating GH secretion? -Pitfalls of GHRP-2 and ITT as GH provocative tests-.
Endocrine journal · 2010
- Factors other than sex steroids modulate GHRH and GHRP-2 efficacies in men: evaluation using a GnRH agonist/testosterone clamp.
The Journal of clinical endocrinology and metabolism · 2009
- Novel relationships of age, visceral adiposity, insulin-like growth factor (IGF)-I and IGF binding protein concentrations to growth hormone (GH) releasing-hormone and GH releasing-peptide efficacies in men during experimental hypogonadal clamp.
The Journal of clinical endocrinology and metabolism · 2009
- Secretagogues govern GH secretory-burst waveform and mass in healthy eugonadal and short-term hypogonadal men.
European journal of endocrinology · 2008
- A simple diagnostic test using GH-releasing peptide-2 in adult GH deficiency.
European journal of endocrinology · 2007
- Tripartite control of growth hormone secretion in women during controlled estradiol repletion.
The Journal of clinical endocrinology and metabolism · 2007
- Activation of somatostatin-receptor subtype-2/-5 suppresses the mass, frequency, and irregularity of growth hormone (GH)-releasing peptide-2-stimulated GH secretion in men.
The Journal of clinical endocrinology and metabolism · 2004
- Changes in appetite and body weight in response to long-term oral administration of the ghrelin agonist GHRP-2 in growth hormone deficient children.
Journal of pediatric endocrinology & metabolism : JPEM · 2003
- Impact of estradiol supplementation on dual peptidyl drive of GH secretion in postmenopausal women.
The Journal of clinical endocrinology and metabolism · 2002
- Growth hormone/insulin-like growth factor-1 response to acute and chronic growth hormone-releasing peptide-2, growth hormone-releasing hormone 1-44NH2 and in combination in older men and women with decreased growth hormone secretion.
Endocrine · 2001
- Reduction of free fatty acids by acipimox enhances the growth hormone (GH) responses to GH-releasing peptide 2 in elderly men.
The Journal of clinical endocrinology and metabolism · 2000
- Tyr-Ala-Hexarelin, a synthetic octapeptide, possesses the same endocrine activities of Hexarelin and GHRP-2 in humans.
Journal of endocrinological investigation · 1999
- Growth hormone-releasing peptide-2 infusion synchronizes growth hormone, thyrotrophin and prolactin release in prolonged critical illness.
European journal of endocrinology · 1999
- GHRP-2, GHRH and SRIF interrelationships during chronic administration of GHRP-2 to humans.
Journal of pediatric endocrinology & metabolism : JPEM · 1996
- Growth hormone (GH)-releasing effects of synthetic peptide GH-releasing peptide-2 and GH-releasing hormone (1-29NH2) in children with GH insufficiency and idiopathic short stature.
Metabolism: clinical and experimental · 1995
- Review of earlier workThe emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
Frontiers in endocrinology · 2026
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What has happened so far
- 14 May 2026503A
FDA lists "GHRP-2" under 503A Category 3: Bulk Drug Substances Nominated Without Adequate Support. Read from the FDA 503A category document headed "Updated May 14, 2026".
- 21 March 2025503B
The same 503B list places GHRP-2 in Category 2 "for injectable and nasal routes of administration". Category 2 is the list of substances raising significant safety risks. In plain terms: an outsourcing facility may not use GHRP-2 for injection or nasal use. Read from the FDA 503B bulk drug substances category list, document dated March 21, 2025 - seventeen months old at the time of this entry.
- 21 March 2025503B
The 503B list places GHRP-2 in Category 1 "except for injectable and nasal routes of administration". Category 1 means FDA does not intend to take action against its use in compounding while the nomination is under evaluation. In plain terms: an outsourcing facility may use GHRP-2 for non-injectable, non-nasal preparations. Read from the FDA 503B bulk drug substances category list, document dated March 21, 2025 - seventeen months old at the time of this entry.