FOXO4-DRI
Very early researchGet notified when the evidence changes.
The research is at the earliest stage – mostly cells in a lab dish. It is far too early to say much.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-08-04
Also called FOXO4 D-Retro-Inverso / Proxofim
Designed to clear out old, damaged cells. Studied only in cells and mice so far.
Official status: Not nominated for 503A compounding · Checked 2026-08-04
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Not approved and not on the compounding list.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 5
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
No dosing information has been published in the research indexed here.
- Animal study, rats or miceFOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway.
Frontiers in bioengineering and biotechnology · 2025
- Animal study, rats or miceFOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells.
Experimental gerontology · 2024
- Animal study, rats or miceCellular Senescence Contributes to the Progression of Hyperoxic Bronchopulmonary Dysplasia.
American journal of respiratory cell and molecular biology · 2024
- Animal study, rats or miceFOXO4-D-Retro-Inverso targets extracellular matrix production in fibroblasts and ameliorates bleomycin-induced pulmonary fibrosis in mice.
Naunyn-Schmiedeberg's archives of pharmacology · 2023
- Animal study, rats or miceFOXO4 peptide targets myofibroblast ameliorates bleomycin-induced pulmonary fibrosis in mice through ECM-receptor interaction pathway.
Journal of cellular and molecular medicine · 2022
- Animal study, rats or miceFOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.
Aging · 2020
- Lab dish studyTargeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced pulmonary fibrosis.
JCI insight · 2021
- Lab dish studySenolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From <i>in vitro</i> Expanded Human Chondrocytes.
Frontiers in bioengineering and biotechnology · 2021
- Acylglycerol Kinase Sensitizes Glioblastoma to Temozolomide via Limiting Mitochondrial Damage Related Cellular Senescence.
Molecular carcinogenesis · 2026
- FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation.
Communications biology · 2025
- The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.
Nature communications · 2025
- Review of earlier workTargeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline.
Naunyn-Schmiedeberg's archives of pharmacology · 2026
- Review of earlier workFOXO4 as a Redox-Sensitive Regulator of Antioxidant Defense and Cellular Senescence: Cysteine-Based Signaling, p53 Interaction, and Therapeutic Targeting.
Antioxidants (Basel, Switzerland) · 2026
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