FGL
Animal studies onlyGet notified when the evidence changes.
Almost all the research is in animals. We do not know if the same thing happens in people.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-08-04
Also called FG Loop peptide / FGL-L
A peptide copied from a nerve cell adhesion protein, studied in rodents for memory.
The basics
- What is it?
- FGL mimics a loop of NCAM, a protein nerve cells use to stick together. Rodent studies have looked at learning, memory and inflammation in the brain.
Official status: Not nominated for 503A compounding · Checked 2026-08-04
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Not FDA approved and not on the U.S. compounding list. A doctor cannot prescribe it.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 2
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Study in peopleSerum FGL2 is correlated with the severity and psychological status of diarrhea-predominant irritable bowel syndrome.
Frontiers in medicine · 2026
- Study in peopleImmunological characterization of a long-lasting response in a patient with metastatic triple-negative breast cancer treated with PD-1 and LAG-3 blockade.
Scientific reports · 2024
- Study in peopleFluorescence-Guided Laparoscopy after Oral Hypericin Administration for Staging of Locally Advanced Gastric Cancer-A Pilot Study.
Journal of clinical medicine · 2024
- Study in peopleDiet-induced Fasting Ghrelin Elevation Reflects the Recovery of Insulin Sensitivity and Visceral Adiposity Regression.
The Journal of clinical endocrinology and metabolism · 2022
- Study in peopleThe effect of tourniquet type and thigh conicity on the length of hamstring autograft.
Journal of orthopaedic surgery (Hong Kong) · 2018
- Study in peopleTolerability, safety and pharmacokinetics of the FGLL peptide, a novel mimetic of neural cell adhesion molecule, following intranasal administration in healthy volunteers.
Clinical pharmacokinetics · 2007
- Data from people, not a trialFGL-1 plasma levels correlate with markers of inflammation and severe disease during SARS-CoV-2 infection.
Communications medicine · 2026
- Data from people, not a trialThe FGL-1/LAG-3 Axis is Associated With Disease Course in Alcohol-associated Hepatitis: A Preliminary Report.
Journal of clinical and experimental hepatology · 2025
- Data from people, not a trialPotential clinical value of fibrinogen-like protein 1 as a serum biomarker for the identification of diabetic cardiomyopathy.
Scientific reports · 2024
- Data from people, not a trialDoes eradication of Helicobacter pylori reduce hypergastrinaemia during long term therapy with proton pump inhibitors?
East African medical journal · 2003
- Animal study, larger animalsFunctionally Graded Lattice (FGL) Models for Predicting the Mechanical Properties of Femur Spongy Bone.
Biomedical engineering and computational biology · 2026
- Animal study, rats or miceThe activation of fibroblast growth factor receptor 1 provides therapeutic benefit in a mouse model of Alzheimer’s disease
2025
- Animal study, rats or miceEffects of Bioconverted Guava Leaf (<i>Psidium guajava</i> L.) Extract on Skeletal Muscle Damage by Regulation of Ubiquitin-Proteasome System and Apoptosis in Type 2 Diabetic Mice.
International journal of molecular sciences · 2025
- Animal study, rats or miceFGFR1 agonists alleviate pathology and cognitive impairment in an Alzheimer's disease mouse model.
Experimental neurology · 2025
- Animal study, rats or miceRegulatory Role of FGL-1 in Interorgan Communication by Controlling T Cell Homeostasis During the Onset of Sjögren Disease.
Arthritis & rheumatology (Hoboken, N.J.) · 2025
- Animal study, rats or mice[Clinical and experimental study on fuganlin oral liquid in treating repeated respiratory tract infection].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine · 1997
- Studied in worms or fishEffect of grape pomace fermented with probiotic microorganisms on growth performance, meat quality, antioxidant capacity, serum biochemistry and some cecal microorganisms in broiler chickens.
Tropical animal health and production · 2025
- Lab dish studyFgl-1 promotes the progression of endometrial adenocarcinoma through PI3K/AKT signal pathway.
Medical oncology (Northwood, London, England) · 2026
- Hypothesis, not a tested studyToward Fair Federated Graph Learning.
IEEE transactions on neural networks and learning systems · 2026
- Hypothesis, not a tested studyFederated Node Classification over Distributed Ego-Networks with Secure Contrastive Embedding Sharing.
Proceedings of the ... ACM International Conference on Information & Knowledge Management. ACM International Conference on Information and Knowledge Management · 2024
- Triple-stimuli-responsive and FGL-1-inhibiting polydopamine nanoparticles for synergistic chemo-photothermal immunotherapy of breast cancer.
Colloids and surfaces. B, Biointerfaces · 2026
- Quality and readability of patient information on robotic-assisted hip arthroplasty.
Annals of joint · 2026
- HarmoFGL: Harmonizing GNN Latent Factors for Federated Graph Learning.
IEEE transactions on neural networks and learning systems · 2026
- Solid-State Fermentation of <i>Jatropha curcas</i> Cake by <i>Pleurotus ostreatus</i> or <i>Ganoderma lucidum</i> Mycelium to Determine Multi-Bioactivities.
Foods (Basel, Switzerland) · 2026
- Glucose and Lactate Cooperatively Deprived by a PD-1-Presenting Nanoemulsion for Potentiated Antitumor Immunotherapy.
ACS nano · 2026
- Federated Subgraph Learning via Global-Knowledge-Guided Node Generation.
Sensors (Basel, Switzerland) · 2025
- Effect of a Laparoscopic Donor Nephrectomy in Healthy Living Kidney Donors on the Acute Phase Response Using Either Propofol or Sevoflurane Anesthesia.
International journal of molecular sciences · 2025
- Hepatokines modulation in obesity: which exercise training model is better in men with obesity?
Frontiers in endocrinology · 2025
- FGL-1 binding to LAG-3 inhibits T cell activation via disruption of CD28 and TCR signaling
2025
- Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma.
Nature communications · 2025
- Application of fused graphical lasso to statistical inference for multiple sparse precision matrices.
PloS one · 2024
- Nose-to-brain delivery of hyaluronate - FG loop peptide conjugate for non-invasive hypoxic-ischemic encephalopathy therapy.
Journal of controlled release : official journal of the Controlled Release Society · 2019
- Can Periodical Examinations of Employees Be Useful in Detection of Glycaemia Impairment and Improving Patients' Adherence to Medical Recommendations?
International journal of environmental research and public health · 2018
- Gonadotrophin-releasing hormone agonist therapy for hirsutism is as effective as high dose cyproterone acetate but results in a longer remission.
Human reproduction (Oxford, England) · 1997
- No abstract available, not yet classifiedPAS--phosphomolybdic acid--Sirius supra blue FGL-CF. Stain for demonstration of glomerular fibrosis.
Archives of pathology · 1968
- Review of earlier workPharmacogenomic-Based GWAS Meta-Analyses Coupled with Genetic and Epigenetic Liability Testing Connects Facial and Emotional Recognition Systems to Spectrum Disorders, Schizophrenia, Depression, and Anxiety.
Current pharmaceutical biotechnology · 2026
- Review of earlier workHepassocin (FGL-1) as a Hepatokine in Liver Physiology and Metabolic Dysfunction: A Narrative Review.
International journal of molecular sciences · 2026
- Review of earlier workAligning Condensed Graph via Hashing: A New Insight for Federated Graph Learning.
IEEE transactions on pattern analysis and machine intelligence · 2026
- Review of earlier workA Peptide Inhibitor of Lymphocyte Activation Gene-3 Interaction with Fibrinogen-like Protein 1 Synergizes with Programmed Death-Ligand 1 Blockade to Restore T Cell Activity and Inhibit Tumor Growth.
Biomaterials research · 2026
- Review of earlier workCharacteristic Computed Tomography Findings in Female Patients with Secondary Genital Lymphedema.
Lymphatic research and biology · 2025
- Review of earlier workFibrinogen superfamily proteins: Key regulators in hepatic disorders.
World journal of experimental medicine · 2025
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