Epitalon
Very early researchGet notified when the evidence changes.
The research is at the earliest stage – mostly cells in a lab dish. It is far too early to say much.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-03-30
Also called Epithalon / AEDG peptide / Ala-Glu-Asp-Gly
A four-part peptide studied in Russian ageing research. The work has not been repeated elsewhere and there is no approved use.
The basics
- What is it?
- A four-part lab-made peptide from Russian research on ageing.
- What do we know?
- Very little. A handful of Russian papers report effects on ageing markers.
- What do we still not know?
- Almost everything. Nobody outside those groups has repeated the work.
Official status: Not nominated for 503A compounding · Checked 2026-03-30
Can a doctor prescribe this?
- Small pharmacy (503A)
- Reviewed by FDA — see timeline
- Large outsourcing facility (503B)
- Never put forward to FDA
Not FDA approved and not on the 503A bulks list.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 16
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Animal study, larger animalsEpitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development.
Life sciences · 2025
- Animal study, rats or miceEpitalon protects against post-ovulatory aging-related damage of mouse oocytes <i>in vitro</i>.
Aging · 2022
- Animal study, rats or mice[Protective effect of melatonin and epithalon on hypothalamic regulation of reproduction in female rats in its premature aging model and on estrous cycles in senescent animals in various lighting regimes].
Advances in gerontology = Uspekhi gerontologii · 2013
- Animal study, rats or miceMelatonin and pineal gland peptides are able to correct the impairment of reproductive cycles in rats.
Current aging science · 2012
- Animal study, rats or mice[The influence of melatonin and epithalon on blood leukocyte count and leukocyte alkaline phosphatase in rats under different lighting conditions during ontogenesis].
Advances in gerontology = Uspekhi gerontologii · 2008
- Animal study, rats or miceEffects of intranasal administration of epitalon on neuron activity in the rat neocortex.
Neuroscience and behavioral physiology · 2007
- Animal study, rats or miceAntioxidant properties of geroprotective peptides of the pineal gland.
Archives of gerontology and geriatrics · 2007
- Animal study, rats or miceEffect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.
Bulletin of experimental biology and medicine · 2007
- Animal study, rats or mice[Effect of age, different light conditions, melatonin, and epitalon on lysosomal proteinase activity in the liver and kidneys of rats].
Advances in gerontology = Uspekhi gerontologii · 2006
- Animal study, rats or miceEffect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.
In vivo (Athens, Greece) · 2006
- Animal study, rats or mice[Intranasal epitalon infusion modulates neuronal activity in the rat neocortex].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova · 2006
- Animal study, rats or micePineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.
Neuro endocrinology letters · 2002
- Studied in worms or fishEffect of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the morphology of the thymus in hypophysectomized young and old birds.
Bulletin of experimental biology and medicine · 2013
- Studied in worms or fish[Effects of epithalon and cortagene on immunity and hemostasis in neonatally hypophysectomized chicken and old birds].
Advances in gerontology = Uspekhi gerontologii · 2008
- Lab dish studyCorrection: Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Biogerontology · 2025
- Lab dish studyThe Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
Stem cell reviews and reports · 2025
- Lab dish studyEpitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Biogerontology · 2025
- Lab dish studyShort Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.
International journal of molecular sciences · 2024
- Lab dish studyPeptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.
International journal of molecular sciences · 2022
- Lab dish studyShort Peptides Protect Oral Stem Cells from Ageing.
Stem cell reviews and reports · 2020
- Lab dish study[The influence of AEDG and KE peptides on mitochondries stain and L7A ribosomes protein expression during human pineal gland and thymus cell senescence in vitro.]
Advances in gerontology = Uspekhi gerontologii · 2020
- Lab dish study[GENOMIC VARIABILITY IN PATIENTS WITH DUCTAL FORM OF BREAST CANCER AND THE POSSIBILITY OF CORRECTION THE PEPTIDE BIOREGULATOR AND METAL IONS].
Georgian medical news · 2017
- Lab dish studyPenetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.
Biochemistry. Biokhimiia · 2011
- LCP2 mediates SUV39H1-driven cellular senescence-related chemoresistance in natural killer/T-cell lymphoma.
Cell death & disease · 2026
- EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON THE "OLD" CHROMATIN.
Georgian medical news · 2023
- [AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.]
Advances in gerontology = Uspekhi gerontologii · 2020
- AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.
Molecules (Basel, Switzerland) · 2020
- EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON "AGED" HETEROCHROMATIN.
Georgian medical news · 2020
- Effect of short peptides on neuronal differentiation of stem cells.
International journal of immunopathology and pharmacology · 2019
- Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum.
Biochemistry. Biokhimiia · 2017
- [Genome instability in pulmonary tuberculosis before and after treatment].
Georgian medical news · 2013
- [Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging].
Advances in gerontology = Uspekhi gerontologii · 2012
- Review of earlier workTherapeutic peptides in gerontology: mechanisms and applications for healthy aging.
Frontiers in aging · 2026
- Review of earlier workEpitalon and Epithalamin in Regenerative and Longevity Medicine: Mechanisms, Evidence, and Translational Gaps
2026
- Review of earlier workTherapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
- Review of earlier workFrom Cellular Aging to Tissue Protection: Epitalon in Regenerative and Longevity Medicine
2026
- Review of earlier workOverview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
International journal of molecular sciences · 2025
- Review of earlier work[Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.]
Advances in gerontology = Uspekhi gerontologii · 2024
- Review of earlier work[Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data].
Advances in gerontology = Uspekhi gerontologii · 2014
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What has happened so far
- 24 July 2026503A
FDA proposed that Epitalon NOT be included on the 503A Bulks List.
FDA briefing documentnot yet verified against primary source
- 16 April 2026503A
FDA published a Federal Register notice announcing a Pharmacy Compounding Advisory Committee meeting for July 23-24, 2026 at the White Oak campus, to consider seven peptides for the 503A Bulks List.
Federal Registernot yet verified against primary source