Epitalon
Very early researchThe research is at the earliest stage – mostly cells in a lab dish. It is far too early to say much.
Also called Epithalon / AEDG peptide / Ala-Glu-Asp-Gly
A four-part peptide studied in Russian ageing research. The work has not been repeated elsewhere and there is no approved use.
The basics
- What is it?
- A four-part lab-made peptide from Russian research on ageing.
- What do we know?
- Very little. A handful of Russian papers report effects on ageing markers.
- What do we still not know?
- Almost everything. Nobody outside those groups has repeated the work.
Can a doctor prescribe this?
No. Pharmacies are not on record as being allowed to make this into a medicine.
The FDA has not approved this as a medicine.
Not FDA approved and not on the 503A bulks list.
Official status: Not on the 503A bulks list. Checked 2026-03-30.
Lab suppliers we list: 16
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In animal studies
These are doses given to animals, usually per kilogram of body weight. They do not convert directly to a human dose.
See source wording
rats · nasal spray
Effects of intranasal administration of epitalon on neuron activity in the rat neocortex.Neuroscience and behavioral physiology · 2007
“Studies were performed using male Wistar rats anesthetized with urethane (1 g/kg).”
See source wording
rats · into a vein
[Intranasal epitalon infusion modulates neuronal activity in the rat neocortex].Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova · 2006
“Wistar male rats were anesthetized with urethane (1 g/kg).”
- [Protective effect of melatonin and epithalon on hypothalamic regulation of reproduction in female rats in its premature aging model and on estrous cycles in senescent animals in various lighting regimes].
Animal study, rats or mice
Advances in gerontology = Uspekhi gerontologii · 2013
- Melatonin and pineal gland peptides are able to correct the impairment of reproductive cycles in rats.
Animal study, rats or mice
Current aging science · 2012
- Effects of intranasal administration of epitalon on neuron activity in the rat neocortex.
Animal study, rats or mice
Neuroscience and behavioral physiology · 2007
- [Intranasal epitalon infusion modulates neuronal activity in the rat neocortex].
Animal study, rats or mice
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova · 2006
- Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.
Animal study, rats or mice
In vivo (Athens, Greece) · 2006
- [Effect of age, different light conditions, melatonin, and epitalon on lysosomal proteinase activity in the liver and kidneys of rats].
Animal study, rats or mice
Advances in gerontology = Uspekhi gerontologii · 2006
- Correction: Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Lab dish study
Biogerontology · 2025
- The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
Lab dish study
Stem cell reviews and reports · 2025
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Lab dish study
Journal not recorded · 2025
- Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development.
Lab dish study
Life sciences · 2025
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Lab dish study
Biogerontology · 2025
- Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.
Lab dish study
International journal of molecular sciences · 2024
- Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.
Lab dish study
International journal of molecular sciences · 2022
- Epitalon protects against post-ovulatory aging-related damage of mouse oocytes <i>in vitro</i>.
Lab dish study
Aging · 2022
- [The influence of AEDG and KE peptides on mitochondries stain and L7A ribosomes protein expression during human pineal gland and thymus cell senescence in vitro.]
Lab dish study
Advances in gerontology = Uspekhi gerontologii · 2020
- Short Peptides Protect Oral Stem Cells from Ageing.
Lab dish study
Stem cell reviews and reports · 2020
- LCP2 mediates SUV39H1-driven cellular senescence-related chemoresistance in natural killer/T-cell lymphoma.
Cell death & disease · 2026
- EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON THE "OLD" CHROMATIN.
Georgian medical news · 2023
- [AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.]
Advances in gerontology = Uspekhi gerontologii · 2020
- AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.
Molecules (Basel, Switzerland) · 2020
- Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum.
Biochemistry. Biokhimiia · 2017
- [Genome instability in pulmonary tuberculosis before and after treatment].
Georgian medical news · 2013
- Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.
Review of earlier work
Frontiers in aging · 2026
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
Review of earlier work
International journal of molecular sciences · 2025
- [Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.]
Review of earlier work
Advances in gerontology = Uspekhi gerontologii · 2024
- [Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data].
Review of earlier work
Advances in gerontology = Uspekhi gerontologii · 2014