Dulaglutide
Approved medicineGet notified when the evidence changes.
The FDA has approved a version of this as a medicine, so it has been through large studies in people.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-08-04
Also called Trulicity / LY2189265
An approved weekly injection for type 2 diabetes.
Official status: Not nominated for 503A compounding · Checked 2026-08-04
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Approved and prescription-only.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
This is a sample, not the whole literature.
About 18,000 papers mentioning this compound have been published. We show a selected sample of 56 of them, not the full literature. How we choose them · count checked 2026-08-23
- Study in peopleEffects of GLP-1 receptor agonists on copeptin in euvolemic participants.
European journal of endocrinology · 2026
- Study in peopleSafety and efficacy of switching from dulaglutide to tirzepatide across clinically relevant baseline characteristics in participants with T2D: subgroup analysis of SURPASS-SWITCH.
BMJ open diabetes research & care · 2026
- Study in peopleAdjunctive Dulaglutide in Relapsing-Remitting Multiple Sclerosis: A Randomized Open-Label Proof-of-Concept Trial.
Neurology and therapy · 2026
- Study in peopleDulaglutide vs insulin in adolescents with thalassaemia-induced diabetes: effect on metabolism and atherogenesis (DIADEMA).
Diabetologia · 2026
- Study in peopleInsulin Sensitivity and Beta Cell Function With Macupatide Alone or With Dulaglutide in Type 2 Diabetes: A Phase 1b, Randomised Controlled Trial.
Diabetes, obesity & metabolism · 2026
- Study in peopleDulaglutide and neurodegeneration biomarkers: REWIND post hoc analysis.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
- Study in peopleCardiorenal Outcomes With Tirzepatide Compared With Dulaglutide in Patients With Diabetes and Cardiovascular Disease: A Post Hoc Analysis of the SURPASS-CVOT Randomized Clinical Trial.
JAMA cardiology · 2026
- Study in peopleMazdutide versus dulaglutide in Chinese adults with type 2 diabetes.
Nature · 2026
- Study in peopleDulaglutide versus empagliflozin as add-on therapy to metformin and sulfonylurea in type 2 diabetes: a randomized pilot study with exploratory metabolomic and microbiome analyses.
Frontiers in endocrinology · 2026
- Study in peopleA comparison of the effects of tirzepatide and dulaglutide on major kidney events in people with type 2 diabetes: pre-specified exploratory analyses of the SURPASS-CVOT trial.
The lancet. Diabetes & endocrinology · 2026
- Study in peopleEfficacy and Safety of Dulaglutide Biosimilar LY05008 Versus the Reference Product Dulaglutide (Trulicity) in Chinese Adults With Type 2 Diabetes Mellitus: A Randomized, Open-Label, Active Comparator Study.
Journal of diabetes · 2025
- Study in peopleTreatment with orforglipron, an oral glucagon like peptide-1 receptor agonist, is associated with improvements of CV risk biomarkers in participants with type 2 diabetes or obesity without diabetes.
Cardiovascular diabetology · 2025
- Study in peopleBlood pressure changes during smoking cessation in a randomized, double-blind, placebo-controlled trial of dulaglutide treatment.
European journal of preventive cardiology · 2025
- Study in peopleOrforglipron, an oral non-peptide glucagon-like peptide-1 receptor agonist, improves markers of β-cell function and insulin sensitivity in type 2 diabetes.
Diabetes, obesity & metabolism · 2025
- Study in peopleEffects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial.
The lancet. Diabetes & endocrinology · 2025
- Study in peopleEfficacy and safety of cAMP-biased GLP-1 receptor agonist ecnoglutide versus dulaglutide in patients with type 2 diabetes and elevated glucose concentrations on metformin monotherapy (EECOH-2): a 52-week, multicentre, open-label, non-inferiority, randomised, phase 3 trial.
The lancet. Diabetes & endocrinology · 2025
- Study in peopleComparison of Dose Escalation Versus Switching to Tirzepatide Among People With Type 2 Diabetes Inadequately Controlled on Lower Doses of Dulaglutide : A Randomized Clinical Trial.
Annals of internal medicine · 2025
- Study in peopleAppetite, eating attitudes, and eating behaviours during treatment with retatrutide in adults with type 2 diabetes: Results of a phase 2 study.
Diabetes, obesity & metabolism · 2025
- Study in peopleComparative evaluation of dulaglutide alone vs. dulaglutide combined with probiotics on cardiovascular risk factors in T2DM.
Hormones (Athens, Greece) · 2025
- Study in peopleA pharmacokinetic study comparing the biosimilar HEC14028 and Dulaglutide (Trulicity®) in healthy Chinese subjects.
Clinical and translational science · 2024
- Study in peopleEffects of the glucagon-like peptide-1 receptor agonist dulaglutide on sexuality in healthy men: a randomised, double-blind, placebo-controlled crossover study.
EBioMedicine · 2024
- Study in peopleEffects of a Dulaglutide plus Calorie-Restricted Diet versus a Calorie-Restricted Diet on Visceral Fat and Metabolic Profiles in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial.
Nutrients · 2023
- Study in peopleDulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial.
Lancet (London, England) · 2019
- Study in peopleDulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial.
Lancet (London, England) · 2019
- Study in peopleEfficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial.
Lancet (London, England) · 2018
- Study in peopleSemaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial.
The lancet. Diabetes & endocrinology · 2018
- Study in peopleLY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept.
Molecular metabolism · 2018
- Study in peopleDulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial.
The lancet. Diabetes & endocrinology · 2018
- Study in peopleOnce-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial.
Lancet (London, England) · 2014
- Data from people, not a trialReal-world weight loss with injectable semaglutide vs dulaglutide for diabetes.
The American journal of managed care · 2026
- Data from people, not a trialDulaglutide-associated body odor with dechallenge and rechallenge in a patient with type 2 diabetes.
International journal of clinical pharmacology and therapeutics · 2026
- Data from people, not a trialA Pharmacovigilance Analysis of Ocular Adverse Events Associated with GLP-1 Receptor Agonists.
Journal of clinical medicine · 2026
- Data from people, not a trialPsychiatric and eye disorders associated with use of glucagon-like peptide 1 receptor agonists (GLP-1 RAs).
Naunyn-Schmiedeberg's archives of pharmacology · 2026
- Data from people, not a trialSwitching patterns of GLP-1 receptor agonists from 2018 to 2025 in the largest private healthcare network in Poland.
Acta diabetologica · 2026
- Data from people, not a trialGLP-1 agonist-associated presentations to unscheduled care: An opportunistic pilot study.
British journal of clinical pharmacology · 2026
- Data from people, not a trialDulaglutide Effect on Proteins Associated With CKD Progression.
Kidney international reports · 2026
- Data from people, not a trialClass-Wide Disproportionate Reporting of Impaired Gastric Emptying Across Nine Glucagon-Like Peptide-1 Receptor Agonist Products: A Signal-Detection Analysis of the FDA Adverse Event Reporting System
2026
- Data from people, not a trialCutaneous hypersensitivity reaction to dulaglutide: A case report of an allergic reaction.
Diabetes & metabolism · 2024
- Animal study, rats or miceContractile effects of dulaglutide in the human atrium.
Naunyn-Schmiedeberg's archives of pharmacology · 2026
- Animal study, rats or miceGlucagon-like peptide-1 receptor agonist dulaglutide attenuates liver injury in metabolic dysfunction-associated steatotic liver disease with diabetic mice.
European journal of pharmacology · 2026
- Lab dish studyProduction of a Dulaglutide Analogue by Apoptosis-Resistant Chinese Hamster Ovary Cells in a 3-Week Fed-Batch Process.
Pharmaceuticals (Basel, Switzerland) · 2025
- Lab dish studyDulaglutide and pregnancy: a comprehensive safety assessment using the <i>ex vivo</i> placenta perfusion and <i>in vitro</i> models.
Frontiers in pharmacology · 2025
- Lab test method, not a health studyMultiple analysis based on dual-mode anion-exchange chromatography strategy reveals significant impact of charge heterogeneity on structure and function of dulaglutide.
International journal of biological macromolecules · 2025
- Drug information page, not a studyDulaglutide
2006
- Unmasking the risk: euglycemic diabetic ketoacidosis induced by GLP-1 agonist in type 2 diabetes.
Proceedings (Baylor University. Medical Center) · 2026
- Comparison between liraglutide and dulaglutide on the incidence or progression of eye and kidney complications.
Journal of diabetes investigation · 2026
- Exit Interviews Examining Patient Experiences with Tirzepatide and Dulaglutide for Treatment of Type 2 Diabetes in the SURPASS-CVOT Trial.
Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026
- Effect of ketogenic diet plus dulaglutide on glucose and lipid metabolism in diabetes mellitus.
Pakistan journal of pharmaceutical sciences · 2025
- Association of bodyweight loss with changes in lipids, blood pressure, and fasting serum glucose following tirzepatide treatment in Japanese participants with type 2 diabetes: A post hoc analysis of the SURPASS J-mono trial.
Journal of diabetes investigation · 2025
- No abstract available, not yet classifiedAssessment of Changes in Body Composition After 3 Months of Dulaglutide Treatment [Response to Letter].
Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
- GLP-1 receptor agonists in the treatment of type 2 diabetes - state-of-the-art.
Molecular metabolism · 2021
- Review of earlier workComparative Efficacy and Safety of Tirzepatide Versus Dulaglutide in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Healthcare (Basel, Switzerland) · 2026
- Review of earlier workEstimating the True MACE Benefits From Tirzepatide in SURPASS-CVOT Using an Imputed Placebo Analysis of REWIND.
Diabetes care · 2026
- Review of earlier workComparison of Mazdutide and Dulaglutide for Type 2 Diabetes: a GRADE assessed systematic review and meta-analysis of randomized controlled trials
2026
- Review of earlier workGlucagon-Like Peptide-1 Receptor Agonists in Plastic Surgery: Perioperative Considerations and Safety Protocols.
Cureus · 2025
- Review of earlier workEfficacy and safety of dulaglutide compared with the first-line hypoglycemic drugs in Asian patients with type 2 diabetes: a systematic review and meta-analysis.
Scientific reports · 2022
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