DSIP
Animal studies onlyGet notified when the evidence changes.
Almost all the research is in animals. We do not know if the same thing happens in people.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-07-24
Also called Delta Sleep-Inducing Peptide / Emideltide
Named for its effect on deep sleep in rabbits. Human evidence is thin and inconsistent.
Official status: Declined for the 503A bulks list · Checked 2026-07-24
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
An FDA advisory panel voted against this one in July 2026, 6-7. It was the only rejection of the seven reviewed.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 6
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Study in peopleSingle-surface Intensive Phototherapy or Double-Surface Intensive Phototherapy in Neonatal Non-Hemolytic Hyperbilirubinemia: A Comparison of Effectiveness and Complications.
Medical journal of the Islamic Republic of Iran · 2021
- Study in peopleDelta sleep-inducing peptide alters bispectral index, the electroencephalogram and heart rate variability when used as an adjunct to isoflurane anaesthesia.
European journal of anaesthesiology · 2009
- Study in peopleEffects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study.
Neuropsychobiology · 1992
- Study in peopleReduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man.
Psychoneuroendocrinology · 1989
- Study in peopleStudy of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs.
International journal of clinical pharmacology research · 1987
- Study in peopleEffects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia.
European neurology · 1987
- Study in peopleEffects of DSIP in man. Multifunctional psychophysiological properties besides induction of natural sleep.
Neuropsychobiology · 1983
- Study in peopleAcute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior.
International journal of clinical pharmacology, therapy, and toxicology · 1981
- Study in peopleThe influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep.
Experientia · 1981
- Data from people, not a trialDSIP in insomnia.
European neurology · 1984
- Animal study, rats or mice<i>Pichia pastoris</i> secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models.
Frontiers in pharmacology · 2024
- Animal study, rats or miceDelta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke.
Molecules (Basel, Switzerland) · 2021
- Animal study, rats or miceDSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion.
Biomedicines · 2021
- Animal study, rats or micePhosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude.
Life sciences · 2018
- Animal study, rats or miceExpression and Purification of Delta Sleep-Inducing Peptide Fused with Protein Transduction Domain and Human Serum Albumin in Pichia pastoris.
Protein and peptide letters · 2017
- Animal study, rats or mice[THE INFLUENCE OF DELTA SLEEP-INDUCING PEPTIDE ON FUNCTIONAL STATE OF RATS HEPATOCYTES IN FOOT-SHOCK STRESS].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova · 2015
- Animal study, rats or mice[Influence of delta-sleep inducing peptide on the state of lysosomal membranes and intensity of lysosomal proteolysis in different rat tissues during physiological aging of the organism].
Advances in gerontology = Uspekhi gerontologii · 2014
- Animal study, rats or mice[Influence of delta-sleep peptide on the enzymes activity of mitochondrial electron transport chain in various rat tissues during aging of the organism].
Advances in gerontology = Uspekhi gerontologii · 2014
- Animal study, rats or mice[Effects of the δ-sleep inducing peptide on neuronal activity in the dorsal hippocampus of rats with different behavior in the open field after stimulation of the positive and negative emotionalistic structures of the brain].
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova · 2013
- Animal study, rats or mice[Metabolic effects of delta-sleep inducing peptide during physiological aging of the organism].
Eksperimental'naia i klinicheskaia farmakologiia · 2013
- Animal study, rats or miceDizocilpine and cycloheximide prevent inhibition of c-Fos gene expression by delta sleep-inducing peptide in the paraventricular nucleus of the hypothalamus in rats with different resistance to emotional stress.
Neuroscience letters · 2012
- Animal study, rats or mice[Effect of delta-sleep inducing peptide on the functional activity of some organs and tissues of rats during physiological aging].
Advances in gerontology = Uspekhi gerontologii · 2012
- Animal study, rats or mice[Mechanism of delta-sleep inducing peptide geroprotective activity].
Advances in gerontology = Uspekhi gerontologii · 2011
- Animal study, rats or mice[Changes in duodenal lymphoid structures in rats with various behavioral activity, caused by delta sleep-inducing peptide and following acute emotional stress].
Morfologiia (Saint Petersburg, Russia) · 2010
- Lab dish study[Antioxidative and detoxifying effects of analogues of delta-sleep inducing peptide (DSIP)].
Bioorganicheskaia khimiia · 2014
- Lab dish study[Delta-sleep inducing peptide entrapment and release from polymer hydrogels based on modified polyvinyl alcohol in vitro].
Biomeditsinskaia khimiia · 2013
- Lab dish studyDelta-sleep-inducing peptide does not affect CRH and meal-induced ACTH and cortisol secretion.
Psychoneuroendocrinology · 1995
- Lab test method, not a health studyProtein isoaspartate methyltransferase-mediated 18O-labeling of isoaspartic acid for mass spectrometry analysis.
Analytical chemistry · 2012
- Hypothesis, not a tested studyDomain-specific information preservation for Alzheimer's disease diagnosis with incomplete multi-modality neuroimages.
Medical image analysis · 2025
- Chemistry or materials paper, not a health studyPractical N-to-C peptide synthesis with minimal protecting groups.
Communications chemistry · 2023
- Chemistry or materials paper, not a health studyProtecting Group-Minimum, Practical N-to-C Peptide Synthesis
2023
- A federated policy-governed architecture for sovereign European data spaces
2026
- Sensing the Bactericidal and Bacteriostatic Antimicrobial Mode of Action Using Raman Deuterium Stable Isotope Probing (DSIP) in <i>Escherichia coli</i>.
ACS omega · 2024
- Sensing the bactericidal and bacteriostatic antimicrobial mode of action using Raman-Deuterium stable isotope probing (DSIP)
2024
- An RCT study on the feasibility of anterior transpedicular screw fixation in the cervicothoracic junction.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2016
- Delta-sleep inducing peptide entrapment in the charged macroporous matrices.
Materials science & engineering. C, Materials for biological applications · 2014
- [Using deltalicin for the treatment of patients with diabetic retinopathy].
Eksperimental'naia i klinicheskaia farmakologiia · 2014
- [Olygopeptide KND as a putative endogenous prototype of delta sleep inducing peptide (DSIP). Comparative study of biological properties].
Bioorganicheskaia khimiia · 2013
- JmjC-domain-containing histone demethylases of the JMJD1B type as putative precursors of endogenous DSIP.
Peptides · 2011
- No abstract available, not yet classifiedOpioid detoxification with delta sleep-inducing peptide: results of an open clinical trial.
Journal of clinical psychopharmacology · 1998
- Different effects of delta-sleep-inducing peptide on arginine-vasopressin and ACTH secretion in normal men.
Hormone research · 1994
- Plasma concentration of nine hormones and neurotransmitters during usual activities or constant bed rest for 34 H.
Chronobiology international · 1994
- Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women.
Psychoneuroendocrinology · 1993
- A clinical trial with DSIP.
European neurology · 1984
- No abstract available, not yet classifiedSynthetic delta-sleep-inducing peptide improves sleep in insomniacs.
Lancet (London, England) · 1981
- Review of earlier workTherapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
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