DSIP

In animal studies

These are doses given to animals, usually per kilogram of body weight. They do not convert directly to a human dose.

• 120 mcg/kg

  rats · nasal spray · for 7 days

  Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke.Molecules (Basel, Switzerland) · 2021

  “DSIP or vehicle was applied nasally 60 (±15) minutes prior to the occlusion and for 7 days after reperfusion at dose 120 µg/kg.”

• See source wording

  rats · daily

  Phosphorylated delta sleep inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitude.Life sciences · 2018

  “p-DSIP was injected intra-peritoneally (10 μg/Kg bw) during HH exposure as an intervention against sleep alteration.”

• 2 mg/kg

  mice · under the skin

  Expression and Purification of Delta Sleep-Inducing Peptide Fused with Protein Transduction Domain and Human Serum Albumin in Pichia pastoris.Protein and peptide letters · 2017

  “Mice were administered single subcutaneous injections three concentrations of PHD fusion protein (0.5, 1, 2 mg/kg), and the pharmacological activity of PHD fusion protein was studied using classic pentobarbitalinduced sleep test.”

• See source wording

  rats · another route

  [THE INFLUENCE OF DELTA SLEEP-INDUCING PEPTIDE ON FUNCTIONAL STATE OF RATS HEPATOCYTES IN FOOT-SHOCK STRESS].Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova · 2015

  “The effect of delta sleep-inducing peptide (DSIP) intraperitoneal injection in the doses of 40, 120, 360, and 1080 mcg/kg b.”

• 100 mcg/kg

  rats · under the skin

  [Influence of delta-sleep inducing peptide on the state of lysosomal membranes and intensity of lysosomal proteolysis in different rat tissues during physiological aging of the organism].Advances in gerontology = Uspekhi gerontologii · 2014

  “It is shown that subcutaneous injection of exogenous delta-sleep inducing peptide (DSIP) to rats aged 2-24 months in a dose of 100 μg/kg animal body weight by courses of 5 consecutive days per month has a stabilizing effect on the state of lysosomal membranes in rat tissues (brain, heart muscle and liver) at different ontogenetic stages, and this effect is accompanied by increasing intensity of lysosomal proteolysis in these tissues.”

• 100 mcg/kg

  rats · under the skin

  [Influence of delta-sleep peptide on the enzymes activity of mitochondrial electron transport chain in various rat tissues during aging of the organism].Advances in gerontology = Uspekhi gerontologii · 2014

  “It is shown that subcutaneous injection of exogenous delta-sleep inducing peptide (DSIP) to rats aged 2-24 months in a dose of 100 μg/kg animal body weight by courses of 5 consecutive days per month has a stabilizing effect on the NADH-dehydrogenase activity in the mitochondrial fractions of various tissues, which together with increasing capacity of the antioxidant system should reduce the production of free radicals and their adverse action on cells macromolecule, herewith the activity of succinate dehydrogenase did not change.”

• 100 g

  rats · under the skin

  [Metabolic effects of delta-sleep inducing peptide during physiological aging of the organism].Eksperimental'naia i klinicheskaia farmakologiia · 2013

  “Subcutaneous injection of delta-sleep inducing peptide (DSIP) to postnatal rats (aged from 2 to 24 months) during 5 consecutive days every months at a dose of 10 microg/100 g body weight favors normalization of the age-related changes in carbohydrate metabolism and shows hypoglycemic effect, as manifested by a decrease in the level of glycosylated hemoglobin in erythrocytes of test rats.”

• See source wording

  rats · another route

  Dizocilpine and cycloheximide prevent inhibition of c-Fos gene expression by delta sleep-inducing peptide in the paraventricular nucleus of the hypothalamus in rats with different resistance to emotional stress.Neuroscience letters · 2012

  “The experiments show that intraperitoneal (i.p.) DSIP injection (60 nmol/kg) decreased the number of Fos-immunoreactive (Fos-IR) cells in the pPVN, activated by immobilization.”

• 100 mg/kg

  rats · under the skin

  [Effect of delta-sleep inducing peptide on the functional activity of some organs and tissues of rats during physiological aging].Advances in gerontology = Uspekhi gerontologii · 2012

  “The authors show that exogenous delta-sleep inducing peptide (DSIP) injected subcutaneously to the rats in the age of 2-24 months of postnatal development in a dose of 100 mg/kg of animal body weight in courses for 5 consecutive days every month, has a hepatoprotective effect.”

• 100 g

  rats · under the skin

  [Mechanism of delta-sleep inducing peptide geroprotective activity].Advances in gerontology = Uspekhi gerontologii · 2011

  “It is shown that the subcutaneous injection to the rats in the age from 2 to 24 months during 5 consecutive days every month with 10 microg/100 g body weight of delta-sleep inducing peptide (DSIP) suppresses lipid peroxidation preventing the increasing of malonic dialdehyde level in rats tissues and plasma, possesses a powerful antioxidant effect, which is realized by means of the activation of different endogenous antioxidant defense system of cell and extracellular fluid, including high- and low-molecular regulators of free radical processes.”