Dihexa
Animal studies onlyAlmost all the research is in animals. We do not know if the same thing happens in people.
Also called N-hexanoic-Tyr-Ile-(6) aminohexanoic amide / PNB-0408
Studied in rats for building new connections between brain cells. No human data.
Can a doctor prescribe this?
No. It sits on a restricted list, so pharmacies are not allowed to make it.
The FDA has not approved this as a medicine.
Still restricted. The FDA has said it plans to review this one by February 2027.
Official status: Category 2 – restricted from compounding. Checked 2026-04-15.
Lab suppliers we list: 5
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In animal studies
These are doses given to animals, usually per kilogram of body weight. They do not convert directly to a human dose.
See source wording
rats ·
Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies.Annals of medicine and surgery (2012) · 2021
“Bone marrow derived syngeneic MSCs (2 × 10 6 ; passage≤6), G-CSF (200-400 μg/kg b.wt.), Dihexa (2-4 mg/kg b.wt.) and/or Vehicle were administered to male Lewis rats locally via hydrogel at the site of nerve repair, systemically (i.v./i.p), and/or to gastrocnemius muscle.”
- Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats.
Animal study, rats or mice
Journal of Huntington's disease · 2024
- AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway.
Animal study, rats or mice
Brain sciences · 2021
- Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies.
Animal study, rats or mice
Annals of medicine and surgery (2012) · 2021
- Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents.
Animal study, rats or mice
The Journal of pharmacology and experimental therapeutics · 2013
- Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy.
Lab dish study
Stem cell research & therapy · 2022
- Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy
Lab dish study
Journal not recorded · 2021
- Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells.
Lab dish study
Current protocols in stem cell biology · 2016
- Dimeric DOTA-alpha-melanocyte-stimulating hormone analogs: synthesis and in vivo characteristics of radiopeptides with high in vitro activity.
Lab dish study
Journal of receptor and signal transduction research · 2007
- Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure.
Frontiers in cellular neuroscience · 2015
- The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system.
The Journal of pharmacology and experimental therapeutics · 2014
- Phase segregation of polymerizable lipids to construct filters for separating lipid-membrane-embedded species.
Biomicrofluidics · 2014
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Review of earlier work
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
- Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies.
Review of earlier work
Neuroscience and biobehavioral reviews · 2018
- The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease.
Review of earlier work
Journal of Alzheimer's disease : JAD · 2015
- The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases.
Review of earlier work
Progress in neurobiology · 2015