Dihexa
Animal studies onlyGet notified when the evidence changes.
Almost all the research is in animals. We do not know if the same thing happens in people.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-04-15
Also called N-hexanoic-Tyr-Ile-(6) aminohexanoic amide / PNB-0408
Studied in rats for building new connections between brain cells. No human data.
Official status: 503A Category 2 – significant safety risk · Checked 2026-04-15
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Still restricted. The FDA has said it plans to review this one by February 2027.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 5
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Animal study, rats or miceEffects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats.
Journal of Huntington's disease · 2024
- Animal study, rats or miceAngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway.
Brain sciences · 2021
- Animal study, rats or miceStem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies.
Annals of medicine and surgery (2012) · 2021
- Animal study, rats or miceEvaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents.
The Journal of pharmacology and experimental therapeutics · 2013
- Studied in worms or fishHepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure.
Frontiers in cellular neuroscience · 2015
- Lab dish studyEfficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy.
Stem cell research & therapy · 2022
- Lab dish studySmall-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells.
Current protocols in stem cell biology · 2016
- Lab dish studyDimeric DOTA-alpha-melanocyte-stimulating hormone analogs: synthesis and in vivo characteristics of radiopeptides with high in vitro activity.
Journal of receptor and signal transduction research · 2007
- Chemistry or materials paper, not a health studyPhase segregation of polymerizable lipids to construct filters for separating lipid-membrane-embedded species.
Biomicrofluidics · 2014
- The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system.
The Journal of pharmacology and experimental therapeutics · 2014
- Review of earlier workTherapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
- Review of earlier workCognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies.
Neuroscience and biobehavioral reviews · 2018
- Review of earlier workThe Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease.
Journal of Alzheimer's disease : JAD · 2015
- Review of earlier workThe development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases.
Progress in neurobiology · 2015
Spot an error? corrections@peptidesearch.org