Dermorphin

In animal studies

These are doses given to animals, usually per kilogram of body weight. They do not convert directly to a human dose.

• 10 mg/kg

  rats · under the skin

  Dermorphin [D-Arg2, Lys4] (1-4) Amide Attenuates Burn Pain by Inhibiting TRPV1/NR2B Mediated Neuroinflammatory Signalling.Molecular neurobiology · 2025

  “Systemic administration of DALDA significantly reduced evoked pain behaviour in a dose-dependent manner (1, 3, and 10 mg/kg), with the 10 mg/kg s.c.”

• 5 mg

  rats ·

  Characterizing a new rat model of chronic pain after spine surgery.Bone research · 2025

  “Administration of Dermorphin [D-Arg2, Lys4] (1-4) amide (DALDA, 5 mg /kg, i.p.), a peripherally acting mu-opioid receptor (MOR)-preferred agonist, attenuated pain hypersensitivity, capsaicin-induced [Ca 2+ ]i rising and the increased intrinsic excitability of DRG neurons from CPSS rats.”

• See source wording

  rats ·

  Dermorphin [D-Arg2, Lys4] (1-4) Amide Alleviates Frostbite-Induced Pain by Regulating TRP Channel-Mediated Microglial Activation and Neuroinflammation.Molecular neurobiology · 2024

  “Animals with frostbite injury displayed significant hypersensitivity to mechanical, thermal, and cold stimuli which was significant ameliorated on treatment with different doses of DALDA (1, 3, and 10 mg/kg) and ibuprofen (100 mg/kg).”

• 2.5 ng

  horses ·

  A high throughput approach for determination of dermorphin in human urine using liquid chromatography-mass spectrometry for doping control purposes.Journal of mass spectrometry : JMS · 2020

  “The limit of detection for initial testing procedure and the limit of identification for confirmation procedure was 2.5 ng/ml.”

• See source wording

  rats · by mouth

  The Neurotropic Activity of Novel Dermorphin Analogs Active at Systemic and Noninvasive Administration.International journal of molecular sciences · 2025

  “A smaller dose of 0.5 µg/kg resulted in 40% analgesia and a short-term state of stupor.”

• See source wording

  mice ·

  In vitro and in vivo pharmaco-dynamic study of the novel fentanyl derivatives: Acrylfentanyl, Ocfentanyl and Furanylfentanyl.Neuropharmacology · 2022

  “In vivo, we investigated the acute effects of the systemic administration of ACRYLF, OCF and FUF (0.01-15 mg/kg i.p.) on mechanical and thermal analgesia, motor impairment, grip strength and cardiorespiratory changes in CD-1 male mice.”