Chrysalin
Tested in peopleGet notified when the evidence changes.
It has been tested in people, but it is not an approved medicine. The studies are usually small.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-08-04
Also called TP-508 / Rusalatide acetate
A short peptide copied from thrombin, tested in people for bone and wound healing.
The basics
- What is it?
- Chrysalin is a 23-amino-acid piece of thrombin, a blood clotting protein. It has been through human trials for fracture repair and diabetic foot ulcers.
Official status: Not nominated for 503A compounding · Checked 2026-08-04
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Not FDA approved and not on the U.S. compounding list. A doctor cannot prescribe it.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 2
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Study in peopleThrombin peptide Chrysalin stimulates healing of diabetic foot ulcers in a placebo-controlled phase I/II study.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2007
- Animal study, rats or miceRadiomitigation and Tissue Repair Activity of Systemically Administered Therapeutic Peptide TP508 Is Enhanced by PEGylation.
The AAPS journal · 2017
- Animal study, rats or miceAcceleration of consolidation period by thrombin peptide 508 in tibial distraction osteogenesis in rats.
The British journal of oral & maxillofacial surgery · 2010
- Animal study, larger animalsEffect of thrombin fragment (TP508) on myocardial ischemia reperfusion injury in a model of type 1 diabetes mellitus.
Circulation · 2010
- Animal study, larger animalsEffect of dimerized thrombin fragment TP508 on acute myocardial ischemia reperfusion injury in hypercholesterolemic swine.
The Journal of pharmacology and experimental therapeutics · 2010
- Animal study, larger animalsEvaluation of early osteochondral defect repair in a rabbit model utilizing fourier transform-infrared imaging spectroscopy, magnetic resonance imaging, and quantitative T2 mapping.
Tissue engineering. Part C, Methods · 2010
- Animal study, larger animalsEffect of thrombin fragment (TP508) on myocardial ischemia-reperfusion injury in hypercholesterolemic pigs.
Journal of applied physiology (Bethesda, Md. : 1985) · 2009
- Animal study, larger animalsThrombin fragment (TP508) decreases myocardial infarction and apoptosis after ischemia reperfusion injury.
The Annals of thoracic surgery · 2009
- Animal study, rats or miceThrombin peptide TP508 prevents nitric oxide mediated apoptosis in chondrocytes in the endochondral developmental pathway.
Biochimica et biophysica acta · 2008
- Animal study, larger animalsLocal injection of thrombin-related peptide (TP508) in PPF/PLGA microparticles-enhanced bone formation during distraction osteogenesis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2008
- Animal study, larger animalsTP508 (Chrysalin) reverses endothelial dysfunction and increases perfusion and myocardial function in hearts with chronic ischemia.
Journal of cardiovascular pharmacology and therapeutics · 2008
- Animal study, rats or miceTP508 accelerates fracture repair by promoting cell growth over cell death.
Biochemical and biophysical research communications · 2007
- Animal study, rats or miceThrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2005
- Animal study, rats or miceThrombin peptide (TP508) treatment of rat growth plate cartilage cells promotes proliferation and retention of the chondrocytic phenotype while blocking terminal endochondral differentiation.
Journal of cellular physiology · 2005
- Animal study, larger animalsBone formation is enhanced by thrombin-related peptide TP508 during distraction osteogenesis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2005
- Animal study, larger animalsRepair of rabbit segmental defects with the thrombin peptide, TP508.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2004
- Studied in worms or fishGateways to clinical trials.
Methods and findings in experimental and clinical pharmacology · 2007
- Lab dish studyNuclear Countermeasure Activity of TP508 Linked to Restoration of Endothelial Function and Acceleration of DNA Repair.
Radiation research · 2016
- Lab dish studySystemic administration of thrombin peptide TP508 enhances VEGF-stimulated angiogenesis and attenuates effects of chronic hypoxia.
Journal of vascular research · 2013
- Lab dish studyThrombin peptide TP508 stimulates cellular events leading to angiogenesis, revascularization, and repair of dermal and musculoskeletal tissues.
The Journal of bone and joint surgery. American volume · 2006
- Lab dish studyOn the mode of action of thrombin-induced angiogenesis: thrombin peptide, TP508, mediates effects in endothelial cells via alphavbeta3 integrin.
Thrombosis and haemostasis · 2004
- Hypothesis, not a tested studyTechnology evaluation: Chrysalin (Orthologic).
Current opinion in molecular therapeutics · 2005
- Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity.
Laboratory investigation; a journal of technical methods and pathology · 2015
- Cooperative effects in differentiation and proliferation between PDGF-BB and matrix derived synthetic peptides in human osteoblasts.
BMC musculoskeletal disorders · 2011
- Thrombin peptide TP508 stimulates rapid nitric oxide production in human endothelial cells.
Journal of vascular research · 2010
- Thrombin peptide (TP508) promotes adipose tissue-derived stem cell proliferation via PI3 kinase/Akt pathway.
Journal of vascular research · 2009
- Could rusalatide acetate be the future drug of choice for diabetic foot ulcers and fracture repair?
Expert opinion on pharmacotherapy · 2008
- rhBMP-2, rhVEGF(165), rhPTN and thrombin-related peptide, TP508 induce chemotaxis of human osteoblasts and microvascular endothelial cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2005
- Blood pumps: technologies and markets in transformation.
Artificial organs · 2001
- Review of earlier workIn-silico evaluation of Oroxylum indicum vent compounds in the plausible treatment and prevention of nasopharyngeal cancer.
Journal of Ayurveda and integrative medicine · 2024
- Review of earlier workThe Role of Recombinant Proteins and Growth Factors in the Management of Diabetic Foot Ulcers: A Systematic Review of Randomized Controlled Trials.
Journal of diabetes research · 2020
Spot an error? corrections@peptidesearch.org