Cerebrolysin
Tested in peopleGet notified when the evidence changes.
It has been tested in people, but it is not an approved medicine. The studies are usually small.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-08-04
Also called FPF-1070 / EVER Neuro Pharma
A mixture of pig-brain-derived peptides. Approved in several countries but not the US.
Official status: Not nominated for 503A compounding · Checked 2026-08-04
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Approved in some countries outside the US. Not FDA-approved and not on the compounding list.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Study in peopleNeuroprotective Effects of Cerebrolysin in Moderate Traumatic Brain Injury with Nonoperative Lesions: A 6-Month Prospective Cohort Analysis.
Asian journal of neurosurgery · 2026
- Study in peopleSpeech Therapy Combined With Cerebrolysin in Enhancing Nonfluent Aphasia Recovery After Acute Ischemic Stroke: ESCAS Randomized Pilot Study.
Stroke · 2025
- Study in peopleCerebrolysin ameliorates ketamine-mediated anxiety and cognitive impairments via modulation of mitochondrial function and CREB/PGC-1α pathway.
Molecular brain · 2025
- Study in peopleCerebrolysin, hemorrhagic transformation, and anticoagulation timing after reperfusion therapy in stroke: <i>post hoc</i> secondary analysis of the CEREHETIS trial.
Frontiers in pharmacology · 2025
- Study in peopleCerebrolysin, Hemorrhagic Transformation, and Anticoagulation Timing after Reperfusion Therapy in Stroke: Secondary Analysis of the CEREHETIS Trial
2025
- Study in peopleSafety and feasibility of cerebrolysin in treatment of primary intracerebral hemorrhage (CLINCH)-a prospective, randomized, open-label, blinded endpoint pilot trial.
Frontiers in neurology · 2025
- Study in people[Cerebrolysin with reperfusion therapy in ischemic stroke: a prospective analysis of multimodal brain imaging data from the CEREHETIS trial].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2025
- Study in peopleEfficacy of Cerebrolysin Treatment as an Add-On Therapy to Mechanical Thrombectomy in Patients with Acute Ischemic Stroke Due to Large Vessel Occlusion in Anterior Circulation: Results of a 3-Month Follow-up of a Prospective, Open Label, Single-Center Study.
Translational stroke research · 2025
- Study in people[Cerebrolysin and the optimal timing of anticoagulation resumption in stroke: combined post hoc survival analysis of the CEREHETIS trial].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2025
- Study in people[Cerebrolysin in the preventive therapy of dementia in elderly patients with mild cognitive impairment: a three-year prospective comparative study].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2024
- Study in peopleExtended Poststroke Rehabilitation Combined with Cerebrolysin Promotes Upper Limb Motor Recovery in Early Subacute Phase of Rehabilitation: A Randomized Clinical Study.
Medicina (Kaunas, Lithuania) · 2023
- Study in peopleThe effectiveness of cerebrolysin, a multi-modal neurotrophic factor, for treatment of post-covid-19 persistent olfactory, gustatory and trigeminal chemosensory dysfunctions: a randomized clinical trial.
Expert review of clinical pharmacology · 2023
- Study in peopleCerebrolysin as an Early Add-on to Reperfusion Therapy: Risk of Hemorrhagic Transformation after Ischemic Stroke (CEREHETIS), a prospective, randomized, multicenter pilot study.
BMC neurology · 2023
- Study in people[Effects of simultaneous use of Cerebrolysin and alteplase on hemorrhagic transformation of brain infarction and functional outcome in stroke patients: CEREHETIS, a randomized, multicenter pilot trial].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2023
- Study in peopleProspective Randomized Control Trial to Compare the Role of Injection Cerebrolysin for 10 Days Duration Against Placebo in Operated Cases of Degenerative Cervical Myelopathy.
Spine · 2023
- Study in peopleAdd-on treatment with Cerebrolysin improves clinical symptoms in patients with ALS: results from a prospective, single-center, placebo-controlled, randomized, double-blind, phase II study.
Journal of medicine and life · 2023
- Study in peopleModulation of Amyloid-β and Tau in Alzheimer's Disease Plasma Neuronal-Derived Extracellular Vesicles by Cerebrolysin® and Donepezil.
Journal of Alzheimer's disease : JAD · 2022
- Study in peopleProspective Randomized Control Pilot Study to Compare the Role of Injection Cerebrolysin in Operated cases of Degenerative Cervical Myelopathy.
Spine · 2022
- Study in peopleEfficacy and safety of Cerebrolysin after futile recanalisation therapy in patients with severe stroke.
Clinical neurology and neurosurgery · 2021
- Study in peopleSafety and efficacy of Cerebrolysin in acute brain injury and neurorecovery: CAPTAIN I-a randomized, placebo-controlled, double-blind, Asian-Pacific trial.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
- Study in peopleEfficacy and safety of cerebrolysin in neurorecovery after moderate-severe traumatic brain injury: results from the CAPTAIN II trial.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
- Study in peopleRandomized, placebo-controlled, double-blind, pilot trial to investigate safety and efficacy of Cerebrolysin in patients with aneurysmal subarachnoid hemorrhage.
BMC neurology · 2020
- Study in peopleEfficacy and safety of Cerebrolysin treatment in early recovery after acute ischemic stroke: a randomized, placebo-controlled, double-blinded, multicenter clinical trial.
Journal of medicine and life · 2017
- Study in peopleCerebrolysin and early neurorehabilitation in patients with acute ischemic stroke: a prospective, randomized, placebo-controlled clinical study.
Journal of medicine and life · 2017
- Study in peopleDemonstration of therapeutic window of Cerebrolysin in embolic stroke: A prospective, randomized, blinded, and placebo-controlled study.
International journal of stroke : official journal of the International Stroke Society · 2017
- Study in peopleEffect of cerebrolysin on gross motor function of children with cerebral palsy: a clinical trial.
Acta neurologica Belgica · 2017
- Study in peopleCerebrolysin combined with rehabilitation promotes motor recovery in patients with severe motor impairment after stroke.
BMC neurology · 2016
- Study in people[Comparative dynamics of EEG parameters in elderly depressive patients during monotherapy and combined therapy].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2016
- Study in peopleCerebrolysin and Recovery After Stroke (CARS): A Randomized, Placebo-Controlled, Double-Blind, Multicenter Trial.
Stroke · 2016
- Study in people[Effect of cerebrolysin on remyelination processes in multiple sclerosis patients in stage of relapse regression].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2016
- Study in people[An impact of neuroprotective therapy on blood rheological and morphodensitometric parameters in patients with chronic cerebral ischemia].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2014
- Study in peopleCerebrolysin enhances cognitive recovery of mild traumatic brain injury patients: double-blind, placebo-controlled, randomized study.
British journal of neurosurgery · 2013
- Study in peopleA prospective, randomized, placebo-controlled, double-blind trial about safety and efficacy of combined treatment with alteplase (rt-PA) and Cerebrolysin in acute ischaemic hemispheric stroke.
International journal of stroke : official journal of the International Stroke Society · 2013
- Study in peopleCerebrolysin in patients with acute ischemic stroke in Asia: results of a double-blind, placebo-controlled randomized trial.
Stroke · 2012
- Study in peopleTherapeutic effects of cerebrolysin added to risperidone in patients with schizophrenia dominated by negative symptoms.
The Australian and New Zealand journal of psychiatry · 2012
- Study in peopleCombination treatment in Alzheimer's disease: results of a randomized, controlled trial with cerebrolysin and donepezil.
Current Alzheimer research · 2011
- Study in peopleCerebrolysin in vascular dementia: improvement of clinical outcome in a randomized, double-blind, placebo-controlled multicenter trial.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2011
- Study in peopleEfficacy and safety of Cerebrolysin in moderate to moderately severe Alzheimer's disease: results of a randomized, double-blind, controlled trial investigating three dosages of Cerebrolysin.
European journal of neurology · 2011
- Study in peopleCerebrolysin adjuvant treatment in Broca's aphasics following first acute ischemic stroke of the left middle cerebral artery.
Journal of medicine and life · 2010
- Study in peoplePersistence of the effects of Cerebrolysin on cognition and qEEG slowing in vascular dementia patients: results of a 3-month extension study.
Journal of the neurological sciences · 2010
- Study in people[The effect of cerebrolysin in dosage 50 ml on the volume of lesion in ischemic stroke].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2010
- Study in peopleEfficacy and safety of Cerebrolysin in patients with hemorrhagic stroke.
Journal of medicine and life · 2010
- Study in peopleReduced TNF-α and increased IGF-I levels in the serum of Alzheimer's disease patients treated with the neurotrophic agent cerebrolysin.
The international journal of neuropsychopharmacology · 2009
- Study in peopleA double-blind, placebo-controlled, randomized trial to evaluate the safety and efficacy of Cerebrolysin in patients with acute ischaemic stroke in Asia--CASTA.
International journal of stroke : official journal of the International Stroke Society · 2009
- Study in peopleA pilot study to evaluate the effects of Cerebrolysin on cognition and qEEG in vascular dementia: cognitive improvement correlates with qEEG acceleration.
Journal of the neurological sciences · 2008
- Study in peopleA 24-week, double-blind, placebo-controlled study of three dosages of Cerebrolysin in patients with mild to moderate Alzheimer's disease.
European journal of neurology · 2006
- Study in peopleNeuroprotective treatment with cerebrolysin in patients with acute stroke: a randomised controlled trial.
Journal of neural transmission (Vienna, Austria : 1996) · 2005
- Study in peopleEffects of N-PEP-12 on memory among older adults.
International clinical psychopharmacology · 2005
- Study in people[A randomized, double-blind, placebo-controlled study of Cerebrolysin safety and efficacy in the treatment of acute ischemic stroke].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2004
- Study in peopleCerebrolysin in Alzheimer's disease: a randomized, double-blind, placebo-controlled trial with a neurotrophic agent.
Journal of neural transmission (Vienna, Austria : 1996) · 2002
- Study in peopleImproved global function and activities of daily living in patients with AD: a placebo-controlled clinical study with the neurotrophic agent Cerebrolysin.
Journal of neural transmission. Supplementum · 2002
- Study in peopleSustained improvement of cognition and global function in patients with moderately severe Alzheimer's disease: a double-blind, placebo-controlled study with the neurotrophic agent Cerebrolysin.
Journal of neural transmission. Supplementum · 2002
- Study in peopleA 28-week, double-blind, placebo-controlled study with Cerebrolysin in patients with mild to moderate Alzheimer's disease.
International clinical psychopharmacology · 2001
- Study in peopleA double-blind, placebo-controlled, multicenter study of Cerebrolysin for Alzheimer's disease.
Journal of the American Geriatrics Society · 2000
- Study in peopleEfficacy of the peptidergic nootropic drug cerebrolysin in patients with senile dementia of the Alzheimer type (SDAT).
Pharmacopsychiatry · 1994
- Study in peopleA multidimensional approach in testing nootropic drug effects (Cerebrolysin).
Archives of gerontology and geriatrics · 1990
- Data from people, not a trialCerebrolysin after Endovascular Thrombectomy in Stroke: 12‑Month Functional Outcomes in a Propensity‑Matched Cohort.
Translational stroke research · 2026
- Data from people, not a trialResearch-Evidence-Practice Gaps in Post-stroke Neuro-recovery Pharmacological Therapies in Asia.
Cerebrovascular diseases extra · 2026
- Data from people, not a trialPredictors of Psychoactive and Nootropic Substance Use Among Romanian University Healthcare Students: The Interplay Between Academic Anxiety and Educational Advancement.
Healthcare (Basel, Switzerland) · 2026
- Data from people, not a trialCerebrolysin as an adjunct to speech-language therapy in post-stroke Wernicke's aphasia: a case report.
Journal of medicine and life · 2026
- Data from people, not a trialAdjunctive Cerebrolysin therapy following mechanical thrombectomy for acute basilar artery occlusion: a case report.
Journal of medicine and life · 2026
- Data from people, not a trialVery Early Short-Course Cerebrolysin After Tenecteplase and Mechanical Thrombectomy: A Case Report.
Case reports in neurological medicine · 2026
- Data from people, not a trialImprovement of aphasia deficits following traumatic intracranial hemorrhage: a case report.
Journal of medicine and life · 2026
- Data from people, not a trialC-REGS2-A multinational, high-quality comparative effectiveness study of Cerebrolysin in moderate acute ischemic stroke.
International journal of stroke : official journal of the International Stroke Society · 2025
- Data from people, not a trialCombined citicoline and Cerebrolysin for neuroprotection in traumatic brain injury: a retrospective cohort analysis.
Frontiers in neurology · 2025
- Data from people, not a trialCerebrolysin treatment in a case of post-herpes simplex encephalitis with neuropsychiatric symptoms.
Journal of medicine and life · 2025
- Data from people, not a trialEvaluating the Effect of Cerebrolysin as an Adjuvant to Standard Therapy in Patients with Acute Ischemic Stroke: A Prospective Observational Study.
Medicina (Kaunas, Lithuania) · 2025
- Data from people, not a trialA Real-World Data Analysis of Adverse Drug Reactions Associated with Neuroprotective Agents: Insights from WHO-VigiAccess
2025
- Data from people, not a trialSurgical excision of cerebral glioma and multimodal treatment including Cerebrolysin: a case report.
Journal of medicine and life · 2025
- Data from people, not a trialBeneficial effect of cerebrolysin on moderate and severe head injury patients: result of a cohort study.
Acta neurochirurgica. Supplement · 2005
- Animal study, rats or mice[The effect of neuroprotectors on the level of BDNF, tumor necrosis factor alpha and apoptosis markers, and in acute cerebrovascular accidents].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2026
- Animal study, rats or miceThe Role of Cerebrolysin in Promoting Axonal Regeneration and Functional Recovery after Peripheral Nerve Injury: A Focus on Macrophage Activation.
Advanced pharmaceutical bulletin · 2025
- Animal study, rats or miceCerebrolysin Ameliorates Age-Induced Dendritic Spine Degeneration and Memory Decline in C57BL6 Mice.
Neurochemical research · 2025
- Animal study, larger animalsCerebrolysin for acute ischaemic stroke.
The Cochrane database of systematic reviews · 2023
- Animal study, rats or miceCerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke.
Journal of neuroscience research · 2010
- Lab dish studyExosomes Released by Cerebrolysin-Treated Cerebral Endothelial Cells Reverse Fibrin- or tPA-Impaired Endothelial Cell Permeability.
Cells · 2026
- Lab dish studyBiochemical and Pharmacological Studies on Kynurenic Acid Metabolism in the <i>Helix pomatia</i>-Snail Model of Learning and Memory.
Biomolecules · 2026
- Lab dish studyBiochemical and Pharmacological Studies in the <em>Helix pomatia</em>—Snail Memory Model
2025
- Lab dish studyA Neurofilament-L reporter cell line for the quantification of early neuronal differentiation: A Bioassay for neurotrophic activities.
Heliyon · 2024
- Lab dish studySonic hedgehog signaling pathway mediates cerebrolysin-improved neurological function after stroke.
Stroke · 2013
- Hypothesis, not a tested studyUse of nootropics in Alzheimer's disease: An analysis of regulatory positions and drug policies in the countries of the Commonwealth of Independent States.
The International journal of risk & safety in medicine · 2026
- [Experience of using of Cerebrolysin in comprehensive rehabilitation of a patient after ischemic stroke with motor deficit and aphasia].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2026
- [Therapy prospects for post-stroke aphasia].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2026
- No abstract available, not yet classifiedCerebrolysin and Risk of Hemorrhagic Transformation: A Pooled Analysis of Recent Studies.
Journal of clinical neurology (Seoul, Korea) · 2026
- Cost-effectiveness of Cerebrolysin as an add-on treatment for neurorecovery after traumatic brain injury.
Journal of medicine and life · 2025
- Influence of Exogenous Neuropeptides on the Astrocyte Response Under Conditions of Continuous and Cyclic Hypoxia and Red Blood Cell Lysate.
International journal of molecular sciences · 2025
- No abstract available, not yet classifiedLeft atrial occlusion in intracerebral hemorrhage with atrial fibrillation, herpes zoster, and stroke, improving stroke outcomes in China, and Cerebrolysin as a treatment for acute stroke.
International journal of stroke : official journal of the International Stroke Society · 2025
- Effect of cerebrolysin on neurodevelopmental outcome of high risk preterm infants: A randomized controlled trial.
Journal of neonatal-perinatal medicine · 2022
- The Effect of Cerebrolysin on the Predictive Value of Baseline Prognostic Risk Score in Moderate and Severe Traumatic Brain Injury.
Journal of medicine and life · 2020
- Role of Cerebrolysin in cervical spondylotic myelopathy patients: a prospective randomized study.
The spine journal : official journal of the North American Spine Society · 2018
- [Monitoring of neurotrophic factors and cognitive function in patients with traumatic brain injury].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2017
- [An assessment of cerebrolysin effect on BDNF level in patients with post stroke aphasia depending on carbohydrate metabolism disorders].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2015
- [Cerebrolysin in the treatment of brain injuries of moderate severity].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2014
- [Neuroprotective treatment of chronic cerebrovascular insufficiency].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2014
- [Comparative aspects of using neuroprotectors in the management of patients with ischemic stroke].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2011
- [Efficiency of cerebrolysin in the diabetic polyneuropathy in patients with insulin-dependency diabetes mellitus].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2011
- [Electrophysiological correlates of efficacy of nootropic drugs in the treatment of consequences of traumatic brain injury in adolescents].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2010
- Reductions in qEEG slowing over 1 year and after treatment with Cerebrolysin in patients with moderate-severe traumatic brain injury.
Journal of neural transmission (Vienna, Austria : 1996) · 2008
- Positive effects of cerebrolysin on electroencephalogram slowing, cognition and clinical outcome in patients with postacute traumatic brain injury: an exploratory study.
International clinical psychopharmacology · 2003
- Cerebrolysin therapy in Rett syndrome: clinical and EEG mapping study.
Brain & development · 2001
- Review of earlier workEfficacy and Safety of Cerebrolysin as an Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Observational Studies.
Brain and behavior · 2026
- Review of earlier work[The effect of Cerebrolysin on the development of skills in patients after acute cerebrovascular accidents].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2026
- Review of earlier workCerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026
- Review of earlier workAn Adaptive, Time-Informed, Phenotype-Guided Pharmacological Framework for Severe Traumatic Brain Injury : A Hypothesis-Driven Narrative Review.
Journal of Korean Neurosurgical Society · 2026
- Review of earlier workPost-endovascular thrombectomy perfusion imaging (CT and MR) as a prognostic biomarker and patient-selection tool for adjuvant therapy: A systematic review, meta-analysis, and clinical threshold framework.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026
- Review of earlier workSafety and Efficacy of Cerebrolysin for Neurorecovery After Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of 14 Randomized Controlled Trials.
Cureus · 2025
- Review of earlier workIs Cerebrolysin Useful in Psychiatry Disorders?
Biomedicines · 2025
- Retracted or withdrawn, not evidenceRetraction: Regional Comparison of the Neurogenic Effects of CNTF-Derived Peptides and Cerebrolysin in AβPP Transgenic Mice.
Journal of Alzheimer's disease : JAD · 2026
- Retracted or withdrawn, not evidenceEditorial Expression of Concern: Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin.
Acta neuropathologica · 2026
- Retracted or withdrawn, not evidenceRetraction Note to: Timed Release of Cerebrolysin Using Drug-Loaded Titanate Nanospheres Reduces Brain Pathology and Improves Behavioral Functions in Parkinson's Disease.
Molecular neurobiology · 2026
- Retracted or withdrawn, not evidenceRetraction Note: Cerebrolysin Attenuates Exacerbation of Neuropathic Pain, Blood-Spinal Cord Barrier Breakdown and Cord Pathology Following Chronic Intoxication of Engineered Ag, Cu or Al (50-60 nm) Nanoparticles.
Neurochemical research · 2026
- Retracted or withdrawn, not evidenceRetraction Note: Neurotrophic effects of Cerebrolysin in the Mecp2<sup>308/Y</sup> transgenic model of Rett syndrome.
Acta neuropathologica · 2026
- Retracted or withdrawn, not evidenceRetraction Note: Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure.
BMC neuroscience · 2025
- Retracted or withdrawn, not evidenceRetraction Note: Neuroprotective effects of Cerebrolysin in triple repeat Tau transgenic model of Pick's disease and fronto-temporal tauopathies.
BMC neuroscience · 2025
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