Cerebrolysin
Tested in peopleIt has been tested in people, but it is not an approved medicine. The studies are usually small.
Also called FPF-1070 / EVER Neuro Pharma
A mixture of pig-brain-derived peptides. Approved in several countries but not the US.
Can a doctor prescribe this?
No. Pharmacies are not on record as being allowed to make this into a medicine.
The FDA has not approved this as a medicine.
Approved in some countries outside the US. Not FDA-approved and not on the compounding list.
Official status: Not on the 503A bulks list. Checked 2026-08-04.
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
In human trials
See source wording
into a vein · once daily · for 14 days
Combined Cerebrolysin and Amantadine Sulfate Administration for Patients With Traumatic Brain Injury in the ICUPHASE3 · NCT06052787
“* Temperature management: to maintain normothermia * Glycemic control: to maintain a glucose level of \[140 -180 mg/dl\] * Peptic ulcer prophylaxis: * Deep venous thrombosis (DVT) prophylaxis.”
See source wording
by mouth · weekly
Cerebrolysin Compared to Donepezil in Patients With Mild to Moderate Dementia of Alzheimer's Type (DAT)PHASE4 · NCT01822951
“5-10 mg donepezil: 1x5 mg donepezil as 1 tablet per day from TC 1 Day 1 on and 2x5 mg donepezil as 2 tablets from Visit 3- Visit 5, p.o.”
See source wording
into a vein · daily
Comparative Study to Test Safety and Efficacy of Neurotrophic and Cholinergic Treatment of Alzheimer's DiseasePHASE2 · NCT00911807
“After four weeks the daily dosage was increased from 5 mg to 10 mg..”
215.2 mg
into a muscle · once daily · for 8 weeks
Cerebrolycin for Treatment of Covid-related Anosmia and AgeusiaPHASE3 · NCT04830943
“Cerebrolysin will be prescribed in a dose of 5 ml ampoule once daily through intramuscular injection (1ml contains 215.2 mg cerebrolysin) for five times per week, for a total of 40 treatments (for 8 weeks), after which the cycle was individually repeated according to the response of the patient to therapy for a maximum of 24 weeks.”
See source wording
by mouth · once daily · for 5 days
Efficacy of Prednisolone Versus Cerebrolysin in the Treatment of Bell's PalsyPHASE1, PHASE2 · NCT05821075
“prednisolone 60mg tablet once daily for 5 days then tapering dose.”
25 mg
into a vein · twice daily · for 10 days
Dl-3-n-butylphthalide and Cerebrolysin Treatment in Acute Ischemic StrokePHASE1, PHASE2 · NCT02149875
“Intravenous infusion of 25mg dl-3-n-butylphthalide b.i.d.for 10 days.”
In animal studies
See source wording
rats · into a vein
[The effect of neuroprotectors on the level of BDNF, tumor necrosis factor alpha and apoptosis markers, and in acute cerebrovascular accidents].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2026
“At the onset of reperfusion, animals were administered a single intravenous injection of either saline (control), or Mexidol (ethylmethylhydroxypyridine succinate) intravenously at a dose of 50 mg/kg, or Cerebrolysin intraperitoneally at a dose of 215 mg/kg, or Cortexin intraperitoneally at a dose of 1 mg/kg.”
20 mg/kg
mice · another route · once daily
Cerebrolysin ameliorates ketamine-mediated anxiety and cognitive impairments via modulation of mitochondrial function and CREB/PGC-1α pathway.Molecular brain · 2025
“Intraperitoneal injection of ketamine was performed at 20 mg/kg for 14 consecutive days.”
See source wording
rats ·
The Role of Cerebrolysin in Promoting Axonal Regeneration and Functional Recovery after Peripheral Nerve Injury: A Focus on Macrophage Activation.Advanced pharmaceutical bulletin · 2025
“Results Results demonstrated that Cerebrolysin, particularly at 5 mg/kg, significantly improved SFI scores and thermal paw withdrawal latency compared to the control group, indicating enhanced functional recovery.”
- Neuroprotective Effects of Cerebrolysin in Moderate Traumatic Brain Injury with Nonoperative Lesions: A 6-Month Prospective Cohort Analysis.
Study in people
Asian journal of neurosurgery · 2026
- Cerebrolysin after Endovascular Thrombectomy in Stroke: 12‑Month Functional Outcomes in a Propensity‑Matched Cohort.
Study in people
Translational stroke research · 2026
- C-REGS2-A multinational, high-quality comparative effectiveness study of Cerebrolysin in moderate acute ischemic stroke.
Study in people
International journal of stroke : official journal of the International Stroke Society · 2025
- Speech Therapy Combined With Cerebrolysin in Enhancing Nonfluent Aphasia Recovery After Acute Ischemic Stroke: ESCAS Randomized Pilot Study.
Study in people
Stroke · 2025
- Safety and feasibility of cerebrolysin in treatment of primary intracerebral hemorrhage (CLINCH)-a prospective, randomized, open-label, blinded endpoint pilot trial.
Study in people
Frontiers in neurology · 2025
- Add-on treatment with Cerebrolysin improves clinical symptoms in patients with ALS: results from a prospective, single-center, placebo-controlled, randomized, double-blind, phase II study.
Study in people
Journal of medicine and life · 2023
- Retraction: Regional Comparison of the Neurogenic Effects of CNTF-Derived Peptides and Cerebrolysin in AβPP Transgenic Mice.
Animal study, rats or mice
Journal of Alzheimer's disease : JAD · 2026
- [The effect of neuroprotectors on the level of BDNF, tumor necrosis factor alpha and apoptosis markers, and in acute cerebrovascular accidents].
Animal study, rats or mice
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2026
- Editorial Expression of Concern: Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin.
Animal study, rats or mice
Acta neuropathologica · 2026
- Cerebrolysin ameliorates ketamine-mediated anxiety and cognitive impairments via modulation of mitochondrial function and CREB/PGC-1α pathway.
Animal study, rats or mice
Molecular brain · 2025
- The Role of Cerebrolysin in Promoting Axonal Regeneration and Functional Recovery after Peripheral Nerve Injury: A Focus on Macrophage Activation.
Animal study, rats or mice
Advanced pharmaceutical bulletin · 2025
- Cerebrolysin Ameliorates Age-Induced Dendritic Spine Degeneration and Memory Decline in C57BL6 Mice.
Animal study, rats or mice
Neurochemical research · 2025
- Exosomes Released by Cerebrolysin-Treated Cerebral Endothelial Cells Reverse Fibrin- or tPA-Impaired Endothelial Cell Permeability.
Lab dish study
Cells · 2026
- Biochemical and Pharmacological Studies on Kynurenic Acid Metabolism in the <i>Helix pomatia</i>-Snail Model of Learning and Memory.
Lab dish study
Biomolecules · 2026
- Biochemical and Pharmacological Studies in the <em>Helix pomatia</em>—Snail Memory Model
Lab dish study
Journal not recorded · 2025
- A Neurofilament-L reporter cell line for the quantification of early neuronal differentiation: A Bioassay for neurotrophic activities.
Lab dish study
Heliyon · 2024
- Cerebrolysin and Risk of Hemorrhagic Transformation: A Pooled Analysis of Recent Studies.
Journal of clinical neurology (Seoul, Korea) · 2026
- Retraction Note: Cerebrolysin Attenuates Exacerbation of Neuropathic Pain, Blood-Spinal Cord Barrier Breakdown and Cord Pathology Following Chronic Intoxication of Engineered Ag, Cu or Al (50-60 nm) Nanoparticles.
Neurochemical research · 2026
- Research-Evidence-Practice Gaps in Post-stroke Neuro-recovery Pharmacological Therapies in Asia.
Cerebrovascular diseases extra · 2026
- [Experience of using of Cerebrolysin in comprehensive rehabilitation of a patient after ischemic stroke with motor deficit and aphasia].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2026
- [Therapy prospects for post-stroke aphasia].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2026
- Retraction Note: Neurotrophic effects of Cerebrolysin in the Mecp2<sup>308/Y</sup> transgenic model of Rett syndrome.
Acta neuropathologica · 2026
- Use of nootropics in Alzheimer's disease: An analysis of regulatory positions and drug policies in the countries of the Commonwealth of Independent States.
The International journal of risk & safety in medicine · 2026
- Predictors of Psychoactive and Nootropic Substance Use Among Romanian University Healthcare Students: The Interplay Between Academic Anxiety and Educational Advancement.
Healthcare (Basel, Switzerland) · 2026
- Retraction Note to: Timed Release of Cerebrolysin Using Drug-Loaded Titanate Nanospheres Reduces Brain Pathology and Improves Behavioral Functions in Parkinson's Disease.
Molecular neurobiology · 2026
- Retraction Note: Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure.
BMC neuroscience · 2025
- Retraction Note: Neuroprotective effects of Cerebrolysin in triple repeat Tau transgenic model of Pick's disease and fronto-temporal tauopathies.
BMC neuroscience · 2025
- Cost-effectiveness of Cerebrolysin as an add-on treatment for neurorecovery after traumatic brain injury.
Journal of medicine and life · 2025
- Cerebrolysin, hemorrhagic transformation, and anticoagulation timing after reperfusion therapy in stroke: <i>post hoc</i> secondary analysis of the CEREHETIS trial.
Frontiers in pharmacology · 2025
- Influence of Exogenous Neuropeptides on the Astrocyte Response Under Conditions of Continuous and Cyclic Hypoxia and Red Blood Cell Lysate.
International journal of molecular sciences · 2025
- Combined citicoline and Cerebrolysin for neuroprotection in traumatic brain injury: a retrospective cohort analysis.
Frontiers in neurology · 2025
- Surgical excision of cerebral glioma and multimodal treatment including Cerebrolysin: a case report.
Journal of medicine and life · 2025
- Cerebrolysin, Hemorrhagic Transformation, and Anticoagulation Timing after Reperfusion Therapy in Stroke: Secondary Analysis of the CEREHETIS Trial
Journal not recorded · 2025
- Cerebrolysin treatment in a case of post-herpes simplex encephalitis with neuropsychiatric symptoms.
Journal of medicine and life · 2025
- Evaluating the Effect of Cerebrolysin as an Adjuvant to Standard Therapy in Patients with Acute Ischemic Stroke: A Prospective Observational Study.
Medicina (Kaunas, Lithuania) · 2025
- A Real-World Data Analysis of Adverse Drug Reactions Associated with Neuroprotective Agents: Insights from WHO-VigiAccess
Journal not recorded · 2025
- Left atrial occlusion in intracerebral hemorrhage with atrial fibrillation, herpes zoster, and stroke, improving stroke outcomes in China, and Cerebrolysin as a treatment for acute stroke.
International journal of stroke : official journal of the International Stroke Society · 2025
- Cerebrolysin for acute ischaemic stroke.
The Cochrane database of systematic reviews · 2023
- Efficacy and Safety of Cerebrolysin as an Adjunct to Mechanical Thrombectomy in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Observational Studies.
Review of earlier work
Brain and behavior · 2026
- [The effect of Cerebrolysin on the development of skills in patients after acute cerebrovascular accidents].
Review of earlier work
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2026
- Cerebroprotection in acute ischemic stroke: Perspectives on combining cerebrolysin with recanalization therapy.
Review of earlier work
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026
- Safety and Efficacy of Cerebrolysin for Neurorecovery After Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of 14 Randomized Controlled Trials.
Review of earlier work
Cureus · 2025
- Is Cerebrolysin Useful in Psychiatry Disorders?
Review of earlier work
Biomedicines · 2025
- Microglial Polarization and Therapeutic Strategies in Post-stroke Neuroinflammation.
Review of earlier work
Neurology and therapy · 2025