Cartalax
Animal studies onlyGet notified when the evidence changes.
Almost all the research is in animals. We do not know if the same thing happens in people.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-08-04
Also called Ala-Glu-Asp-Gly
A four-part peptide from Russian research, studied in animals for cartilage and joints.
Official status: Not nominated for 503A compounding · Checked 2026-08-04
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Not FDA approved and not on the U.S. compounding list. A doctor cannot prescribe it.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 5
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Animal study, rats or miceMelatonin and pineal gland peptides are able to correct the impairment of reproductive cycles in rats.
Current aging science · 2012
- Animal study, rats or mice[The influence of melatonin and epithalon on blood leukocyte count and leukocyte alkaline phosphatase in rats under different lighting conditions during ontogenesis].
Advances in gerontology = Uspekhi gerontologii · 2008
- Animal study, rats or miceComparative analysis of the expression of c-Fos and interleukin-2 proteins in hypothalamus cells during various treatments.
Neuroscience and behavioral physiology · 2008
- Animal study, rats or miceGeroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens.
Bulletin of experimental biology and medicine · 2008
- Animal study, rats or miceEffects of intranasal administration of epitalon on neuron activity in the rat neocortex.
Neuroscience and behavioral physiology · 2007
- Animal study, rats or miceAntioxidant properties of geroprotective peptides of the pineal gland.
Archives of gerontology and geriatrics · 2007
- Animal study, rats or miceEffect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.
Bulletin of experimental biology and medicine · 2007
- Animal study, rats or mice[Intranasal epitalon infusion modulates neuronal activity in the rat neocortex].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova · 2006
- Animal study, rats or miceEffect of a synthetic pineal tetrapeptide (Ala-Glu-Asp-GLy) on melatonin secretion by the pineal gland of young and old rats.
Journal of endocrinological investigation · 2003
- Animal study, rats or micePineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.
Neuro endocrinology letters · 2002
- Studied in worms or fishEffect of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the morphology of the thymus in hypophysectomized young and old birds.
Bulletin of experimental biology and medicine · 2013
- Studied in worms or fish[Effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds].
Advances in gerontology = Uspekhi gerontologii · 2011
- Studied in worms or fishEffects of peptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on hormonal activity and structure of the thyroid gland in hypophysectomized young chickens and old hens.
Bulletin of experimental biology and medicine · 2011
- Studied in worms or fish[Effects of hypophyseal Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly synthetic peptides on immunity, hemostasis, morphology and functions of the thyroid gland in neonatally hypophysectomized chicken and one-year-old birds].
Patologicheskaia fiziologiia i eksperimental'naia terapiia · 2010
- Studied in worms or fish[Effects of epithalon and cortagene on immunity and hemostasis in neonatally hypophysectomized chicken and old birds].
Advances in gerontology = Uspekhi gerontologii · 2008
- Studied in worms or fishEffect of tetrapeptides Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly on the structure and function of the thyroid gland in neonatally hypophysectomized chickens.
Bulletin of experimental biology and medicine · 2008
- Lab dish studyThe Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.
Stem cell reviews and reports · 2025
- Lab dish studyShort Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes.
International journal of molecular sciences · 2024
- Lab dish study[GENOMIC VARIABILITY IN PATIENTS WITH DUCTAL FORM OF BREAST CANCER AND THE POSSIBILITY OF CORRECTION THE PEPTIDE BIOREGULATOR AND METAL IONS].
Georgian medical news · 2017
- Lab dish studyPenetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.
Biochemistry. Biokhimiia · 2011
- Lab dish studyEffect of short peptides on expression of signaling molecules in organotypic pineal cell culture.
Bulletin of experimental biology and medicine · 2011
- Hypothesis, not a tested study[Adhesion molecule JAM-A, its function and mechanism of epigenetic regulation].
Advances in gerontology = Uspekhi gerontologii · 2015
- EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON THE "OLD" CHROMATIN.
Georgian medical news · 2023
- AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.
Molecules (Basel, Switzerland) · 2020
- EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON "AGED" HETEROCHROMATIN.
Georgian medical news · 2020
- [AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.]
Advances in gerontology = Uspekhi gerontologii · 2020
- Effect of short peptides on neuronal differentiation of stem cells.
International journal of immunopathology and pharmacology · 2019
- Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum.
Biochemistry. Biokhimiia · 2017
- Short Peptides and Telomere Length Regulator Hormone Irisin.
Bulletin of experimental biology and medicine · 2016
- Short cell-penetrating peptides: a model of interactions with gene promoter sites.
Bulletin of experimental biology and medicine · 2013
- Interaction of short peptides with FITC-labeled wheat histones and their complexes with deoxyribooligonucleotides.
Biochemistry. Biokhimiia · 2013
- [Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging].
Advances in gerontology = Uspekhi gerontologii · 2012
- Melting of DNA double strand after binding to geroprotective tetrapeptide.
Bulletin of experimental biology and medicine · 2008
- Molecular mechanism of interaction between oligopeptides and double-stranded DNA.
Bulletin of experimental biology and medicine · 2006
- Review of earlier workEpitalon and Epithalamin in Regenerative and Longevity Medicine: Mechanisms, Evidence, and Translational Gaps
2026
- Review of earlier workOverview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
International journal of molecular sciences · 2025
- Review of earlier work[The Role of Cytokines MIC-1/GDF15 in Development of the Old Age Disease].
Uspekhi fiziologicheskikh nauk · 2015
- Review of earlier work[Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data].
Advances in gerontology = Uspekhi gerontologii · 2014
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