Cagrilintide
Tested in peopleGet notified when the evidence changes.
It has been tested in people, but it is not an approved medicine. The studies are usually small.
Compiled and reviewed by the PeptideSearch Editorial Team · Status checked 2026-08-04
Also called AM833 / NNC0174-0833
Copies a hunger hormone called amylin. Being tested alongside semaglutide as a combination called CagriSema.
Official status: Not nominated for 503A compounding · Checked 2026-08-04
Can a doctor prescribe this?
- Small pharmacy (503A)
- Never put forward to FDA
- Large outsourcing facility (503B)
- Never put forward to FDA
Investigational. Not approved and not legal to compound.
503A is a pharmacy making a single prescription for one patient. 503B is a facility making batches. They are governed by separate lists. Where a category is shown, it is a position on the FDA's list of substances that have been put forward and are still being worked through — not the final list, which is set by rulemaking. Category 1 means the FDA does not plan to act against a pharmacy that makes it while the review runs.
Lab suppliers we list: 8
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
- Study in peopleEfficacy and safety of once-weekly cagrilintide-semaglutide (CagriSema) in adults with type 2 diabetes inadequately controlled on diet and exercise (REIMAGINE 1): a randomised, double-blind, placebo-controlled, phase 3a study.
The lancet. Diabetes & endocrinology · 2026
- Study in peopleCagrilintide-semaglutide (CagriSema) as an add-on to basal insulin in adults with type 2 diabetes (REIMAGINE 3): a randomised, double-blind, placebo-controlled, multicentre, phase 3 study.
Lancet (London, England) · 2026
- Study in peopleRenal or Hepatic Impairment Does Not Affect Pharmacokinetics, Safety, or Tolerability of Subcutaneous Cagrilintide.
Clinical pharmacokinetics · 2026
- Study in peopleCagrilintide-semaglutide (CagriSema) versus semaglutide or cagrilintide in people with type 2 diabetes (REIMAGINE 2): a double-blind, randomised, controlled, phase 3 study.
The lancet. Diabetes & endocrinology · 2026
- Study in peopleEfficacy and safety of co-administered cagrilintide and semaglutide versus semaglutide alone in adults with overweight or obesity with or without type 2 diabetes in Japan and Taiwan (REDEFINE 5): a multicentre, randomised, active-controlled, phase 3a trial.
The lancet. Diabetes & endocrinology · 2026
- Study in peopleEfficacy and safety of zalfermin co-administered with semaglutide in participants with fibrosis and cirrhosis due to metabolic dysfunction-associated steatohepatitis: a phase 2, dose-ranging, double-blind, randomised controlled trial.
The lancet. Gastroenterology & hepatology · 2026
- Study in peopleCagriSema Reduces Blood Pressure in Adults With Overweight or Obesity: REDEFINE 1.
Hypertension (Dallas, Tex. : 1979) · 2026
- Study in peopleEloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept.
Molecular metabolism · 2025
- Study in peopleCagrilintide-Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes.
The New England journal of medicine · 2025
- Study in peopleCoadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity.
The New England journal of medicine · 2025
- Study in peopleCagrilintide is not associated with clinically relevant QTc prolongation: A thorough QT study in healthy participants.
Diabetes, obesity & metabolism · 2024
- Study in peopleEfficacy and safety of co-administered once-weekly cagrilintide 2·4 mg with once-weekly semaglutide 2·4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial.
Lancet (London, England) · 2023
- Study in peopleOnce-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial.
Lancet (London, England) · 2021
- Study in peopleSafety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2·4 mg for weight management: a randomised, controlled, phase 1b trial.
Lancet (London, England) · 2021
- Data from people, not a trialCharacterization of 0839 - A tool compound for pre-clinical mode-of-action studies of amylin analogues such as cagrilintide.
Life sciences · 2025
- Animal study, rats or miceA cross-species atlas of the dorsal vagal complex reveals neural mediators of the effects of cagrilintide on energy balance.
Nature metabolism · 2026
- Animal study, rats or miceLong-acting amylin-related peptides as therapies for obesity and type 2 diabetes.
Peptides · 2026
- Animal study, rats or miceCagrilintide and retatrutide combination therapy enhances weight loss and metabolic outcomes in obese male rats.
Nature metabolism · 2026
- Animal study, rats or miceCagrilintide lowers bodyweight through brain amylin receptors 1 and 3.
EBioMedicine · 2025
- Animal study, rats or miceAM833 Is a Novel Agonist of Calcitonin Family G Protein-Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists.
The Journal of pharmacology and experimental therapeutics · 2021
- Lab test method, not a health studyIn vitro metabolic profiling of weight-loss-inducing amylin receptor agonists in the context of preventive doping research.
Journal of pharmaceutical and biomedical analysis · 2026
- Ease of Use, Ease of Learning, and Convenience of the CagriSema Dual-Chamber Pen: Results From a Usability Study in Adults With Overweight, Obesity, or Type 2 Diabetes.
Journal of diabetes science and technology · 2026
- Co-agonism of GLP-1R and CTR/AMYR in the lateral dorsal tegmental nucleus produces additive effects on homeostatic and motivated feeding.
Physiology & behavior · 2026
- No abstract available, not yet classifiedCagrilintide-semaglutide: a new option for patients with type 2 diabetes.
The lancet. Diabetes & endocrinology · 2026
- Mitochondrial Adaptations in Skeletal Muscle Following Incretin-Based Therapies: In Vitro.
Journal of cachexia, sarcopenia and muscle · 2026
- Efficacy of CagriSema for Reaching Anthropometric Treatment Targets and Cardiometabolic Outcomes: A Secondary, Post hoc Analysis of REDEFINE 1.
Diabetes, obesity & metabolism · 2026
- Structural and mechanistic insights into dual activation of cagrilintide in amylin and calcitonin receptors.
Acta pharmacologica Sinica · 2026
- No abstract available, not yet classifiedCellular loci for cagrilintide action identified.
Nature metabolism · 2026
- In adults with overweight or obesity, weekly subcutaneous cagrilintide-semaglutide increased weight loss at 68 wk.
Annals of internal medicine · 2025
- No abstract available, not yet classifiedCagrilintide-Semaglutide in Adults with Overweight or Obesity.
The New England journal of medicine · 2025
- Development of Cagrilintide, a Long-Acting Amylin Analogue.
Journal of medicinal chemistry · 2021
- Review of earlier workComparative Effectiveness of CagriSegma, Semaglutide, Cagrilintide and Tirzepatide in the Management of Overweight and Obesity: A Network Meta-Analysis of Randomized Clinical Trials.
Endocrinology, diabetes & metabolism · 2026
- Review of earlier workCagrilintide and CagriSema for weight reduction and metabolic risk modification in overweight or obesity: a systematic review and meta-analysis.
Journal of diabetes and metabolic disorders · 2026
- Review of earlier workComparative efficacy and safety of glucagon-like peptide 1 based drugs for weight loss in adults with overweight or obesity without diabetes: network meta-analysis of randomised controlled trials.
BMJ medicine · 2026
- Review of earlier workAmylin Analogs: The Next Major Class of Weight Loss Therapy: A Review of Experimental Data and Early-Phase Clinical Trials.
Diabetes, obesity & metabolism · 2026
- Review of earlier workEfficacy and Safety of Cagrilintide and Cagrisema Versus Semaglutide as Anti-Obesity Medications: A Systematic Review, Meta-Analysis and Meta-Regression.
Diabetes, obesity & metabolism · 2026
- Review of earlier workEfficacy and Safety of Glucagon-like Peptide-1 Receptor Agonists and Co-agonists for Weight Loss Among Adults Without Diabetes : An Updated Systematic Review.
Annals of internal medicine · 2026
- Review of earlier workAmylin Revisited: A 5-Year Perspective on Its Emerging Role in the Treatment of Diabesity.
Journal of obesity & metabolic syndrome · 2026
- Review of earlier workBeyond GLP-1: Amylin-based pharmacotherapy and the search for better-tolerated weight-loss drugs.
Pharmacological research · 2026
- Review of earlier workMaximizing weight loss with cagrisema: a systematic review and GRADE-assessed meta-analysis of randomized controlled trials.
Naunyn-Schmiedeberg's archives of pharmacology · 2026
- Review of earlier workAmylin-based obesity therapy: a meta-analysis of Cagrilintide and CagriSema versus placebo.
Annals of medicine and surgery (2012) · 2026
- Review of earlier workEfficacy and Safety of CagriSema for Metabolic Outcomes: Systematic Review and Pairwise Meta-Analysis of Randomized Controlled Trials.
Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
- Review of earlier workCagrilintide–Semaglutide Combination Therapy Versus Monotherapy or Placebo: A Systematic Review and Meta-Analysis
2025
- Review of earlier workSynthetic target trial emulation and predictive modeling of amylin-pathway therapies for obesity and type 2 diabetes.
Metabolism open · 2025
- Review of earlier workEfficacy and Safety of Cagrilintide Alone and in Combination with Semaglutide (Cagrisema) as Anti-Obesity Medications: A Systematic Review and Meta-Analysis.
Indian journal of endocrinology and metabolism · 2024
- Review of earlier workAmylin as a Future Obesity Treatment.
Journal of obesity & metabolic syndrome · 2021
Spot an error? corrections@peptidesearch.org