Argireline
Tested in peopleIt has been tested in people, but it is not an approved medicine. The studies are usually small.
Also called Acetyl Hexapeptide-8 / Acetyl Hexapeptide-3 / AH8
A skincare ingredient marketed as a topical alternative to Botox. Sold in cosmetics, not prescribed.
Can a doctor prescribe this?
No. Pharmacies are not on record as being allowed to make this into a medicine.
The FDA has not approved this as a medicine.
Sold as a cosmetic ingredient, which is regulated differently from drugs.
Official status: Not on the 503A bulks list. Checked 2026-08-04.
Lab suppliers we list: 3
Doses used in research
Taken word for word from the studies and trials listed on this page. This is not a recommendation and not a dose for anyone to take.
No dosing information has been published in the research indexed here.
- Investigating the effects of Argireline in a skin serum containing hyaluronic acids on skin surface wrinkles using the Visia<sup>®</sup> Complexion Analysis camera system for objective skin analysis.
Study in people
GMS Interdisciplinary plastic and reconstructive surgery DGPW · 2023
- Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy.
Study in people
European journal of neurology · 2013
- Ex Vivo Evaluation of Skin Permeability Enhancement Using TargetCool in Human-Derived Skin Tissue Models.
Lab dish study
The Journal of craniofacial surgery · 2026
- DES-mediated self-assembled polypeptides: Synergistic neuromuscular signaling inhibition for anti-aging.
Lab dish study
Biomaterials advances · 2026
- Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients.
Lab dish study
International journal of biological macromolecules · 2026
- A Supramolecular System of Bioactive Ionic Liquid, Peony Extract, and Peptide for Enhanced Permeability and Synergistic Skincare Benefits.
Lab dish study
Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
- Dual-function supramolecular system of α-hydroxy acid-based ionic liquids and peptides for enhanced anti-aging transdermal delivery.
Lab dish study
Journal of materials chemistry. B · 2025
- Oligomeric hyaluronic acid-modified liposomes effectively improved skin permeability and anti-ageing activity of ellagic acid.
Lab dish study
Scientific reports · 2025
- Developing Plant Exosomes as an Advanced Delivery System for Cosmetic Peptide.
Lab dish study
ACS applied bio materials · 2024
- Topical application of Zanthoxylum piperitum extract improves lateral canthal rhytides by inhibiting muscle contractions.
Lab dish study
Scientific reports · 2020
- The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies.
International journal of cosmetic science · 2026
- Cosmetic potential of Ganoderma lucidum (Reishi) extract in a topical cream formulation.
International journal of cosmetic science · 2026
- Fluorous oligoarginines as supra-enhancers for intracellular and transdermal peptide delivery.
Bioactive materials · 2026
- BAK and ARG Have Moisturizing, Anti-Inflammatory, Antioxidant, and Antioxidant Bioactivities, in the Zebrafish Model.
Journal of cosmetic dermatology · 2025
- Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics.
International journal of toxicology · 2025
- Acetyl Hexapeptide-8 as a Topical Alternative to Botulinum Toxin: A Review of the Literature.
Journal of drugs in dermatology : JDD · 2025
- Single-Molecule Resolution of Oligopeptides in Anti-Aging Cosmetics Combined with Nanopore Readouts and Deep Learning Model
Journal not recorded · 2025
- Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis.
JMIR dermatology · 2024
- INDIVIDUAL ARTICLE: Real-World Clinical Experience With a Neuro-Peptide Serum in Combination With Botulinum Toxin Type-A Injections.
Journal of drugs in dermatology : JDD · 2024
- <i>Mycobacterium abscessus</i> infection after facial injection of argireline: A case report.
World journal of clinical cases · 2021
- Skin scars and wrinkles temporary camouflage in dermatology and oncoesthetics: focus on acetyl hexapeptide-8
La Clinica terapeutica · 2020
- Acetyl Hexapeptide-8 in Cosmeceuticals-A Review of Skin Permeability and Efficacy.
Review of earlier work
International journal of molecular sciences · 2025
- Influence of the modification of the cosmetic peptide Argireline on the affinity toward copper(II) ions.
Review of earlier work
Journal of peptide science : an official publication of the European Peptide Society · 2024
- Cosmeceuticals in photoaging: A review.
Review of earlier work
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
- Polydioxanone Bioactive Sutures-Acetyl Hexapeptide-8 (Argireline): An Intelligent System for Controlled Release in Facial Harmonization.
Review of earlier work
Journal of cutaneous and aesthetic surgery · 2023