ARA-290

4 mg

under the skin · daily · for 12 weeks

The Use of ARA290 for the Treatment of Diabetic Macular OedemaPHASE2 · NCT06626971

“4 mg subcutaneous injections of ARA290 over an 84 day period.”

See source wording

under the skin

Study of Efficacy of ARA 290 on Corneal Nerve Fiber Density and Neuropathic Symptoms of Subjects With SarcoidosisPHASE2 · NCT02039687

“1 mg per day ARA 290.”

4 mg

under the skin · once daily · for 28 days

ARA290 in T2D (Effects of ARA 290, an Erythropoietin Analogue) in Prediabetes and Type 2 Diabetes)PHASE2 · NCT01933529

“ARA 290, 4.0 mg, injected subcutaneously once every morning during 28 days..”

60 mcg/kg

rats · another route

[Intervention effects of erythropoietin derived peptide (HBSP) on renal injury induced by acute skeletal muscle strain in rats].Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology · 2022

“After successful modeling, the rats in HBSP group and EPO group were intraperitoneally injected with 60 μg/kg HBSP and 5 000 U/kg recombinant human erythropoietin (rhEPO), and the rats in the control group and the injured group were intraperitoneally injected with 0.9% normal saline.”

1.7 mcg/kg/day

rats ·

The erythropoietin-derived peptide ARA 284 reduces tissue wasting and improves survival in a rat model of cancer cachexia.Journal of cachexia, sarcopenia and muscle · 2022

“Results Treatment with ARA 284 (1.7 μg/kg/day) counteracted the loss of body weight (12.46 ± 4.82% ARA 284 vs.”

See source wording

mice ·

Transcriptional Profiles in Ischemia/Reperfusion-Injured Murine Kidneys Synergistically Protected by Erythropoietin Derived Peptide CHBP and Caspase-3 siRNAJournal not recorded · 2020

“0.03 mg/kg of CASP3siRNA/negative control (NCsiRNA) was injected via tail vein 2 h pre-surgery, with/without 24 nmol/kg of CHBP administered to peritoneal cavity at 15 min post reperfusion.”

See source wording

rats ·

ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response.Molecular pain · 2014

“Results Following a spared nerve injury in rats, vehicle or ARA290 (administered in either one of 4 doses: 3, 10, 30 and 60 μg/kg) was administered on days 1, 3, 6, 8 and 10.”

120 mcg/kg

rats · another route · daily

The erythropoietin-derived peptide ARA290 reverses mechanical allodynia in the neuritis model.Neuroscience · 2013

“Following neuritis induction, 30 or 120 μg/kg ARA290 or saline vehicle was injected intraperitoneally into rats daily from day 1 post surgery.”

120 mcg/kg

mice · another route

A Nonhematopoietic Erythropoietin Analogue, ARA 290, Inhibits Macrophage Activation and Prevents Damage to Transplanted Islets.Transplantation · 2016

“Recipients were given ARA 290 (120 μg/kg) intraperitoneally just before and at 0, 6, and 24 hours after PITx.”